When you travel with your pet, keeping track of the weather can help you make the trip more safe and fun for everyone. The hottest months are usually February and March, with an average temperature of 29°C, while the coldest months are November and October, with an average of 27°C. The rainiest months in Santa Cruz de Mompox are May, October, August and September, with each month seeing an average of 365 mm of rainfall.