Lake Nona Medical City Holidays

  • Plan, book, travel with confidence

  • Better together

    Save up to S$134 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas and neighborhoods for the activities you enjoy most. Learn more about Lake Nona Medical City
International Drive showing landscape views

International Drive District

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

Find hotels in International Drive District

Top hotels in Lake Nona Medical City

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

4 out of 5
8800 Vistana Centre Dr Orlando FL
The price is S$188 per night from 1 Mar to 2 Mar
S$188
1 Mar - 2 Mar
includes taxes & fees
9.2/10 Wonderful! (4,529 reviews)
Awesome

Reviewed on 7 Feb, 2026

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
Hyatt Regency Orlando International Airport

Hyatt Regency Orlando International Airport

4 out of 5
9300 Jeff Fuqua Boulevard Orlando FL
Fully refundableReserve now, pay when you stay
The price is S$363 per night from 3 Mar to 4 Mar
S$363
3 Mar - 4 Mar
includes taxes & fees
9.4/10 Exceptional! (3,971 reviews)
Everything was great Mattress aaa comfortable to lie on my only complaint is the pillows are not . If there is anyway you could upgrade to them that would be amazing. Maybe offer different types so the customer can choose the one that is the best for their sleep. Just a suggestion. Look forward to ...

Reviewed on 4 Feb, 2026

Hyatt Regency Orlando International Airport
Universal's Cabana Bay Beach Resort

Universal's Cabana Bay Beach Resort

3.5 out of 5
6550 Adventure Way Orlando FL
The price is S$190 per night from 10 Feb to 11 Feb
S$190
10 Feb - 11 Feb
includes taxes & fees
8.8/10 Excellent! (6,279 reviews)
Hotel was great, staff were lovely can’t wait to come back :)

Reviewed on 6 Feb, 2026

Universal's Cabana Bay Beach Resort
See all 27,511 properties in Lake Nona Medical City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Lake Nona Medical City holiday package cost?
The cheapest Lake Nona Medical City package is , so your dream trip can become a reality — without burning a hole in your pocket. Combine flights, hotels and car rentals to tailor make a package that suits your travel style.
How do I get a cheap travel package to Lake Nona Medical City?
Find flights that fit your busy schedule, add a hotel to your booking and watch the savings rack up with a Lake Nona Medical City holiday package. It's as easy as that! From flights and hotels to tours and rental cars, Expedia makes travelling cheap and easy. And with more than 550 air carriers and 1,000,000 hotel options globally to pick from, you won't be short of choice.
Where should I stay in Lake Nona Medical City?
With loads to explore in Lake Nona Medical City, it'd be convenient for you to stay close to its attractions. Nemours Childrens Hospital, VA Medical Centre at Lake Nona and University of Central Florida College of Medicine are some fascinating ones to add to your to-do list.
What are the top hotels in Lake Nona Medical City?
Make a reservation at Residence Inn Orlando Lake Nona. It's one of the area's most sought-after properties. Another reputable option in Lake Nona Medical City is Courtyard Orlando Lake Nona.
How far in advance should I book my Lake Nona Medical City holiday?
It depends on the airline, but you can generally look up international fares on Expedia up to a year in advance. While it's generally a good idea to book ahead of time, lucky customers occasionally score a cheaper ticket just weeks prior to the date of departure.
What does an Expedia Lake Nona Medical City travel package include?
Expedia has everything you need to organise your Lake Nona Medical City getaway, but what goes into your package is totally up to you. Choose from a combination of hotels, rental cars and flights. In search of some experiences or tours to keep you busy? Once you've made your booking, you can add them too. Whatever your budget or style, there's a deal to match your needs.
What should I know before booking a Lake Nona Medical City travel package?
Locking in all the parts of your escape together is a great way to save. Combine your airfares, rental cars and hotels into one package. But hotels aren't your only option. Expedia has all types of properties, including holiday rentals like beachside villas and city apartments. The list goes on!
Can I choose my airline with a Lake Nona Medical City Expedia holiday package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines worldwide. Our holiday packages give you the freedom to take your pick of available flight, hotel or activity options that fit your needs.
If I'm not able to travel, can I cancel my Lake Nona Medical City holiday package?
Don't worry if you're rethinking your Lake Nona Medical City holiday package — you can cancel or amend your booking. And if you've booked it within 24 hours, you may be able to do it at no cost. However, bookings made more than 24 hours ago may incur a fee from your airline, hotel or car rental company. We know life can throw the occasional spanner in the works, so look up our Customer Service Portal if that occurs. When you're ready to make changes, we'll be here to help.

Popular places to visit

VA Medical Center at Lake Nona

If VA Medical Center at Lake Nona is what brings you to town, hopefully you'll have a chance to explore more of Orlando.

VA Medical Center at Lake Nona

University of Central Florida College of Medicine

Enjoy the student vibe at University of Central Florida College of Medicine during your stay in Orlando. Stroll along the seaside in this family-friendly area or visit its top-notch restaurants.

University of Central Florida College of Medicine

Things to do

Universal Orlando Resort

Universal Orlando Resort Theme Park Tickets

S$182
per adult
78% of travellers recommend
Universal Orlando Resort Theme Park Tickets
Florida: 90 Minute Everglades Cruise

Florida: 90 Minute Everglades Cruise

S$71
per adult
100% of travellers recommend
Florida: 90 Minute Everglades Cruise
Main Court

90 Minute Open Jump at a Trampoline Park in Kissimmee

S$29
per adult
90 Minute Open Jump at a Trampoline Park in Kissimmee
See all activities in Orlando

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.