There are several airlines that operate frequent flights from Panama (PTY) to Detroit (DTW) including

• COPA Airlines with 79 flights a week
• United Airlines with 24 flights a week
• Aeromexico with 21 flights a week
• American Airlines with 8 flights a week
• Delta Air Lines with 6 flights a week

The earliest flight leaves Tocumen Intl. Airport at 01:59 and arrives at Detroit Metropolitan Wayne County Airport at 00:06. The last flight of the day departs Panama at 23:50 and arrives at Detroit at 23:23.

The flight distance from Panama to Detroit is about 4063 km, the shortest flight is 06 hours 59 minutes with United Airlines.

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