⭐ Top 10 Hotels Near Santee National Wildlife Refuge for 2026

A flooded area with trees standing in water.

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Our top choices for Santee National Wildlife Refuge hotels

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A gym with treadmills, weight machines, and a wall of dumbbells.

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

1. Hampton Inn Santee-I-95

7 km from Santee National Wildlife Refuge

sandra

S$167

includes taxes & fees

8 Nov - 9 Nov

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.

A reception desk with a wooden panel wall and a circular decorative piece above it.

2. Fairfield Inn & Suites by Marriott Santee

7 km from Santee National Wildlife Refuge

Victor

S$197

includes taxes & fees

8 Nov - 9 Nov

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

A modern lobby with a blue sofa, teal chairs, and a wooden table.

3. Tru By Hilton Santee

7.2 km from Santee National Wildlife Refuge

Connor

S$144

includes taxes & fees

8 Nov - 9 Nov

A hotel entrance with a sign reading "Best Western PLISS."

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

4. Best Western Plus Santee Inn

7 km from Santee National Wildlife Refuge

Johnny

S$169

includes taxes & fees

22 Nov - 23 Nov

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

5. Baymont by Wyndham Santee

7.2 km from Santee National Wildlife Refuge

Stephen

S$113

includes taxes & fees

27 Oct - 28 Oct

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

6. Comfort Inn & Suites Santee

7.2 km from Santee National Wildlife Refuge

Alexis

S$142

includes taxes & fees

22 Nov - 23 Nov

A water park with a pool, slides, and umbrellas.

A modern lounge area with seating, tables, and a fireplace.

A cobblestone street lined with colorful buildings, a palm tree, and flowering trees.

A hotel room with a bed, a desk, a chair, a sofa, and a television.

7. Holiday Inn Santee by IHG

7.2 km from Santee National Wildlife Refuge

Traci

S$156

includes taxes & fees

8 Nov - 9 Nov

A tent with a view of a lake and boats, a wooden chair, and a potted plant.

A modern room with a grey sofa, a small table, and a view of a lake and parked car through large glass doors.

A compact living space with a bunk bed, a kitchenette, and a control panel with a clock.

A modern, two-story mobile home with a metal exterior, large windows, and a visible kitchen area.

8. Bells Marina & Resort

19.5 km from Santee National Wildlife Refuge

Mark

S$109

includes taxes & fees

27 Oct - 28 Oct

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.

A kitchen with a countertop, cabinets, a microwave, and a sink.

A motel with a brick facade, a covered entrance, and a satellite dish.

9. Travelodge by Wyndham Santee

7.1 km from Santee National Wildlife Refuge

Robert

S$91

includes taxes & fees

27 Oct - 28 Oct

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A two-story building with a beige facade, large windows, and a central entrance.

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

10. Super 8 by Wyndham Santee/I-95

7 km from Santee National Wildlife Refuge

William

S$90

includes taxes & fees

2 Nov - 3 Nov

A hotel room with a bed, a black armchair, a round mirror with lights, a black vanity with a sink, and a white towel on the wall.

A modern room with a grey sofa, a small table, and a black countertop with a sink.

A television screen displaying the Hulu interface with the title "Reasonable Doubt" and the text "Season 2 premiere" and "Defense attorney Jax Stewart".

A building with a red roof and a covered entrance area. There are cars parked in front.

11. Starlight Stays

19.8 km from Santee National Wildlife Refuge

tevin

S$91

includes taxes & fees

27 Oct - 28 Oct

A cabin with a porch, surrounded by trees and a body of water.

A room with a stone wall, a sign reading 'Red Roof Inn', two leather chairs, a wooden floor, and a sliding glass door leading outside.

A reception area with a stone wall, two leather chairs, a counter with a digital device, and a sign for Red Roof Inn.

A kitchen with a long countertop, various appliances, and cabinets.

12. Red Roof Inn Santee

7 km from Santee National Wildlife Refuge

Sharyn

S$89

includes taxes & fees

1 Nov - 2 Nov

A hotel room with two beds, a desk, a chair, and a view of the hallway.

