Hotels near Duke Regional Hospital

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24 Dec - 25 Dec
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Our top choices for Duke Regional Hospital hotels

Lobby
Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85
2.5 star property
2.2 km from Duke Regional Hospital
9.0 out of 10, Wonderful, (1003)
"Clean rooms and courteous staff."
United States
Katina
The price is S$154
includes taxes & fees
9 Jan - 10 Jan, 2026
Hampton Inn & Suites Durham/North I-85
Free buffet breakfast
Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG
2.5 star property
2.4 km from Duke Regional Hospital
8.8 out of 10, Excellent, (957)
"We arrived at 12:25am. We were welcomed warmly and it was a very nice and pleasant check-in. The staff member that checked us in was so great. "
United States
Timothy
The price is S$141
includes taxes & fees
1 Jan - 2 Jan, 2026
Holiday Inn Express Durham by IHG
Lobby
Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center
2.0 star property
2.3 km from Duke Regional Hospital
6.8 out of 10, (1000)
"Good motel...clean, easy acess "
United States
Howard
The price is S$87
includes taxes & fees
4 Jan - 5 Jan, 2026
Red Roof Inn Durham - Duke Univ Medical Center
Reception
Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center
2.5 star property
5 km from Duke Regional Hospital
9.6 out of 10, