Calle 50
Visit Calle 50
Tours & day trips
See all 55 activities
City Sightseeing Panama City Hop-On Hop-Off Bus Tour
Adventure & outdoor
See all 20 activities
Live the Experience of a Full Day in San Blas
Private & custom tours
See all 11 activities
Private Night TOUR in PANAMA CITY
Cruises & boat tours
See all 7 activities
Panama Canal Partial Transit
Popular places to visit
Multiplaza Pacific Mall
During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Soho City Center
You can enjoy retail therapy at Soho City Center during your trip to Panama City. Discover the area's shops or seek out its local tours.
Avenida Balboa
You can browse for the perfect souvenirs at Avenida Balboa during your stay in Panama City. While you're in the area, wander around the natural setting.
Uruguay Street
During your visit to Panama City, you can search for that perfect souvenir at Uruguay Street. While in this family-friendly area, you can savour the top-notch restaurants.
Bingo 90
Why not roll the dice with a visit to Bingo 90 during your travels in Panama City? Visit the shops and casinos in this vibrant area.
Hospital Punta Pacífica
If Hospital Punta Pacífica is what brings you to town, hopefully you'll have a chance to explore more of Panama City.
Top Calle 50 Hotel Deals
Hotel Riu Plaza Panama
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Courtyard by Marriott Panama Multiplaza Mall
Las Americas Golden Tower Panama
W Panama
The Executive Hotel
Waldorf Astoria Panama
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Decapolis Hotel Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.