A gym with various exercise equipment, including treadmills, weight machines, and free weights.

A pool hall with multiple pool tables, a patterned carpet, and a television screen on the wall.

A hotel with a red roof, a UPS store, and blue lighting on the pillars.

13. Ramada by Wyndham Santee I-95

7.1 km from Santee National Wildlife Refuge

Stevenson

S$111

includes taxes & fees

27 Oct - 28 Oct

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A living room with a brown sofa set, a wooden coffee table, and a chandelier.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

14. Quality Inn & Suites Santee I-95

6.9 km from Santee National Wildlife Refuge

Louis

S$84

includes taxes & fees

16 Nov - 17 Nov

A building with a red roof, a yellow door, and a brick facade.

A reception area with a counter, framed pictures, and a clock on the wall.

A hotel room with two beds, a desk, a chair, a lamp, and a bathroom with a mirror and sink.

15. Econo Lodge Santee

7.1 km from Santee National Wildlife Refuge

Arthur

S$96

includes taxes & fees

16 Nov - 17 Nov

A buffet with various food items and utensils.

A reception area with a counter, a clock, a ceiling fan, and a potted plant.

A room with a sofa, a small table, a chair, and a patterned rug.

A stone building with a sign for George's Oriental Restaurant & Ice.

16. Sunset Inn Manning I 95

18.9 km from Santee National Wildlife Refuge

James

S$70

includes taxes & fees

26 Nov - 27 Nov

A hotel lobby with a reception desk, a staircase, and signs for restrooms and the office.

A gazebo with a wooden deck and a grill, surrounded by a grassy field and trees.

A room with a window overlooking a parking area, a shelf with various snacks, and a chair with a towel.

A hotel entrance with a covered walkway, large windows, and potted plants.

17. Ashburn Inn Manning I 95

18.8 km from Santee National Wildlife Refuge

S$88

includes taxes & fees

27 Oct - 28 Oct

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Compare top hotels near Santee National Wildlife Refuge

Hampton Inn Santee-I-95 7 km from Santee National Wildlife Refuge View	Fairfield Inn & Suites by Marriott Santee 7 km from Santee National Wildlife Refuge View	Tru By Hilton Santee 7.2 km from Santee National Wildlife Refuge View	Best Western Plus Santee Inn 7 km from Santee National Wildlife Refuge View	Baymont by Wyndham Santee 7.2 km from Santee National Wildlife Refuge View
9.6 Exceptional 1,002 reviews	9.8 Exceptional 1,001 reviews	9.2 Wonderful 998 reviews	8.8 Excellent 1,002 reviews	8.0 Very good 1,503 reviews
S$167 includes taxes & fees 8 Nov - 9 Nov	S$197 includes taxes & fees 8 Nov - 9 Nov	S$144 includes taxes & fees 8 Nov - 9 Nov	S$169 includes taxes & fees 22 Nov - 23 Nov	S$113 includes taxes & fees 27 Oct - 28 Oct

Top Santee National Wildlife Refuge Hotel Reviews

Tru By Hilton Santee

10/10 Excellent

"Great place. Clean and convenient."

Baymont by Wyndham Santee

8/10 Good

"Ok hotel for the price point"

Hampton Inn Santee-I-95

10/10 Excellent

"EVERYTHING about The Hampton Inn in Santee, SC is just perfect! I can't think of a single thing that could be improved or done better."

Comfort Inn & Suites Santee

10/10 Excellent

"Great hotel"

Holiday Inn Santee by IHG

10/10 Excellent

"👍👍👍👍👍"

SureStay Hotel by Best Western Manning

10/10 Excellent

"Nice and clean and quiet all night"

Travelodge by Wyndham Santee

8/10 Good

"Reasonably priced, clean place to stay during a stopover from Key West to Va."

Super 8 by Wyndham Manning

8/10 Good

"Clean room with a decent breakfast selection."

Ramada by Wyndham Santee I-95

8/10 Good

"The room we stayed in was clean.The only downside was that they were doing some remodeling to the place and a worker knocked on our door for some reason, don't know why he didn't speak English."

