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Hotels in Medical Center District

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Tonight
May 14 - May 15
Tomorrow
May 15 - May 16
This weekend
May 17 - May 19
Next weekend
May 24 - May 26

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Top 10 Hotels in Medical Center District

Exterior
Omni La Mansion del Rio
4.0 star property
9.2 out of 10, Wonderful, (2127)
"The Omni La Mansión Hotel at the Riverwalk in San Antonio was a perfect venue for my husband and I to spend our 50th wedding anniversary at! The location was perfect, the staff is incredibly knowledgeable of their jobs and they’re kind and courteous as well. It’s an older hotel which has been well maintained and updates have been made over the years. Our room was pretty, well equipped with amenities and very comfortable. We had a narrow balcony through our French doors which opened to the street...
The price is S$306
per night
31 May - 1 Jun
Omni La Mansion del Rio
Exterior
Drury Plaza Hotel San Antonio Riverwalk
3.0 star property
9.2 out of 10, Wonderful, (2588)
"This was an outstanding experience! Every single staff member was nice, friendly and helpful. Hotel was clean and easy to get around. Used valet a d found them to be quick and friendly as well. Credit to the brand, will stay here again and will look for Drury Hotels when we stay in other cities too! "
The price is S$217
per night
21 May - 22 May
Drury Plaza Hotel San Antonio Riverwalk
Terrace/patio
Canopy by Hilton San Antonio Riverwalk
4.0 star property
9.2 out of 10, Wonderful, (1264)
"We loved it ! "
The price is S$311
per night
20 May - 21 May
Canopy by Hilton San Antonio Riverwalk
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Frette Italian sheets, premium bedding, pillow-top beds, in-room safe
Hotel Gibbs Downtown Riverwalk
3.5 star property
9.0 out of 10, Wonderful, (2818)
"Really fun historic hotel. Well kept up and maintained. Very friendly staff"
The price is S$183
per night
21 May - 22 May
Hotel Gibbs Downtown Riverwalk
Outdoor pool, a heated pool, open 8:00 AM to 10:00 PM, free pool cabanas
Hotel Contessa
4.0 star property
8.8 out of 10, Excellent, (2729)
"Beautiful area, well cared for on the riverwalk. Saturday was very busy! We loved walking the riverwalk and seeing all the flowers and vegetation! Hotel was very nice and all employees very kind!"
The price is S$299
per night
27 May - 28 May
Hotel Contessa
Miscellaneous
Grand Hyatt San Antonio River Walk
4.0 star property
8.8 out of 10, Excellent, (1062)
"Everything within walking distance "
The price is S$305
per night
27 May - 28 May
Grand Hyatt San Antonio River Walk
Private pool
La Cantera Resort & Spa
4.0 star property
8.8 out of 10, Excellent, (1089)
"Time after time, La Cantera delivers consistent service, good food, and spectacular views. We love our time here. We will be back again soon!"
The price is S$662
per night
26 May - 27 May
La Cantera Resort & Spa
Exterior
Hilton Palacio Del Rio
4.0 star property
8.8 out of 10, Excellent, (1544)
"Great place to stay!"
The price is S$284
per night
26 May - 27 May
Hilton Palacio Del Rio
3 outdoor pools, pool cabanas (surcharge), pool loungers
Hyatt Regency Hill Country Resort & Spa
4.0 star property
8.8 out of 10, Excellent, (1001)
"Great service; hotel is pretty; but a little inconvenience about repairing "
The price is S$514
per night
19 May - 20 May
Hyatt Regency Hill Country Resort & Spa
4 outdoor pools, pool cabanas (surcharge), pool umbrellas
JW Marriott San Antonio Hill Country Resort & Spa
4.5 star property
8.8 out of 10, Excellent, (1001)
"The resort is beautiful and the staff is very friendly. We had the best time with so much to do at the resort."
The price is S$706
per night
27 May - 28 May
JW Marriott San Antonio Hill Country Resort & Spa
Exterior
San Antonio Marriott Rivercenter on the River Walk
4.0 star property
8.8 out of 10, Excellent, (1001)
"Was nice that everything is a short walking distance to all the attractions "
The price is S$300
per night
31 May - 1 Jun
San Antonio Marriott Rivercenter on the River Walk
Breakfast, lunch, dinner served; Italian cuisine
The Westin Riverwalk, San Antonio
4.0 star property
8.6 out of 10, Excellent, (1038)
"Nice"
The price is S$296
per night
29 May - 30 May
The Westin Riverwalk, San Antonio
Exterior
La Quinta Inn & Suites by Wyndham San Antonio Downtown
2.5 star property
8.6 out of 10, Excellent, (2306)
"ON A VERY NICE AREA, FELT REALLY SAFE. SECURITY ON SITE AND CLOSE TO DOWNTOWN AND ALAMODOME. "
The price is S$159
per night
19 May - 20 May
La Quinta Inn & Suites by Wyndham San Antonio Downtown
Front of property
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 star property
8.6 out of 10, Excellent, (2994)
"Everything was good, I don’t have any complaint "
The price is S$152
per night
15 May - 16 May
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Front of property – evening/night
Courtyard Marriott Riverwalk
3.0 star property
8.6 out of 10, Excellent, (1000)
"I had a great stay from, checking in early to breakfast and the valet. Evryone was great. "
The price is S$207
per night
26 May - 27 May
Courtyard Marriott Riverwalk
Outdoor pool, pool umbrellas, pool loungers
Marriott San Antonio Riverwalk
4.0 star property
8.6 out of 10, Excellent, (1001)
"The location was wonderful "
The price is S$379
per night
26 May - 27 May
Marriott San Antonio Riverwalk
Restaurant
Element San Antonio Riverwalk
4.0 star property
8.6 out of 10, Excellent, (237)
"Simple design and very clean!"
The price is S$182
per night
20 May - 21 May
Element San Antonio Riverwalk
Pool
Sonesta ES Suites San Antonio Downtown Alamo Plaza
3.0 star property
8.4 out of 10, Very good, (1315)
"The property is a bit dated but good value for money overall. There is no daily cleaning service so you need to book this in advance. The staff are very friendly and helpful and the daily parking rate is pretty standard for downtown San Antonio"
The price is S$166
per night
2 Jun - 3 Jun
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Exterior
Homewood Suites by Hilton San Antonio Riverwalk/Downtown
3.0 star property
8.4 out of 10, Very good, (1000)
"There was a mold smell when we got there. I asked Destiny, the lady at the front desk, to send maintenance and check the filter. Turns out it hadn’t been changed in years!! That was A bit disconcerting, but they took care of it and after a couple hours, the smell went away. Destiny was wonderful. We really enjoyed our stay mainly because of her."
The price is S$198
per night
27 May - 28 May
Homewood Suites by Hilton San Antonio Riverwalk/Downtown
Meeting facility
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
3.0 star property
8.4 out of 10, Very good, (1481)
"Everyone at the front desk was helpful and provided great customer service. "
The price is S$200
per night
26 May - 27 May
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
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Other neighbourhoods around Medical Center District

