Calle 50
Visit Calle 50
Tours & day trips
See all 53 activities
City Sightseeing Panama City Hop-On Hop-Off Bus Tour
Private & custom tours
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Private Night TOUR in PANAMA CITY
Cruises & boat tours
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Panama Canal Partial Transit
Popular places to visit
Soho City Center
You can enjoy retail therapy at Soho City Center during your trip to Panama City. Discover the area's casinos or seek out its local tours.
Multiplaza Pacific Mall
During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Avenida Balboa
You can browse for the perfect souvenirs at Avenida Balboa during your stay in Panama City. While you're in the area, wander around the natural setting.
Uruguay Street
During your visit to Panama City, you can search for that perfect souvenir at Uruguay Street. While in this family-friendly area, you can savour the top-notch restaurants.
Bingo 90
Why not roll the dice with a visit to Bingo 90 during your travels in Panama City? Visit the casinos and shops in this vibrant area.
National Shrine of the Heart of Mary
You can learn about the history of Panama City with a trip to National Shrine of the Heart of Mary. Stroll along the seaside or visit the shops in this vibrant area.
Top Calle 50 Hotel Deals
Hotel Riu Plaza Panama
Megapolis Hotel Panamá
The Executive Hotel
Sheraton Grand Panama
Decapolis Hotel Panama City
Las Americas Golden Tower Panama
AC Hotel by Marriott Panama City
Courtyard by Marriott Panama Multiplaza Mall
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Explore a world of travel with Expedia
Explore a world of travel with Expedia
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- Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
- Ramada Plaza By Wyndham Panama Punta Pacífica
- Novotel Panama City
- Hospedium Princess Hotel Panama
- W Panama
- JW Marriott Panama
- Riande Urban Hotel
- Waldorf Astoria Panama
- Bristol Panama, a Registry Collection Hotel
- Holiday Inn Panama Distrito Financiero by IHG
- Plaza Paitilla Inn Hotel
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.