A street with colorful buildings, palm trees, and parked cars.

Find Luxury Hotels in São Tomé

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on São Tomé Luxury Hotels

This weekend
10 Jul - 12 Jul
Next weekend
17 Jul - 19 Jul

Our top choices for São Tomé luxury hotels

Outdoor pool

Omali São Tomé – Principe Collection

Omali São Tomé – Principe Collection
4.0 star property
São Tomé
9.4 out of 10, Exceptional, (64 reviews)
The price is S$325
includes taxes & fees
16 Jul - 17 Jul
Omali São Tomé – Principe Collection
Pool

Pestana São Tomé

Pestana São Tomé
5.0 star property
Vila Maria
8.2 out of 10, Very good, (83 reviews)
The price is S$363
includes taxes & fees
9 Jul - 10 Jul
Pestana São Tomé
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top São Tomé Hotel Reviews

Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to São Tomé?
São Tomé has some interesting things to see and do including Estadio Nacional 12 de Julho and São Sebastião Museum, so you might want to take in the local sights during your visit.
What's the best luxury accommodation option in São Tomé?
Pestana São Tomé is a luxury hotel with an ocean-view restaurant and private balconies, and it's a popular choice for Expedia travellers looking for an elegant place to stay.
What's there to see and do in São Tomé?
Enjoy São Tomé with a stop at Estadio Nacional 12 de Julho, São Sebastião Museum and Palácio dos Congressos. If you have a little extra time during your trip, you might want to make a stop at Pico São Tomé and Coffee Museum.