There are several airlines that operate frequent flights from Sao Paulo (GRU) to Cleveland (CLE) including

• American Airlines with 39 flights a week
• LATAM Airlines Brasil with 33 flights a week
• United Airlines with 27 flights a week
• Delta Air Lines with 15 flights a week
• Avianca Brasil with 6 flights a week

The earliest flight leaves Guarulhos Governor Andre Franco Montoro Intl. Airport at 00:30 and arrives at Hopkins Intl. Airport at 00:41. The last flight of the day departs Sao Paulo at 23:55 and arrives at Cleveland at 14:14.

The flight distance from Sao Paulo to Cleveland is about 8632 km, the shortest flight is 12 hours 59 minutes with United Airlines."

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