Top 10 Downtown Hotels of 2026

A large lake surrounded by dense forests.

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Our top choices for Downtown hotels

A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

1. Best Western Seneca-Clemson

1.7 km from Downtown

Michelle

includes taxes & fees

29 Aug - 30 Aug

A poolside area with outdoor seating and a view of a lake and forested hills.

2. Fairfield Inn & Suites Seneca Clemson Univ Area

2 km from Downtown

Ronald

includes taxes & fees

6 Sept - 7 Sept

A hotel dining area with a long table, multiple chairs, and a bar in the background.

3. Hampton Inn & Suites Seneca-Clemson Area

2.2 km from Downtown

Georgina

includes taxes & fees

6 Sept - 7 Sept

A restaurant interior with a counter, seating area, and a TV mounted on the wall.

4. Quality Inn Seneca US-123

3.8 km from Downtown

Anthony

includes taxes & fees

3 Sept - 4 Sept

A modern dining area with a high ceiling, large windows, and a buffet setup.

5. Days Inn by Wyndham Seneca / Clemson Area

3.1 km from Downtown

John

includes taxes & fees

29 Aug - 30 Aug

A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.

6. Lakeside Lodge Clemson

8.6 km from Downtown

Laura

includes taxes & fees

30 Aug - 31 Aug

An outdoor patio area with a fire pit, seating, and string lights.

7. Tru by Hilton Seneca Clemson

8.4 km from Downtown

Susana

includes taxes & fees

6 Sept - 7 Sept

A reception area with a reception desk, a sofa, a staircase, and a wall with artwork.

8. Inn @ Clemson

11.6 km from Downtown

Terry

includes taxes & fees

28 Aug - 29 Aug

A cabin with a large window, surrounded by trees.

9. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

7.5 km from Downtown

Nirumol

includes taxes & fees

3 Sept - 4 Sept

A golf course with a water body, trees, and a distant view of a bridge.

10. Clemson University's James F. Martin Inn

10.3 km from Downtown

Bill

includes taxes & fees

6 Sept - 7 Sept

A spacious indoor dining area with multiple tables and chairs, a food service counter, and a modern architectural design with balconies.

11. Best Western Plus Clemson Hotel & Conference Center

11.8 km from Downtown

Julio

includes taxes & fees

30 Aug - 31 Aug

A modern kitchen with a microwave, coffee maker, and bar stools.

12. Comfort Inn & Suites Clemson - University Area

11.7 km from Downtown

Anita

includes taxes & fees

20 Sept - 21 Sept

A modern kitchen area with a bar counter and seating.

13. Hampton Inn Clemson-University Area

9.8 km from Downtown

DOUGLAS

includes taxes & fees

6 Sept - 7 Sept

A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.

14. The Abernathy of Clemson

10.1 km from Downtown

Robert

includes taxes & fees

7 Sept - 8 Sept

A modern bar area with a menu board, bar stools, and a countertop with various items.

15. Courtyard Marriott Clemson

12.9 km from Downtown

Gargi

includes taxes & fees

3 Sept - 4 Sept

16. Holiday Inn Express & Suites Clemson by IHG

12.4 km from Downtown

Angela

includes taxes & fees

6 Sept - 7 Sept

A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.

17. The Inn at Patrick Square

15.2 km from Downtown

Beatriz

includes taxes & fees

30 Aug - 31 Aug

A dining area with a table and chairs, large windows with a view of the outside, and a green sofa.

18. Days Inn by Wyndham Clemson

12.5 km from Downtown

David

includes taxes & fees

30 Aug - 31 Aug

A kitchen with a coffee maker, microwave, and refrigerator.

19. Rodeway Inn & Suites Walhalla

12.8 km from Downtown

michael

includes taxes & fees

25 Sept - 26 Sept

A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.

20. The Shepherd Hotel Downtown Clemson

10.6 km from Downtown

Laurrie

includes taxes & fees

8 Sept - 9 Sept

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Where to stay in Downtown

Find the best Downtown areas for the activities you enjoy most.

