Defiance Holidays

  • Plan, book, travel with confidence

  • Better together

    Save up to S$1,300 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Top hotels in Defiance

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
The price is S$132 per night from 17 May to 18 May
S$132
17 May - 18 May
includes taxes & fees
8/10 Very Good! (1,256 reviews)
Bring your pet! Pet friendly, great breakfast, great customer service!!!!

Reviewed on 4 May, 2026

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
The price is S$164 per night from 1 Jun to 2 Jun
S$164
1 Jun - 2 Jun
includes taxes & fees
8.4/10 Very Good! (2,197 reviews)
The soap, shampoo and conditioner dispenser did not work. TV reception was terrible. Tub was very slippery and no handles in shower/tub to help with balance since it was so slippery.

Reviewed on 4 May, 2026

Hollywood Casino & Hotel St. Louis
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
The price is S$259 per night from 25 May to 26 May
S$259
25 May - 26 May
includes taxes & fees
8.6/10 Excellent! (1,005 reviews)
Nice hotel. Very clean and com

Reviewed on 5 May, 2026

Ameristar Casino Resort and Spa
See all 870 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Forest Park

Forest Park

Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.

Forest Park

Chaifetz Arena

Catch an event at Chaifetz Arena during your trip to St. Louis. Amble around the area's picturesque gardens or attend a baseball game.

Chaifetz Arena

What to do in Defiance

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

S$31
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
Downtown St. Louis Smartphone Guided Audio Walking Tour App

Downtown St. Louis Smartphone Guided Audio Walking Tour App

S$10
per adult
100% of travellers recommend
Downtown St. Louis Smartphone Guided Audio Walking Tour App
Best of St. Louis Small Group Tour w/ Arch & River Cruise

St. Louis Premium Small Group Tour With Arch & River Cruise

S$215
per adult
84% of travellers recommend
St. Louis Premium Small Group Tour With Arch & River Cruise
See all activities in Defiance

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.