Mesopotamia Holidays

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  • Better together

    Save up to S$1,300 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Things to do in Mesopotamia

In Mesopotamia, Argentina, visitors can indulge in birdwatching, hiking, and exploring the diverse wildlife. Essential activities include embarking on a Mesopotamia tour to uncover the region's ancient history, participating in various cultural rituals, and enjoying festive processions that showcase local traditions. These experiences offer a unique insight into the rich cultural tapestry of this captivating area.

Shopping

A short stroll from the city centre, you'll discover the vibrant shopping scene at Shopping Sur, offering a mix of local crafts and international brands. For a more authentic experience, head to the Mercado de Posadas, where you can find unique souvenirs and traditional Argentine products.

Recreation

Experience rejuvenation at serene spas offering thermal baths and holistic treatments. Engage in yoga sessions surrounded by nature, explore lush landscapes, and partake in mindfulness workshops. Indulge in local cuisine while enjoying tranquil river views, creating a harmonious blend of relaxation and cultural immersion in Mesopotamia.

Adventure

Explore the captivating Iguazu Falls, where you can take exhilarating boat rides and hike through lush rainforest trails. Experience the rich biodiversity at the Iberá Wetlands, perfect for kayaking, birdwatching, and spotting wildlife in their natural habitat.

Nightlife

The nightlife in Mesopotamia is vibrant, with lively bars and clubs. Enjoy a cocktail at La Cabaña, renowned for its atmosphere, or dance the night away at Club del Río, where local music creates an unforgettable experience.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions near Mesopotamia

Mesopotamia, Argentina, offers a wealth of attractions, particularly for those seeking scenic outdoor adventures. Explore the stunning national parks while discovering the rich history of numerous Mesopotamian gods and the vibrant festivals of ancient Mesopotamia. Experience the legacy of the ancient Mesopotamians as you immerse yourself in the local culture and natural beauty that surrounds this unique destination.

  • Portal Carambola: Enjoy breathtaking scenery and immerse yourself in outdoor adventures at this national park, located 22.5km from Mesopotamia. Explore its diverse landscapes and engage in thrilling activities amidst nature’s beauty.

Best time to go to Mesopotamia

The best time to visit Mesopotamia depends on your weather preferences. The hottest average temperature around Mesopotamia is in January and February. February is mostly sunny. The coolest average temperature around Mesopotamia is in May and July. July is mostly sunny.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January80.1°F (26.700000000000003°C)Light RainSunnyModerately HighAverage
February77.7°F (25.4°C)Light RainMostly Sunny
March72.9°F (22.700000000000003°C)Light RainMostly SunnyModerately HighAverage
April66.7°F (19.3°C)Light RainMostly SunnyAverageAverage
May59.5°F (15.3°C)Light RainMostly Sunny
June60.1°F (15.6°C)Light RainMostly Sunny
July53.4°F (11.9°C)Light RainMostly SunnyAverageSlightly High
August63.7°F (17.6°C)Light RainMostly SunnyAverageSlightly High
September60.6°F (15.9°C)Light RainMostly SunnyAverageAverage
October65.8°F (18.8°C)Light RainMostly SunnyAverageAverage
November72.3°F (22.4°C)Light RainSunnyModerately HighAverage
December77.0°F (25.0°C)Light RainSunnyAverageSlightly High

Tips to save on your trip to Mesopotamia

  • Combine your flights, hotels and car rentals on Expedia—bundling can result in significant savings.
  • Consider traveling during the off-peak season (typically ) for more affordable package holidays to Mesopotamia.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

Top hotels in Mesopotamia

Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
Fully refundableReserve now, pay when you stay
The price is S$206 per night from 4 Nov to 5 Nov
S$206
4 Nov - 5 Nov
9.8/10 Exceptional! (51 reviews)
"2 cosas, faltaban toallas en el baño y otra que no me atendieron para poder pedir otra reserva"

Reviewed on 18 Oct, 2026

Marriott Corrientes Hotel
Costarenas Hotel & Spa

Costarenas Hotel & Spa

3.5 out of 5
12 de Abril y Quiros Colon Entre Rios
The price is S$156 per night from 29 Oct to 30 Oct
S$156
29 Oct - 30 Oct
8.8/10 Excellent! (65 reviews)
"Estaba todo muy lindo"

Reviewed on 8 Jun, 2026

Costarenas Hotel & Spa
O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
Fully refundableReserve now, pay when you stay
The price is S$59 per night from 29 Oct to 30 Oct
S$59
29 Oct - 30 Oct
O2 Hotel Gualeguaychú
See all 531 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Mesopotamia attractions

A dirt path through a dense palm tree forest.

El Palmar National Park

8.0/10 (2 reviews)
Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay.
See properties

Frequently asked questions

How much does a Mesopotamia holiday package cost?
Maybe less than you might think — from only , actually! By combining hotels, flights and car rentals into your own tailor-made package, your Mesopotamia escape is just a few clicks away.
How do I get a cheap travel package to Mesopotamia?
Crafting your own Mesopotamia holiday package with Expedia is a great way to save. We offer more than 550 partner airlines and 1,000,000 hotels across the globe. With such a broad range to choose from, you'll have no worries creating your next dream adventure.
What are the top hotels in Mesopotamia?
Costarenas Hotel & Spa and Hotel Queguay know how to make their guests feel welcome in Colon. If your itinerary also includes Parana, check out Mayim Hotel Termal & Spa and Costarenas Hotel & Spa. Both are very popular with travellers.
How far in advance should I book my Mesopotamia holiday?
It all depends on the airline, but you can usually compare international fares on Expedia nearly a year in advance. While it's generally a good idea to book ahead of time, lucky travellers occasionally nab a cheaper ticket just weeks before departure dates.
What does an Expedia Mesopotamia travel package include?
You can choose from a combination of hotels, rental cars and flights. Once you've made your booking, you can add the fun stuff like experiences and activities. Want to pick your fare class? That's also easy to do. The choice is all yours when it comes to arranging your perfect Mesopotamia trip.
What should I know before booking a Mesopotamia travel package?
Booking all the parts of your getaway together is a smart way to save. Bundle your flights, car rentals and hotels into a convenient package. But it's not just hotels. Expedia has all types of properties, including holiday rentals such as mountain cabins and serviced residences. The list is almost endless!
Can I choose my airline with a Mesopotamia Expedia holiday package?
Yes, and with over 550 airlines to select from worldwide, you're not short on choice. Search the available options and find out which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Mesopotamia holiday package?
Don't worry if you're rethinking your Mesopotamia holiday package — you can cancel or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We realise life can throw the occasional spanner in the works, so head to our Customer Service Portal if that occurs. When you're ready to make changes, we'll take care of it.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.