Santa Cruz Holidays
- Plan, book, travel with confidence
- Better togetherSave up to S$1,300 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Where to stay in Santa Cruz
Find the best Santa Cruz areas for the activities you enjoy most.
Hamacas
When in Hamacas, you can plan a visit to Santa Cruz Zoo and Las Brisas Shopping Center, some noteworthy sights in the nearby area.
Top hotels in Santa Cruz
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Ave. San Martin, #455 Santa Cruz
S$162
23 Aug - 24 Aug
9/10 Wonderful! (401 reviews)
"Great breakfast and beautiful property. Would come here again. Felt safe and comfortable."
Reviewed on 16 Aug, 2026
Ibis Santa Cruz DE LA Sierra
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
S$44
31 Aug - 1 Sept
9.4/10 Exceptional! (132 reviews)
"Excelente espacio Muy amable el personal"
Reviewed on 12 Aug, 2026
Marriott Santa Cruz de la Sierra Hotel
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
S$135
22 Aug - 23 Aug
9/10 Wonderful! (244 reviews)
"I have come across the best Marriott experience on earth. The customer service was inexplicable. It was incredible. I was treated like a President. The staff were friendly, professional, and most welcoming. I seriously cannot find words to describe the experience. I would like to go back to Santa ..."
Reviewed on 12 Aug, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Santa Cruz holiday package cost?
We make it simple to travel the world, with Santa Cruz holiday packages starting from as little as . You'll have the flexibility to combine your favourite airlines, hotels and car rental. For the ultimate getaway, why not add a couple of tours and activities to your itinerary?
How do I get a cheap travel package to Santa Cruz?
One of the easiest ways to save money (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all covered. Pick a combination that best fits you and watch your savings pile up. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 partner airlines and 1,000,000 properties across the world, which lets you customize your Santa Cruz adventure.
What are the top hotels in Santa Cruz?
For properties in Samaipata with cosy beds and friendly service, look up Sun Hotel and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel. If you're swinging by San Jose de Chiquitos as well, you'll get a great night's sleep at Camino Real Hotel or Marriott Santa Cruz de la Sierra Hotel.
How far in advance should I book my Santa Cruz holiday?
It's hard to pick the best time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to 12 months in advance. If you're booking late, don't stress. Discounted prices occasionally appear within a few weeks of departure dates.
What does an Expedia Santa Cruz travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your favourite combination. After you've made your booking, you can add on the exciting stuff like activities and tours. Our travel packages make it simple to create an exciting Santa Cruz escape.
What should I know before booking a Santa Cruz travel package?
Bundling your bookings into a Santa Cruz holiday package is the most convenient way to organise your trip. Not only that, you'll save just for combining your hotels, flights and car rentals. Once you've booked, why not add on a day tour or an activity?
Can I choose my airline with a Santa Cruz Expedia holiday package?
Yes — that's one of the best things about an Expedia package. You're in control. We have more than 550 airline partners throughout the world, so you have loads of choice when organising your Santa Cruz getaway.
If I'm not able to travel, can I cancel my Santa Cruz holiday package?
Yes you can, and we'll help you every step of the way. You may be able to change or cancel your Santa Cruz holiday package at no cost within 24 hours of booking. However, you may be charged a fee by your hotel, airline or car rental company if you booked more than 24 hours ago. If life throws you a curveball, browse our Customer Service Portal for more information.
Stay near popular Santa Cruz attractions
Plaza 24 de Septiembre
8.8/10 (164 reviews)
The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.
Ventura Mall
9.0/10 (183 reviews)
During your visit to Santa Cruz, you can enjoy retail therapy at Ventura Mall. Make some time to visit the cathedral while you're in the area.
Guembe Biocenter
8.8/10 (60 reviews)
Explore the great outdoors at Guembe Biocenter, a lovely green space in Colinas del Urubo. While in the area, you can find time to visit its shops.
Santa Cruz Zoo
8.4/10 (53 reviews)
Why not visit the animals who call Santa Cruz Zoo home during your travels in Santa Cruz? While in the area, you can find time to visit its shops.
Cine Center
8.0/10 (53 reviews)
You can make plans for a show at Cine Center on your trip to Santa Cruz. While in the area, you can find time to visit its shops.
Ramon Tahuichi Aguilera Stadium
8.4/10 (18 reviews)
Catch an event at Ramon Tahuichi Aguilera Stadium during your trip to Santa Cruz. While in the area, you can find time to visit its shops.
Lomas de Arena Regional Park
8.4/10 (28 reviews)
Explore the great outdoors at Lomas de Arena Regional Park, a lovely green space in Santa Cruz. While in the area, you can find time to visit its shops.
Plaza Principal San Jose de Chiquitos
Learn about the local history of San Jose de Chiquitos with a stop at Plaza Principal San Jose de Chiquitos. Amble around the area's forests or visit its churches.
What to do in Santa Cruz
Santa Cruz: Wildlife Sanctuary and Preservation Park Tour
S$110
per adult
Santa Cruz and Porongo: History, Markets, River, and Culture
S$84
per adult
Private Historical Expedition: The Che Legacy in Vallegrande
S$24
per adult
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.
