A coastal town with a pier, boats, and a hillside with buildings.

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Check availability on Pythagorio Luxury Hotels

Tonight
11 Oct - 12 Oct
Tomorrow
12 Oct - 13 Oct
Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

Our top choices for Pythagorio luxury hotels

A beach with rows of beige lounge chairs and umbrellas, a clear sky, and a calm sea with a distant mountain.
A beachside lounge with white umbrellas and beige lounge chairs, a wooden deck, and a view of the sea and a pier in the background.
A coastal hotel with a swimming pool, surrounded by greenery and overlooking the sea.
A modern kitchen with a central island, pendant lighting, and a tiled backsplash.

1. Doryssa Seaside Resort

Doryssa Seaside Resort
Samos
  • Relish beachfront luxury at this Samos seaside resort where warm staff, 2 outdoor pools, and a private beach create an indulgent escape.
S$298
includes taxes & fees
12 Oct - 13 Oct
Doryssa Seaside Resort
A modern resort with a central pool, lounge areas, and mountain views.
A beachside resort with outdoor seating areas, umbrellas, and a view of the sea.
A bar area with a wooden counter and stools.
A beachside lounge area with outdoor seating, a large umbrella, and a view of the sea.

2. Casa Cook Samos

Casa Cook Samos
Samos
  • Beachfront luxury meets spa indulgence at Casa Cook Samos, where Mediterranean elegance awaits.
S$345
includes taxes & fees
28 Oct - 29 Oct
Casa Cook Samos
A row of wooden beach umbrellas with white cushions on a sandy beach, overlooking the sea.
A serene outdoor setting with a pool, a person in a white dress, and a view of the sea.
A modern bedroom with a bed, bedside tables, a desk, and a view of the sea.
A beach with rows of sunbeds and thatched umbrellas, a clear blue sea, and mountains in the background.

3. Proteas Blu Resort - Adults Only

Proteas Blu Resort - Adults Only
Samos
  • Private beachfront luxury meets seaside serenity at this adults-only Samos resort offering spa indulgences and ocean-view dining.
S$240
includes taxes & fees
12 Oct - 13 Oct
Proteas Blu Resort - Adults Only
An infinity pool with lounge chairs and a view of a coastal town.
A modern interior with a dark wood reception desk, a sofa, a large abstract painting, and a potted plant.
A bar area with stools, a counter, and bottles.
A modern multi-story building with a landscaped courtyard, featuring a mix of flat and sloped roofs, and a variety of plants and trees.

4. Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)

Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)
Samos
S$241
includes taxes & fees
23 Oct - 24 Oct
Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)
A sunlit outdoor seating area with a view of the sea, featuring lounge chairs, a small table, and a decorative fence.
A bedroom with a bed, a nightstand, a lamp, a wooden door, and a wall mural.
A living room with a fireplace, a sofa, a coffee table, and a staircase leading to an upper level.
A dining area with a round wooden table, chairs, a hanging light fixture, and a stone wall.

5. Villa of the old olive oil factory

Villa of the old olive oil factory
Samos
S$227
includes taxes & fees
19 Oct - 20 Oct
Villa of the old olive oil factory
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Top Pythagorio Hotel Reviews

Doryssa Seaside Resort

Doryssa Seaside Resort

10/10 Excellent
"A gorgeous property, great location, courteous staffโ€ฆ would def stay there again!! Perfect room!!๐Ÿ˜Š"
Athanasios 2-night trip
Posted 2 weeks ago
Doryssa Seaside Resort

Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to Pythagorio?
During your visit, you might want to enjoy the port which Pythagorio is known for.
What's the best luxury hotel in Pythagorio?
Casa Cook Samos is a luxury hotel with a beachfront restaurant and 2 bars, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Proteas Blu Resort - Adults Only and Doryssa Seaside Resort are other upscale choices for your trip.
When can I expect good weather in Pythagorio?
Planning for the weather is an important factor for making your trip to Pythagorio a success, especially when you're splurging. The hottest months are usually August and July, with an average temperature of 25ยฐC, while the coldest months are January and February, with an average of 13ยฐC. Average annual precipitation for Pythagorio is 837 mm.
What's there to see and do in Pythagorio?
Experience Pythagorio with a stop at Samos Pythagorion Archaeological Museum, Pythagoreion and Glicorisa Beach. If you have spare time during your trip, you might want to make a stop at Tunnel of Eupalinos and Potakaki beach.