Hotels near Sanford USD Medical Center

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
30 Dec - 31 Dec
Tomorrow
31 Dec - 1 Jan
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Sanford USD Medical Center hotels

Terrace/patio
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
3.0 star property
University Heights, 0.1 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (587)
"This is a great hotel - centrally located and very clean and quiet. Will definitely be staying there again. "
United States
Tracey
The price is S$163
includes taxes & fees
4 Jan - 5 Jan, 2026
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
Interior detail
Hotel On Phillips

Hotel On Phillips

Hotel On Phillips
2.5 star property
Downtown Sioux Falls, 1.8 km from Sanford USD Medical Center
9.6 out of 10, Exceptional, (1309)
"Great staff and location!"
United States
Gerald
Hotel On Phillips
Free daily continental breakfast
Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls
3.0 star property
Mall District, 2.9 km from Sanford USD Medical Center
9.6 out of 10, Exceptional, (1001)
"Absolutely beautiful places to stay with family excellent service staff great food service great hospitality great "
United States
Rosario
Clubhouse Hotel Suites Sioux Falls
Meeting facility
Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown
4.0 star property
Downtown Sioux Falls, 2.4 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (160)
"Room was very clean, great overall stay."
United States
Destiny
The price is S$192
includes taxes & fees
15 Jan - 16 Jan, 2026
Canopy By Hilton Sioux Falls Downtown
Living area
Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown
3.0 star property
Downtown Sioux Falls, 2 km from Sanford USD Medical Center
9.0 out of 10, Wonderful, (890)
"Friendly front desk staff, clean room, great location, safe "
United States
Hannah
The price is S$154
includes taxes & fees
8 Jan - 9 Jan, 2026
Hilton Garden Inn Sioux Falls Downtown
Porch
Historic Victorian Inn

Historic Victorian Inn

Historic Victorian Inn
3.0 star property
Cathedral, 1.4 km from Sanford USD Medical Center
8.8 out of 10, Excellent, (56)
"It was a great place to stay and super interesting."
United States
Kathy
The price is S$241
includes taxes & fees
5 Jan - 6 Jan, 2026
Historic Victorian Inn
Exterior
Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG
3.0 star property
Downtown Sioux Falls, 1.8 km from Sanford USD Medical Center
8.6 out of 10, Excellent, (1000)
"Always a great stay. "
United States
Shawn
The price is S$125
includes taxes & fees
25 Jan - 26 Jan, 2026
Holiday Inn Sioux Falls-City Centre by IHG
Exterior
Country Inn & Suites by Radisson, Sioux Falls

Country Inn & Suites by Radisson, Sioux Falls

Country Inn & Suites by Radisson, Sioux Falls
3.0 star property
Downtown Sioux Falls, 1.9 km from Sanford USD Medical Center
8.4 out of 10, Very good, (1168)
"It was a great place to stay!"
United States
Trinity
The price is S$120
includes taxes & fees
4 Jan - 5 Jan, 2026
Country Inn & Suites by Radisson, Sioux Falls
Lobby
Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center
4.0 star property
Northwest Sioux Falls, 2.8 km from Sanford USD Medical Center
8.6 out of 10, Excellent, (1002)
"Travelling thru with 2 small dogs. Hotel was very accommodating to pet owners... Will stay here again on our way back."
Canada
Shelly
The price is S$139
includes taxes & fees
11 Jan - 12 Jan, 2026
Sheraton Sioux Falls Hotel & Convention Center
Free daily continental breakfast
The Center Inn

The Center Inn

The Center Inn
2.5 star property
All Saints, 2.3 km from Sanford USD Medical Center
8.4 out of 10, Very good, (703)
"Room and staff were great. "
United States
Annette
The Center Inn
Desk, free WiFi, wheelchair access
Valley Inn

Valley Inn

Valley Inn
2.5 star property
University Heights, 0.1 km from Sanford USD Medical Center
7.6 out of 10, Good, (1002)
"Room was clean, staff was friendly, very convenient location "
United States
Theresa
Valley Inn
3 indoor pools, open 9:00 AM to 10:00 PM, pool loungers
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
3.0 star property
Northwest Sioux Falls, 2.9 km from Sanford USD Medical Center
7.8 out of 10, Good, (1467)
"staff was friendly "
United States
Rob
The price is S$93
includes taxes & fees
4 Jan - 5 Jan, 2026
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
Dining room
Historic Twin Tudors Inn

