⭐ Top 10 Hotels Near 21c Museum Hotel for 2026

Q: What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its stunning river views and great live music scene. If you're looking for a convenient place to stay, take a look at the 272 hotels and other accommodation options you'll find within a mile.

Q: What's the best hotel to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Omni Louisville Hotel and Homewood Suites by Hilton Louisville Downtown, KY .

Q: How many hotels are there near 21c Museum Hotel?

Expedia has 272 hotels and other accommodation options within a mile from 21c Museum Hotel.

Q: If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best deals available near 21c Museum Hotel.

Q: What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row and Union Station. You can watch performances at Louisville Palace, Derby Dinner Playhouse and Headliners Music Hall if you're interested in local theatre.

Our top choices for 21c Museum Hotel hotels

Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Edward

includes taxes & fees

3 Jul - 4 Jul

Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

James

includes taxes & fees

14 Jun - 15 Jun

The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Thomas

includes taxes & fees

26 Jun - 27 Jun

Market Street Inn

2.1 km from 21c Museum Hotel

Anissa

includes taxes & fees

21 Jun - 22 Jun

21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

William

includes taxes & fees

28 Jun - 29 Jun

3 bars/lounges, cocktail bar, lobby lounge

Omni Louisville Hotel

Downtown Louisville, 0.8 km from 21c Museum Hotel

Cortney

includes taxes & fees

21 Jun - 22 Jun

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Sandy

includes taxes & fees

21 Jun - 22 Jun

Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from 21c Museum Hotel

Dana Jean

includes taxes & fees

30 Jun - 1 Jul

The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

Kate M

includes taxes & fees

28 Jun - 29 Jun

Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Lauren

includes taxes & fees

30 Jun - 1 Jul

Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Richard

includes taxes & fees

17 Jun - 18 Jun

DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Michele

includes taxes & fees

10 Jun - 11 Jun

Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

David

includes taxes & fees

5 Jul - 6 Jul

2 restaurants; breakfast and dinner served

Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Monica

includes taxes & fees

4 Jul - 5 Jul

4 restaurants; breakfast, lunch and dinner served

Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Jacqueline

includes taxes & fees

4 Jul - 5 Jul

Embassy Suites Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

Natali

includes taxes & fees

6 Jul - 7 Jul

Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Sompathana

includes taxes & fees

29 Jun - 30 Jun

Louisville Marriott Downtown

Downtown Louisville, 0.7 km from 21c Museum Hotel

Pete

includes taxes & fees

28 Jun - 29 Jun

Holiday Inn Express & Suites Louisville Downtown by IHG

Downtown Louisville, 0.3 km from 21c Museum Hotel

Chic

includes taxes & fees

28 Jun - 29 Jun

AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

paulin

includes taxes & fees

28 Jun - 29 Jun

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Compare popular hotels close to 21c Museum Hotel

Property	Property class	Guest rating
Hotel Distil, Autograph Collection	4.0 star property	9.6 Exceptional 469 reviews	View
Homewood Suites by Hilton Louisville Downtown, KY	3.0 star property	9.4 Exceptional 1,001 reviews	View
The Grady	4.0 star property	9.4 Exceptional 1,007 reviews	View
Market Street Inn	3.5 star property	9.8 Exceptional 121 reviews	View
21c Museum Hotel Louisville	4.5 star property	9.4 Exceptional 1,001 reviews	View

Top 21c Museum Hotel Hotel Reviews

21c Museum Hotel Louisville

10/10 Excellent

"Lovely experience, room was beautiful, clean, comfortable; staff was welcoming. Hotel was just lovely. We would definitely go back and highly recommend it to other travelers."

The Brown Hotel

8/10 Good

"The hotel is lovely, and the history really permeates. The pianist in the lobby was elegant, and our meal in the lobby restaurant was wonderful, both the food and the service. The room was large and comfortable, but it was very difficult to cool the room adequately with the air conditioning. It was also adjacent to two busy streets, and the traffic noise was not dampened by the windows much at all. Overall, it was a good stay."

Homewood Suites by Hilton Louisville Downtown, KY

8/10 Good

"The breakfast staff was excellent, overall the food good but the eggs were terrible! In general reception was good but when we checked in the receptionist was not very “positive “ nor was she welcoming. The young gentlemen and a younger lady (both evening and early AM hours) were fine but our check-in was very underwhelming. Nice location"

Galt House Hotel Trademark Collection by Wyndham

4/10 Poor

"What started off as a continuation of a great trip to Louisville quickly devolved when we checked into The Galt. Immediately, there was no where to pull in and check-in, so we had to park and come upstairs to the lobby. When we got checked in they put us in the tower across the street, but would only give us parking for the east tower. Every time we had to go to our car, we had to go up one floor, change elevators to go up to 3, go across the atrium to our building and into another elevator that went to our floor. When you're lugging around bourbon and luggage, this becomes a huge problem. Upon checking in, we loved our room and view, until I made the decision to shower. The shower was broken and there wasn't enough water pressure to rinse your hair out. It took 4 ignored maintenance requests for them to finally send somebody out... at 10pm. We had to leave our room at 10pm for an hour to get the part fixed, when our first communication started at 9am that morning. There was no apology until I texted again the final day when they asked about our stay and they comped my parking. While parking was awful too, my issue was with the basic amenity of a shower, not the price of parking. I came to scout out hotels for a long term business solution, and I definitely left with an answer of which one I won't return to, and not because there was an issue, but because of the response during and after."

Hotels near other 21c Museum Hotel attractions

Louisville Science Center

3.9/5 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

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Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its stunning river views and great live music scene. If you're looking for a convenient place to stay, take a look at the 272 hotels and other accommodation options you'll find within a mile.

What's the best hotel to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Omni Louisville Hotel and Homewood Suites by Hilton Louisville Downtown, KY.

How many hotels are there near 21c Museum Hotel?

Expedia has 272 hotels and other accommodation options within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best deals available near 21c Museum Hotel.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row and Union Station. You can watch performances at Louisville Palace, Derby Dinner Playhouse and Headliners Music Hall if you're interested in local theatre.

Hotels near 21c Museum Hotel

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Our top choices for 21c Museum Hotel hotels

Hotel Distil, Autograph Collection

Homewood Suites by Hilton Louisville Downtown, KY

The Grady

Market Street Inn

21c Museum Hotel Louisville

Omni Louisville Hotel

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Towneplace Suites By Marriott Louisville Downtown

The Brown Hotel

Cambria Hotel Louisville Downtown-Whiskey Row

Stellar Suites

DuPont Mansion Bed & Breakfast

Moxy Louisville Downtown

Tempo By Hilton Louisville Downtown Nulu

Galt House Hotel Trademark Collection by Wyndham

Embassy Suites Louisville Downtown

Aloft by Marriott Louisville Downtown

Louisville Marriott Downtown

Holiday Inn Express & Suites Louisville Downtown by IHG

AC Hotel Louisville Downtown

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

21c Museum Hotel Louisville

Hotels near other 21c Museum Hotel attractions

Louisville Science Center

Frequently asked questions