Top 10 Uptown Greenville Hotels of 2026

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Where to stay in Uptown Greenville

Find the best Uptown Greenville areas for the activities you enjoy most.

University District

While University District isn't home to many top sights, Dowdy–Ficklen Stadium and Williams Arena at Minges Coliseum are some notable places to visit nearby.

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Convention District

When in Convention District, you can plan a visit to University Commons and 11 Galleria, some noteworthy sights in the nearby area.

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Medical District

If you're looking for some top things to see and do in Medical District and surrounding area, you can visit Arlington Crossing and South Greenville Park.

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Westhaven

Westhaven might not have many top sights, but 11 Galleria and University Commons are two attractions nearby that you can check out.

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A cityscape with a dense forest in the foreground and a clear blue sky.

College View Historic District

If you're looking for some top things to see and do in College View Historic District and surrounding area, you can visit Williams Arena at Minges Coliseum and Dowdy–Ficklen Stadium.

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Top Uptown Greenville Hotel Reviews

Holiday Inn Greenville by IHG

10/10 Excellent

"Great place, comfortable rooms"

Staybridge Suites Greenville Medical Center by IHG

10/10 Excellent

"I don’t expect much from hotels anymore that’s why I so pleasantly surprised by our stay. Excellent check in, thorough, professional. Loved loved loved the social on a Monday evening. Who gives you dinner, free beer and wine, and home baked cookies. Rooms were huge with full kitchen, living room, office space, 2 queens and a large bath. Everything was modern and spotless. Linens were new and clean, beds were great and breakfast was outstanding. This is what hotels should strive to provide! Job well done by everyone!"

Country Inn & Suites by Radisson, Greenville, NC

8/10 Good

"The hotel front desk - Chance was super nice and friendly. The breakfast bar attendant - Millie, was very nice and Millie kept the breakfast bar full and clean. Mille would assist guests as needed, such as making their waffles for them and even taking the finished waffle to the guest. The breakfast bar had a nice variety of items to choose from. One side note: there needs to be a sign or something to let other guests know this a "shared" breakfast bar and they should not hog the whole bar by spacing their chosen items all along the bar and blocking other guests from utilizing it. This was a repeated numerous times by the same set of guests. The housekeeping was whole different story for us. While they were friendly when we talked to them and were accommodating in providing towels. However, the whole time we were there, 3 days, our room was never cleaned. I check when we arrived to verify there was daily housekeeping and new towels each day. The used/wet towels were never removed, the trash cans were never emptied and the beds were never straighten up. We did not request for them "not" to do the normal housekeeping. Upon check-out this was brought to the front desk as an issue. Definitely not what I would and have expected from this brand."

Frequently asked questions

What is Uptown Greenville like?

Travellers will be sure to find plenty to entertain them in Greenville's Uptown Greenville neighbourhood. Are you looking for Uptown Greenville travel tips? Make sure that you visit Greenville Museum of Art and Town Common while you're in the neighbourhood.

What's a favourite place to stay in Uptown Greenville?

Based on our traveller data, Hilton Garden INN Greenville University is one of the top choices for your stay in Uptown Greenville. This hotel is a short 3-minute walk from East Carolina University, and it offers a restaurant and a 24-hour fitness centre.

If I need to cancel my hotel reservation in Uptown Greenville, will I receive a refund?

Yes, the majority of hotel room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view top deals in Uptown Greenville.

What is there to do around this Greenville neighbourhood?

A few attractions you might want to check out while you're in Uptown Greenville are Greenville Museum of Art and Town Common. Shepherd Memorial Library - Carver Branch and North Pines are also worth a visit when you're out sightseeing in Greenville.

Hotels in Uptown Greenville

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Our top choices for Uptown Greenville hotels

1. Hilton Garden INN Greenville University

2. Holiday Inn Express Greenville by IHG

3. Homewood Suites By Hilton Greenville, NC

4. Staybridge Suites Greenville Medical Center by IHG

5. Residence Inn by Marriott Greenville

6. Fairfield Inn & Suites by Marriott Greenville

7. Courtyard Marriott Greenville

8. Best Western Plus Suites-Greenville

9. Hampton Inn Greenville

10. Quality Inn Greenville near University

11. Holiday Inn Greenville by IHG

12. Microtel Inn & Suites by Wyndham Greenville/University Medic

13. Candlewood Suites Greenville NC by IHG

14. Hilton Greenville

15. Super 8 by Wyndham Greenville

16. Motel 6 Greenville, NC – ECU-Medical Center

17. Comfort Inn & Suites Greenville Near East Carolina University

18. Econo Lodge Greenville near University

19. Affordable Suites Greenville

20. Economy Inn of Greenville, NC

Where to stay in Uptown Greenville

University District

Convention District

Medical District

Westhaven

College View Historic District

Top Uptown Greenville Hotel Reviews

Holiday Inn Greenville by IHG

Frequently asked questions

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