What is Main Street Fort Pierce like?

Main Street Fort Pierce is a neighbourhood that travellers like for its waterfront, art and shopping. Make sure that you visit Sunrise Theater and Fort Pierce Farmer's Market as part of your Main Street Fort Pierce travel plans.

How many hotels will I find in Main Street Fort Pierce?

Book one of Expedia's 7 hotels and other accommodation options in Main Street Fort Pierce and start exploring everything Fort Pierce has to offer.

If I need to cancel my hotel reservation in Main Street Fort Pierce, will I receive a refund?

Yes! Most room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Add dates, click "Search", then use the "fully refundable" filter to get the best options available in Main Street Fort Pierce.

What is there to do in this Fort Pierce neighbourhood?

Sights like Sunrise Theater and Official Highwaymen Art Gallery can be part of your cultural tour of Main Street Fort Pierce. Fort Pierce Farmer's Market and Fort Pierce City Marina are also a couple of places to visit in the neighbourhood. A few places to visit in the area around Main Street Fort Pierce include Manatee Education and Observation Center, House of Seven Gables and A.E. Backus Museum. Marina at Fort Pierce and Causeway Cove are also worth a visit when you're out sightseeing in Fort Pierce.

Top 10 Main Street Fort Pierce Hotels of 2026

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Our top choices for Main Street Fort Pierce hotels

A hotel lobby with a long dining table, multiple chairs, and a coffee bar with various beverages.

1. Hampton Inn & Suites Ft. Pierce

7.9 km from Main Street Fort Pierce

Angela

includes taxes & fees

15 Nov - 16 Nov

A hotel lobby with a large reception desk, multiple seating areas, and a patterned carpet.

2. Fairfield Inn & Suites by Marriott Fort Pierce

7.7 km from Main Street Fort Pierce

Katherine

includes taxes & fees

8 Nov - 9 Nov

A modern reception area with a long corridor, a reception desk, and a seating area with tables and chairs.

3. Holiday Inn Express Hotel & Suites Fort Pierce West by IHG

8.3 km from Main Street Fort Pierce

Rodney

includes taxes & fees

15 Nov - 16 Nov

An outdoor seating area with fire feature, stone walls, and a view into the building.

4. Home2 Suites by Hilton Ft. Pierce I-95

7.8 km from Main Street Fort Pierce

JERRY

includes taxes & fees

30 Oct - 31 Oct

A pool area with lounge chairs and a hot tub, surrounded by palm trees and a view of the ocean.

5. Hutchinson Island Hotel

3.1 km from Main Street Fort Pierce

Lana

includes taxes & fees

18 Oct - 19 Oct

A spacious living area with a grey sofa, a blue sofa, and a wooden accent wall with a flat-screen TV.

6. La Quinta Inn & Suites by Wyndham Ft. Pierce

7.9 km from Main Street Fort Pierce

riad

includes taxes & fees

15 Nov - 16 Nov

A hotel lobby with a reception desk, seating area, and a hallway leading to other rooms.

7. Days Inn & Suites by Wyndham Fort Pierce I-95

7.8 km from Main Street Fort Pierce

Carlton

includes taxes & fees

15 Nov - 16 Nov

A hotel entrance with a welcome sign, a black mat, and two potted plants.

8. At Home Inn

8.2 km from Main Street Fort Pierce

Ronald

includes taxes & fees

16 Nov - 17 Nov

A clear blue swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a gazebo.

9. Best Western Port St. Lucie

14 km from Main Street Fort Pierce

BRIAN

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a bed, a sofa, and a small table. There are framed pictures on the wall.

10. Comfort Suites Fort Pierce I-95

7.7 km from Main Street Fort Pierce

Marina

includes taxes & fees

8 Nov - 9 Nov

A gym with treadmills, elliptical machines, and a red exercise ball.

11. Hampton Inn & Suites Port St. Lucie, West

17.4 km from Main Street Fort Pierce

Ahim

includes taxes & fees

1 Nov - 2 Nov

A multi-story hotel with a modern design, featuring a prominent sign for 'Springhill Suites Marriott'.

12. SpringHill Suites Port St. Lucie

17.2 km from Main Street Fort Pierce

Amy

includes taxes & fees

23 Oct - 24 Oct

A hotel lobby with a reception desk, a chandelier, a clock, and a sofa.

13. Sleep Inn Fort Pierce I-95

7.9 km from Main Street Fort Pierce

Charity

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a stone fireplace, comfortable seating, and a bar area.

14. Staybridge Suites Vero Beach by IHG

24.1 km from Main Street Fort Pierce

Michelle

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a large bed, a desk, a chair, a television, and a framed picture on the wall.

15. Red Roof Inn Ft Pierce

4.6 km from Main Street Fort Pierce

Rhonise

includes taxes & fees

18 Oct - 19 Oct

A modern cafe with a central island, bar stools, a refrigerated display, and a 'Top It' beverage station.

