Hotels in Santa Ana

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Our top choices for Santa Ana hotels

Casa Buho B&B

Casa Buho B&B
3.0 star property
Santa Ana
9.2 out of 10, Wonderful, (48)
"Great place !!"
United States
Abner Israel Polanco
The price is S$82
includes taxes & fees
17 Jan - 18 Jan, 2026
Casa Buho B&B

Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
8.6 out of 10, Excellent, (12)
"Space was clean and had a cozy vibe."
United States
Evelin
Villas Santa Ana-Ricardo

Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (21)
"Nice clean affordable accomodations and very accomodating and amicable hosts."
United States
Feng
The price is S$73
includes taxes & fees
2 Jan - 3 Jan, 2026
Hostal Casa Buho

Posada el Antaño

Posada el Antaño
3.0 star property
Historic Center, 1.7 km from Santa Ana
8.8 out of 10, Excellent, (71)
"Location"
Mexico
Gloria
The price is S$153
includes taxes & fees
7 Jan - 8 Jan, 2026
Posada el Antaño

Hotel Posada del Angel

Hotel Posada del Angel
4.0 star property
1 km from Santa Ana
9.6 out of 10, Exceptional, (280)
"The breakfast on the rooftop where we could watch the volcano erupt was spectacular. Breakfast was delicious and service was top notch. We stayed in the Rose Suite and loved it."
United States
Amelia
Hotel Posada del Angel

Pensativo House Hotel

Pensativo House Hotel
4.5 star property
1 km from Santa Ana
9.4 out of 10, Exceptional, (389)
"Great Staff! Very Clean and awesome views!"
United States
Bryan
Pensativo House Hotel

Hotel Cacique Real

Hotel Cacique Real
3.0 star property
1.8 km from Santa Ana
9.0 out of 10, Wonderful, (160)
"Great location and nice place "
United States
Susana
The price is S$152
includes taxes & fees
22 Dec - 23 Dec
Hotel Cacique Real

Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.6 out of 10, Excellent, (347)
"Excellent customer service from the staff, great food, room was very clean and a block away from the park."
United States
Rodrigo
Ciel-Luxe Hotels

Las Cruces Boutique Hotel

Las Cruces Boutique Hotel
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.8 out of 10, Exceptional, (222)
"Great place!"
United States
Ragnar
The price is S$394
includes taxes & fees
14 Jan - 15 Jan, 2026
Las Cruces Boutique Hotel

Meson Panza Verde

Meson Panza Verde
3.5 star property
1.1 km from Santa Ana
9.2 out of 10, Wonderful, (435)
"Great location "
United States
Jami
The price is S$239
includes taxes & fees
20 Dec - 21 Dec
Meson Panza Verde

Casa Noble Hotel

Casa Noble Hotel
3.0 star property
0.9 km from Santa Ana
9.6 out of 10, Exceptional, (166)
"Staff very friendly, breakfeast was good"
United States
HUBER
Casa Noble Hotel

Hotel Casa Bansley

Hotel Casa Bansley
2.5 star property
2.3 km from Santa Ana
9.8 out of 10, Exceptional, (46)
"Property is beautiful and staff are great"
United States
Michael
The price is S$201
includes taxes & fees
24 Dec - 25 Dec
Hotel Casa Bansley

Luna Maya Boutique Hotel

Luna Maya Boutique Hotel
3.0 star property
1.5 km from Santa Ana
9.6 out of 10, Exceptional, (22)
"Really nice experience. Room was clean and the staff was very friendly. Will go back again."
United States
Wilfredo
The price is S$115
includes taxes & fees
11 Jan - 12 Jan, 2026
Luna Maya Boutique Hotel

Hotel La Posadita Antigua

Hotel La Posadita Antigua
3.0 star property
1.9 km from Santa Ana
8.8 out of 10, Excellent, (38)
"Location and friendly staff"
United States
Jose Alejandro
Hotel La Posadita Antigua

Indian Palace

Indian Palace
3.0 star property
2.8 km from Santa Ana
9.2 out of 10, Wonderful, (26)
"Beautiful view to the volcanics clean area Beautiful pool, good game room i will recommend."
United States
Estuardo
The price is S$107
includes taxes & fees
21 Dec - 22 Dec
Indian Palace

Hotel Meson de Maria

Hotel Meson de Maria
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.0 out of 10, Wonderful, (188)
"Beautiful property and very friendly staff! The breakfast is also very good!"
United States
Monty
Hotel Meson de Maria

Naif Boutique Hotel

Naif Boutique Hotel
3.0 star property
Historic Center, 1.4 km from Santa Ana
9.0 out of 10, Wonderful, (372)
"Well located, friendly staff. Would stay again."
United States
Cristian Paolo
The price is S$183
includes taxes & fees
23 Dec - 24 Dec
Naif Boutique Hotel

Hotel Posada San Vicente

Hotel Posada San Vicente
2.5 star property
Historic Center, 1.4 km from Santa Ana
8.0 out of 10, Very good, (203)
"Staff is great plus the location "
Canada
RICHARD
The price is S$76
includes taxes & fees
21 Dec - 22 Dec
Hotel Posada San Vicente

San Rafael Hotel

San Rafael Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.8 out of 10, Exceptional, (439)
"Helpful and courteous staff, clean room, excellent location and beautiful common areas. Super quiet and peaceful. "
United States
Ricardo
The price is S$309
includes taxes & fees
20 Dec - 21 Dec
San Rafael Hotel

Why Not Hotel

Why Not Hotel
3.0 star property
Historic Center, 1.5 km from Santa Ana
8.4 out of 10, Very good, (147)
"clean and spacious room "
Italy
Teresa
The price is S$68
includes taxes & fees
6 Jan - 7 Jan, 2026
Why Not Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Historic Center

If you're spending some time in Historic Center, Central Park and Santa Catalina Arch are top sights worth seeing.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Travellers to the Santa Ana neighbourhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favourite place to stay in Santa Ana?
Based on Expedia customer reviews, Casa Buho B&B is the highest ranked property in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 17 hotels and other accommodation options in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view top deals in Santa Ana.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, make sure that you visit other sights such as Tanque La Unión or Museo del Hermano Pedro.