Historic Twin Tudors Inn

Historic Twin Tudors Inn
3.0 star property
1.3 km from Sanford USD Medical Center
8.8 out of 10, Excellent, (3)
"Lovely place! Wish we could have stayed longer. Steve was attentive and helpful. "
United States
Anonymous traveller
The price is S$392
includes taxes & fees
31 Dec - 1 Jan, 2026
Historic Twin Tudors Inn
Pool
Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites
2.0 star property
Northwest Sioux Falls, 2.9 km from Sanford USD Medical Center
7.0 out of 10, Good, (52)
"Very friendly at check in. Great service at bar."
United States
Chris
Ramada by Wyndham Sioux Falls Arpt & Suites
In-room safe, desk, laptop workspace, blackout curtains
Highpoint Hotel

Highpoint Hotel

Highpoint Hotel
3.0 star property
University Heights, 0.3 km from Sanford USD Medical Center
The price is S$217
includes taxes & fees
12 Jan - 13 Jan, 2026
Highpoint Hotel
Lobby
Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls
2.0 star property
2.7 km from Sanford USD Medical Center
5.6 out of 10, (1003)
"Good room for the price."
United States
Michael
The price is S$74
includes taxes & fees
5 Jan - 6 Jan, 2026
Ramada by Wyndham Sioux Falls
Terrace/patio
Hyatt Place Sioux Falls South

Hyatt Place Sioux Falls South

Hyatt Place Sioux Falls South
3.0 star property
Mall District, 3.8 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (1003)
"Great stay!"
United States
Nick
The price is S$167
includes taxes & fees
8 Jan - 9 Jan, 2026
Hyatt Place Sioux Falls South
Front of property – evening/night
Hampton Inn Sioux Falls

Hampton Inn Sioux Falls

Hampton Inn Sioux Falls
2.5 star property
Mall District, 3.2 km from Sanford USD Medical Center
9.2 out of 10, Wonderful, (1001)
"It was a very nice stay. "
United States
Lenore
The price is S$152
includes taxes & fees
5 Jan - 6 Jan, 2026
Hampton Inn Sioux Falls
Exterior
Staybridge Suites Sioux Falls by IHG

Staybridge Suites Sioux Falls by IHG

Staybridge Suites Sioux Falls by IHG
3.0 star property
Mall District, 3.3 km from Sanford USD Medical Center
9.2 out of 10, Wonderful, (1006)
"Room was so nice we decided to stay an extra day and the lady at the front desk was super helpful with that! Would definitely stay here again."
United States
Victoria
The price is S$139
includes taxes & fees
4 Jan - 5 Jan, 2026
Staybridge Suites Sioux Falls by IHG
Exterior
La Quinta Inn & Suites by Wyndham Sioux Falls

La Quinta Inn & Suites by Wyndham Sioux Falls

La Quinta Inn & Suites by Wyndham Sioux Falls
3.0 star property
Mall District, 4.1 km from Sanford USD Medical Center
9.2 out of 10, Wonderful, (1557)
"Great place "
United States
Keegan
The price is S$115
includes taxes & fees
18 Jan - 19 Jan, 2026
La Quinta Inn & Suites by Wyndham Sioux Falls
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Sanford USD Medical Center Hotel Reviews

Hotel On Phillips

Hotel On Phillips

10/10 Excellent
"Clean and spacious room. "
Curtis 1-night trip
Posted 2 days ago
Hotel On Phillips

Hotels near other Sanford USD Medical Center attractions

Sioux Empire Medical Museum

You can spend time studying the exhibits at Sioux Empire Medical Museum during your travels in Sioux Falls. In the area, take in the entertainment choices and beautiful waterfalls.
See properties

University of Sioux Falls

4.1/5 (170 reviews)
Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.
See properties

Frequently asked questions

What's the area like around Sanford USD Medical Center?
Sanford USD Medical Center is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, take a look at the 109 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Sanford USD Medical Center?
Adjacent to Sanford USD Medical Center, Home2 Suites By Hilton Sioux Falls/Sanford Medical Center is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. Another good choice is Valley Inn, located just 0.1 mi (0.1 km) away.
How many hotels should I expect to find close to Sanford USD Medical Center?
Expedia has 109 hotels and other accommodation options within a mile from Sanford USD Medical Center.
If I need to cancel the hotel reservation for my stay near Sanford USD Medical Center, will I receive a refund?
Yes! Most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within 24 hours of your booking. Add dates, click "Search", then you can use the "fully refundable" filter to get the best deals near Sanford USD Medical Center.
What can I see and do near Sanford USD Medical Center?
Study the collections at Washington Pavilion of Arts and Science, Center for Western Studies or Old Courthouse Museum. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. Local parks like Falls Park, Sherman Park and Spencer Dog Park are peaceful spots to stop and take in some fresh air.