16. Tru by Hilton Port St. Lucie Tradition

23.7 km from Main Street Fort Pierce

Luz Migdalia

includes taxes & fees

8 Nov - 9 Nov

A restaurant interior with a bar area, wooden flooring, and multiple seating arrangements.

17. Days Inn & Suites by Wyndham Fort Pierce Midtown

4.5 km from Main Street Fort Pierce

Cynthia

includes taxes & fees

18 Oct - 19 Oct

A modern lobby with a fireplace, comfortable seating, and a framed painting above the fireplace.

18. Homewood Suites by Hilton Port Saint Lucie-Tradition

23.1 km from Main Street Fort Pierce

Gordon

includes taxes & fees

31 Oct - 1 Nov

A hotel room with two beds, a television, a ceiling fan, and a view of the beach.

19. The Royal Inn Beach Hotel Hutchinson Island

3.8 km from Main Street Fort Pierce

Taylor

includes taxes & fees

26 Oct - 27 Oct

A hotel room with two beds, a small round table, and artwork depicting a beach scene and a zebra.

20. Redfinn Inn

0.7 km from Main Street Fort Pierce

Robert

includes taxes & fees

19 Oct - 20 Oct

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Where to stay in Main Street Fort Pierce

Find the best Main Street Fort Pierce areas for the activities you enjoy most.

A coastal area with a narrow waterway, a beach, and residential buildings.

Lakewood Park

When in Lakewood Park, you can plan a visit to McKee Botanical Garden and Avalon State Park, some noteworthy sights in the nearby area.

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Spanish Lakes Country Club Village

While Spanish Lakes Country Club Village isn't home to many top sights, Harbor Branch Ocean Discovery Center and McKee Botanical Garden are some notable places to visit nearby.

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A calm lake reflecting trees and a clear sky.

Spanish Lakes Fairways

While there might not be top attractions in Spanish Lakes Fairways, you can explore the larger area and discover places like Lakewood Park Regional Park / Pool and Indrio Road Park / Schoolhouse.

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A coastal city with a bay, mangrove islands, and a clear blue sky.

Meadowood

While Meadowood isn't home to many top sights, Endless Summer Vineyard & Winery and Al's Family Farms are some notable places to visit nearby.

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A mosaic sign with 'Mainstreet Fort Pierce' written on it.

Panther Woods

While Panther Woods may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Endless Summer Vineyard & Winery and Al's Family Farms.

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Top Main Street Fort Pierce Hotel Reviews

Hutchinson Shores Resort & Spa

10/10 Excellent

"The grounds were beautiful and well maintained. Staff was super friendly."

Hampton Inn & Suites Port St. Lucie, West

10/10 Excellent

"Todo excelente la estancia limpieza desayuno cercanos restaurantes etc access rápido al expressway atención al cliente buena house keeping amables piscina limpia and privada todo en general muy bien lo recomiendo y volvere pork me gusto todo incluyendo el area aledaña"

La Quinta Inn & Suites by Wyndham Ft. Pierce

8/10 Good

"Breakfast was good just enough choices to get you going. Coffee was nice and hot! Super friendly at check in and out. Room and bathroom were clean. Beds were a little worn and sank somewhat in the middle but I did get sleep so they aren’t bad. For the price you really can’t beat it!! I would stay there again with my family!"

Hotels in Main Street Fort Pierce

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Be picky

Check prices for these dates

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Our top choices for Main Street Fort Pierce hotels

1. Hampton Inn & Suites Ft. Pierce

2. Fairfield Inn & Suites by Marriott Fort Pierce

3. Holiday Inn Express Hotel & Suites Fort Pierce West by IHG

4. Home2 Suites by Hilton Ft. Pierce I-95

5. Hutchinson Island Hotel

6. La Quinta Inn & Suites by Wyndham Ft. Pierce

7. Days Inn & Suites by Wyndham Fort Pierce I-95

8. At Home Inn

9. Best Western Port St. Lucie

10. Comfort Suites Fort Pierce I-95

11. Hampton Inn & Suites Port St. Lucie, West

12. SpringHill Suites Port St. Lucie

13. Sleep Inn Fort Pierce I-95

14. Staybridge Suites Vero Beach by IHG

15. Red Roof Inn Ft Pierce

16. Tru by Hilton Port St. Lucie Tradition

17. Days Inn & Suites by Wyndham Fort Pierce Midtown

18. Homewood Suites by Hilton Port Saint Lucie-Tradition

19. The Royal Inn Beach Hotel Hutchinson Island

20. Redfinn Inn

Where to stay in Main Street Fort Pierce

Lakewood Park

Spanish Lakes Country Club Village

Spanish Lakes Fairways

Meadowood

Panther Woods

Top Main Street Fort Pierce Hotel Reviews

Hutchinson Shores Resort & Spa

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