Santa Cruz Island Holidays

  • Plan, book, travel with confidence

  • Better together

    Save up to S$134 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

The Annual Holiday Sale

Members save up to 40% on hotels. Plan this year’s big trip and save.
Book now

Top hotels in Santa Cruz Island

Hotel Fiesta

Hotel Fiesta

3.5 out of 5
Calle Moises Brito y Juan Montalvo Puerto Ayora Galapagos
Fully refundableReserve now, pay when you stay
The price is S$198 per night from 8 Apr to 9 Apr
S$198
8 Apr - 9 Apr
9/10 Wonderful! (395 reviews)
Good reception staff. Good breakfast

Reviewed on 20 Feb, 2026

Hotel Fiesta
Maidith Galapagos Inn

Maidith Galapagos Inn

3 out of 5
Calle Cucuve #341 y Seymour, Santa Cruz Puerto Ayora Galápagos
The price is S$184 per night from 26 Mar to 27 Mar
S$184
26 Mar - 27 Mar
10/10 Exceptional! (117 reviews)
The hotel is just like the pictures. It’s close to the Darwin Center and we were able to walk everywhere. The owners could not do enough for us and SO kind and friendly. The breakfast was unbelievable. There was fresh fruit everyday with yogurt and granola, juice, unlimited coffee and something homemade ...

Reviewed on 8 Mar, 2026

Maidith Galapagos Inn
Hotel el descanso del Guia

Hotel el descanso del Guia

3.5 out of 5
Calle Delfin, Barrio el Mirador Puerto Ayora Galapagos
8.8/10 Excellent! (193 reviews)
The staff was amazing, so attentive and kind!

Reviewed on 25 Feb, 2026

Get rates
Hotel el descanso del Guia
See all 213 properties in Santa Cruz Island
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Can I cancel my flight booking to Santa Cruz Island due to COVID-19?
Many airlines now provide more flexibility due to COVID-19. Our convenient Customer Service Portal will help answer most queries about which policies apply to your flight. It's also worth scanning over the terms and conditions of your chosen carrier — preferably before locking in your seat!
What's the best way to find cheap flights to Santa Cruz Island that have flexible change policies?
We know that travel arrangements can change from one day to the next, so choosing a flexible fare with Expedia is always a wise idea. Simply tick the "No change fee" box below the "Flexible change policies" filter. Your low-cost, flexible flight to Santa Cruz Island is only a few clicks away.
What are some of the general tips for travellers to Santa Cruz Island during the COVID-19 outbreak?
The COVID-19 pandemic has brought about big changes to the way we travel. If you're planning an escape to Santa Cruz Island, the following tips will help you navigate this new travelling reality:
  • Research if any travel restrictions apply to your origin and destination before booking your flight. Also check if there are any requirements you'll have to follow on arrival, such as health testing.
  • Wear a face mask even during airport screening. A TSA officer will require you to adjust your mask for identification purposes.
  • You're no longer required to hand your boarding pass (paper or electronic) directly to a TSA officer. Rather, you should position the pass on the reader and then hold it up to allow the agent to visually inspect it.
  • You are now allowed to take one container of hand sanitizer up to 12 oz (350 ml) in your carry-on luggage. This will need to be removed for X-ray scanning.
  • To minimize handling during the screening process, place items such as your phone, wallet and keys into your carry-on instead of the bins.
  • Separate any food you have for screening. Food items often trigger the alarm. Putting them in a clear plastic bag and into a bin reduces the need for a TSA agent to touch and inspect your belongings.

Which airlines fly to Santa Cruz Island?
LATAM Airlines Ecuador runs flights into or near Santa Cruz Island, including 60 that arrive at Seymour Airport (GPS) each month. Choose your holiday dates and then secure your seat early for the best price.
How can I find cheap tickets to Santa Cruz Island?
For the best deal to Santa Cruz Island, book well ahead of time. Also make use of Expedia's "flexible dates" link at the top of your search results. This will display prices for similar time frames. In the last seven days, was the lowest price for a flight to Santa Cruz Island.
How much is a flight to Santa Cruz Island?
If you were flying one way from (), you could've picked up a cheap ticket for in the last seven days. Round-trip flights to Santa Cruz Island ranged from only to during this same period.
What are the most popular airports to fly into in Santa Cruz Island?
Seymour Airport (GPS) is the main entryway for people travelling into and out of Santa Cruz Island. Approximately 95 flights a month touch down at this airport.
When is the cheapest time to fly to Santa Cruz Island?
Departing on a Tuesday, followed by a Monday, is generally the best way to bag the cheapest fare. Avoid the weekends if you can, because Saturday is typically the most expensive day of the week. Spend the cash you saved having a good time in Santa Cruz Island instead!
How much is a plane ticket to Santa Cruz Island?
In the last seven days, plane tickets to Santa Cruz Island fluctuated between and . Prices rise as your travel date nears, so grab a terrific deal today.
Which airlines with flights to Santa Cruz Island employ COVID-19 cleanliness policies?
Like most things, plane travel is looking very different nowadays. Airlines worldwide have adopted a range of measures, including social distancing, to slow the spread of COVID-19. Here are some of them:
  • LATAM Airlines Ecuador - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Avianca - this airline is known for conducting passenger temperature checks and cleaning with disinfectant.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.