Destinations near San Antonio Learn more about Medical Center District
Downtown - Riverwalk showing a river or creek, a bridge and boating

Downtown San Antonio

3 out of top 10 points of interest in this area
4.5/5(42 area reviews)

A scenic riverfront great entertainment and top sights from Alamo to Alamodome – discover Downtown San Antonio, a destination also famous for its historic sites.

Find hotels in Downtown San Antonio

Medical Center District hotels information

Number of reviews
30,552
Accommodation
4,136 hotels
Lowest Price
S$152
Highest Price
S$706

Frequently asked questions

What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighbourhood.

How many hotels will I be able to find in Medical Center District?

Expedia has 127 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and The San Antonio Art Institute. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.

Recent Reviews in Medical Center District

Omni La Mansion del Rio

Omni La Mansion del Rio

5/5 Excellent
"The Omni La Mansión Hotel at the Riverwalk in San Antonio was a perfect venue for my husband and I to spend our 50th wedding anniversary at! The location was perfect, the staff is incredibly knowledgeable of their jobs and they’re kind and courteous as well. It’s an older hotel which has been well maintained and updates have been made over the years. Our room was pretty, well equipped with amenities and very comfortable. We had a narrow balcony through our French doors which opened to the street (it was a nice area to have my morning, coffee and pastry). We thoroughly enjoyed our stay at the Omni at the Riverwalk in San Antonio Texas. When we come back for another visit, we’re about four hours away, will definitely choose to stay with your hotel again thank you so much. And, kudos to all of your Omni staff."
A verified traveller stayed at Omni La Mansion del Rio
Posted 16 hours ago
Omni La Mansion del Rio