Other attractions near Santee National Wildlife Refuge

Pine Island

Commune with nature and explore the great outdoors at Pine Island during your travels in Summerton. While you're in the area, wander around the parks.

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Santee Indian Mound and Fort Watson Site

You can learn about the history of Summerton with a visit to Santee Indian Mound and Fort Watson Site. While you're in the area, wander around the parks.

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Santee State Park

8.0/10 (219 reviews)

You can take time to visit Santee State Park during your travels to Santee. While you're here, you can savour the top-notch restaurants.

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Santee Cooper Country Club

7.8/10 (94 reviews)

Enjoy a round of golf in Santee at Santee Cooper Country Club. While you're here, you can savour the top-notch restaurants.

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Santee National Golf Club

8.0/10 (74 reviews)

Enjoy a round of golf in Santee at Santee National Golf Club. While you're here, you can savour the top-notch restaurants.

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Santee Town Hall

Santee Town Hall is just one of the places to see in Santee, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savour the top-notch restaurants.

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Taw Caw Creek

6.6/10 (4 reviews)

Commune with nature and explore the great outdoors at Taw Caw Creek during your travels in Summerton. While you're in the area, wander around the parks.

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Taw Caw Creek Park

6.4/10 (6 reviews)

Explore the great outdoors at Taw Caw Creek Park, a lovely green space in Summerton. While you're in the area, wander around the parks.

See properties

Frequently asked questions

What's the area like around Santee National Wildlife Refuge?

Santee National Wildlife Refuge is located in a welcoming area of Summerton known for its array of dining options and golfing. You'll find 160 hotels and other accommodations within a few miles for a convenient home base.

What's the best hotel to stay near Santee National Wildlife Refuge?

Tru By Hilton Santee is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. It's located 4.5 mi (7.2 km) from Santee National Wildlife Refuge. Other good choices within a few miles include Baymont by Wyndham Santee and Fairfield Inn & Suites by Marriott Santee.

How many hotels should I expect to find near Santee National Wildlife Refuge?

Expedia has 160 hotels and other accommodation options a few miles from Santee National Wildlife Refuge.

If I need to cancel the hotel reservation for my stay near Santee National Wildlife Refuge, will I receive a refund?

Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of your booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to get the best options available near Santee National Wildlife Refuge.

Hotels near Santee National Wildlife Refuge

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Our top choices for Santee National Wildlife Refuge hotels

1. Hampton Inn Santee-I-95

2. Fairfield Inn & Suites by Marriott Santee

3. Tru By Hilton Santee

4. Best Western Plus Santee Inn

5. Baymont by Wyndham Santee

6. Comfort Inn & Suites Santee

7. Holiday Inn Santee by IHG

8. Bells Marina & Resort

9. Travelodge by Wyndham Santee

10. Super 8 by Wyndham Santee/I-95

11. Starlight Stays

12. Red Roof Inn Santee

13. Ramada by Wyndham Santee I-95

14. Quality Inn & Suites Santee I-95

15. Econo Lodge Santee

16. Sunset Inn Manning I 95

17. Ashburn Inn Manning I 95

Compare top hotels near Santee National Wildlife Refuge

Hampton Inn Santee-I-95

Fairfield Inn & Suites by Marriott Santee

Tru By Hilton Santee

Best Western Plus Santee Inn

Baymont by Wyndham Santee

Top Santee National Wildlife Refuge Hotel Reviews

Tru By Hilton Santee

Baymont by Wyndham Santee

Hampton Inn Santee-I-95

Comfort Inn & Suites Santee

Holiday Inn Santee by IHG

SureStay Hotel by Best Western Manning

Travelodge by Wyndham Santee

Super 8 by Wyndham Manning

Ramada by Wyndham Santee I-95

Other attractions near Santee National Wildlife Refuge

Pine Island

Santee Indian Mound and Fort Watson Site

Santee State Park

Santee Cooper Country Club

Santee National Golf Club

Santee Town Hall

Taw Caw Creek

Taw Caw Creek Park

Frequently asked questions