A calm lake reflecting trees with autumn foliage, a clear sky, and a distant shoreline.

Find Luxury Hotels in St. Charles

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check availability on St. Charles Luxury Hotels

Tonight
28 Aug - 29 Aug
Tomorrow
29 Aug - 30 Aug
This weekend
28 Aug - 30 Aug
Next weekend
4 Sept - 6 Sept

Our top choices for St. Charles luxury hotels

1. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
St. Charles
  • Indulge in lavish comfort at this St. Charles retreat featuring a full-service spa, seasonal pool, and 6 exceptional restaurants.
S$268
includes taxes & fees
7 Sept - 8 Sept
Ameristar Casino Resort and Spa

2. DoubleTree by Hilton Hotel St. Louis - Chesterfield

DoubleTree by Hilton Hotel St. Louis - Chesterfield
Chesterfield
  • Chesterfield hotel offers plush comforts with indoor tennis courts, dual pools, and premium bedding.
S$168
includes taxes & fees
19 Sept - 20 Sept
DoubleTree by Hilton Hotel St. Louis - Chesterfield

3. Drury Plaza Hotel St. Louis Brentwood

Drury Plaza Hotel St. Louis Brentwood
Brentwood
S$205
includes taxes & fees
6 Sept - 7 Sept
Drury Plaza Hotel St. Louis Brentwood

4. DoubleTree by Hilton St. Louis Airport

DoubleTree by Hilton St. Louis Airport
Woodson Terrace
S$176
includes taxes & fees
13 Sept - 14 Sept
DoubleTree by Hilton St. Louis Airport

5. Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel
Berkeley
S$189
includes taxes & fees
13 Sept - 14 Sept
Renaissance St. Louis Airport Hotel

6. Marriott St. Louis Airport

Marriott St. Louis Airport
Edmundson
S$216
includes taxes & fees
19 Sept - 20 Sept
Marriott St. Louis Airport

7. Hilton St. Louis Frontenac

Hilton St. Louis Frontenac
Frontenac
  • Upscale St. Louis retreat features pool, concierge, fine dining in prime business district.
S$217
includes taxes & fees
6 Sept - 7 Sept
Hilton St. Louis Frontenac

8. Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton
Clayton
S$228
includes taxes & fees
3 Sept - 4 Sept
Le Méridien St. Louis Clayton

9. Moonrise Hotel

Moonrise Hotel
Delmar Loop
  • Boutique retreat blends urban charm with luxury, from rooftop views to Egyptian cotton and rainfall showers.
S$191
includes taxes & fees
10 Sept - 11 Sept
Moonrise Hotel

10. The Cheshire

The Cheshire
Richmond Heights
S$232
includes taxes & fees
2 Sept - 3 Sept
The Cheshire
View all properties

Top St. Charles Hotel Reviews

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10/10 Excellent
"Very quiet comfortable beds"
Courtney 2-night trip
Posted 6 hours ago
Pear Tree Inn St. Louis Airport
Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent
"Daily breakfast was great and evening appetizers and drinks were a great benefit. Hotel was quiet and location made it easy to get to attractions."
Laurie 2-night trip
Posted 8 hours ago
Drury Plaza Hotel St. Louis Union Station
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

8/10 Good
"The guy who works at guess service when we check in Monday the 24 was very friendly and very helpful giving great recommendations. And the girl who checked us in Morgane was extremely friendly a very nice greeting but the black girl who checked us out on the 27 was not pleasant at all it was like she didn’t want to be there . Maybe she was having a bad day but she could care less Overall I would highly recommend the Hyatt"
Linda 3-night trip
Posted 10 hours ago
Hyatt Regency St. Louis at The Arch
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

8/10 Good
"Great breakfast and they had gluten free bagels and almond milk. I only have 4 stars because 7am lawn care is absurd. Already checking in late and being woke up at 7 by blowers right by the windows is unacceptable. And being told it is not up to them? It was on their property."
Jennifer 1-night trip
Posted 2 days ago
Country Inn & Suites by Radisson, St. Charles Historic District
Forest Park Hotel by MDR

Forest Park Hotel by MDR

8/10 Good
"Free parking, clean big room, with microwave and fridge and affordable."
Jennylyn 2-night trip
Posted 2 days ago
Forest Park Hotel by MDR
Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles

10/10 Excellent
"Good location in Saint Charles, MO. Plenty of restaurants near by. Breakfast was a 6 out of 10. Good evening drinks and snacks"
gregory 7-night trip
Posted 4 days ago
Embassy Suites by Hilton St. Louis St. Charles

Frequently asked questions

Are you looking for a luxury hotel for your stay in St. Charles?
During your visit, you might want to enjoy the casinos and shopping which St. Charles is known for.
What's the best luxury hotel in St. Charles?
Ameristar Casino Resort and Spa is a luxury hotel with 6 restaurants and 2 bars, and it's a popular choice for Expedia travellers looking for an elegant place to stay.
When can I expect good weather in St. Charles?
Planning for the weather is an important factor for making your trip to St. Charles a success, especially when you're splurging. The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for St. Charles is 1172 mm.
What's there to see and do in St. Charles?
When you're in St. Charles, enjoy exploring the sights and attractions here including Historic Main Street, Frontier Park and Katy Trail. If you have a little extra time during your trip, you might want to make a stop at Lewis & Clark Boathouse and Nature Center and St Charles Convention Center.

Explore a world of travel with Expedia