A sunset over a lake surrounded by dense forests and residential areas.

Serenity Bay

When in Serenity Bay, you can plan a visit to Keowee Key Golf Course and Lake Keowee, some noteworthy sights in the nearby area.

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A sunset over a calm lake with a kayaker and a large tree on the shore.

Pine Ridge Point

If you're looking for some top things to see and do in Pine Ridge Point and surrounding area, you can visit South Beach and Lake Keowee.

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Indian Oaks

While Indian Oaks may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Oconee County Library Seneca Branch and Keowee Reservoir.

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Keowee Plantation

While Keowee Plantation isn't home to many top sights, Oconee County Library Seneca Branch and Keowee Reservoir are some notable places to visit nearby.

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Top Downtown Hotel Reviews

Inn @ Clemson

10/10 Excellent

"It’s"

Best Western Plus Clemson Hotel & Conference Center

8/10 Good

"The front desk woman was super sweet and welcoming. The hotel itself has a lot of character and is pretty cool, although it could definitely use some updating. Our room had a musty smell, and the bathroom floors—especially in the corners—could use a deeper cleaning. Overall, we just needed an affordable place to sleep for one night while visiting Clemson for a tour, and for around $100, it did the job. Not fancy, but perfectly fine for a quick overnight stay."

Microtel Inn & Suites by Wyndham Anderson/Clemson

10/10 Excellent

"I loved being near the freeway, but not hearing the fwy noise. The Continental breakfast had good selections and the staff were prompt to refill items and keep the area very clean. I also loved that they had an alcove nearby with food, drinks, toiletries and OTC s available 24/7for purchase. The only negative was in the room itself: there isn't a closet space with hangers to hang your clothes."

Frequently asked questions

What is Downtown like?

Travellers to the Downtown neighbourhood in Seneca will be sure to enjoy their stay. Make sure that you visit Oconee County Library Seneca Branch and Blue Ridge Arts Center as part of your Downtown travel plans.

How many hotels will I be able to find in Downtown?

If you're searching for places to stay in Seneca, choose from one of Expedia's 12 hotels and other accommodation options in Downtown.

If I need to cancel my hotel reservation in Downtown, will I receive a refund?

Yes! You'll find that most room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your check-in date. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to review the best deals in Downtown.

What can I see and do in this Seneca neighbourhood?

Oconee County Library Seneca Branch, Blue Ridge Arts Center and Seneca Historic District are just a few attractions to check out in Downtown. As you're discovering the neighbourhood, Bertha Lee Strickland Cultural Museum and The Gauntlet are some other places worth a visit. Seneca City Hall, Golden Corner Plaza and Oconee Community Theatre are just a few of the places to visit in and around Downtown. While you're out sightseeing in Seneca, make sure that you visit other sights such as Applewood Shopping Center or Wyndham Plaza.

Hotels in Downtown

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Our top choices for Downtown hotels

1. Best Western Seneca-Clemson

2. Fairfield Inn & Suites Seneca Clemson Univ Area

3. Hampton Inn & Suites Seneca-Clemson Area

4. Quality Inn Seneca US-123

5. Days Inn by Wyndham Seneca / Clemson Area

6. Lakeside Lodge Clemson

7. Tru by Hilton Seneca Clemson

8. Inn @ Clemson

9. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10. Clemson University's James F. Martin Inn

11. Best Western Plus Clemson Hotel & Conference Center

12. Comfort Inn & Suites Clemson - University Area

13. Hampton Inn Clemson-University Area

14. The Abernathy of Clemson

15. Courtyard Marriott Clemson

16. Holiday Inn Express & Suites Clemson by IHG

17. The Inn at Patrick Square

18. Days Inn by Wyndham Clemson

19. Rodeway Inn & Suites Walhalla

20. The Shepherd Hotel Downtown Clemson

Where to stay in Downtown

Serenity Bay

Pine Ridge Point

Indian Oaks

Keowee Plantation

Top Downtown Hotel Reviews

Inn @ Clemson

Frequently asked questions