The Gatun Locks are one of the most important and historic parts of the Panama Canal, located on the Caribbean side near Colón. Opened in 1914, this original lock system uses three consecutive chambers to raise ships approximately 26 metres (85 feet) above sea level to Gatun Lake, allowing vessels to cross the Isthmus of Panama between the Atlantic and Pacific Oceans. Unlike the newer Agua Clara Locks, Gatun operates with the original lock system, using gravity to move water in and out of the chambers. At the Gatun Locks Visitor Centre, visitors can observe ships passing through the locks at close range and learn about the remarkable engineering, history, and international trade that have made the Panama Canal one of the world's most important waterways.

The Amador Causeway is one of the most beautiful waterfront destinations in Panama City, connecting the mainland to four small islands at the Pacific entrance of the Panama Canal. Built using rocks excavated during the construction of the canal, this scenic road offers spectacular views of the Panama City skyline, the Pacific Ocean, and ships waiting to enter the canal. It is a popular place for walking, cycling, taking photographs, enjoying the ocean breeze, and discovering Panama’s coastal atmosphere. The Causeway is also an excellent place to stop for lunch or dinner, with several restaurants offering fresh seafood, Panamanian cuisine, international dishes, and waterfront dining. Visitors can relax at a restaurant overlooking the ocean, enjoy a meal with views of the city skyline, or have a refreshing drink while watching the sunset over the Pacific.

The Biomuseo area is one of the most distinctive places to visit in Panama City, located at the entrance to the Amador Causeway, near the Pacific entrance of the Panama Canal. Designed by the world-renowned architect Frank Gehry, the colourful Biomuseo celebrates Panama’s natural history and its important role in connecting North and South America, allowing species to migrate between the continents. The surrounding area offers beautiful waterfront scenery, walking paths, and spectacular panoramic views of Panama City’s modern skyline, with its impressive skyscrapers rising along the Pacific coast. From this location, visitors can enjoy excellent photo opportunities featuring the city, the ocean, and ships navigating near the canal entrance. It is an ideal stop for sightseeing, photography, and appreciating the contrast between Panama’s modern architecture, tropical landscape, and maritime heritage.

The Panama Canal Administration Building, located in Balboa, Panama City, is the historic headquarters of the Panama Canal Authority. Inaugurated in 1914, it features elegant architecture and impressive murals depicting the construction of the canal. Today, it symbolises Panama’s engineering achievements, sovereignty, and the global importance of the Panama Canal.

Casco Antiguo, also known as the Old Town of Panama City, is a UNESCO World Heritage Site founded in 1673 after the original Panama City was destroyed by pirates. Its charming streets feature colourful colonial buildings, historic churches, beautiful plazas, and elegant balconies that reflect Spanish, French, and neoclassical architectural influences. Visitors can enjoy panoramic views of the modern city skyline, explore local shops, taste traditional Panamanian cuisine, and discover the history and culture that make this historic district one of Panama’s most fascinating destinations.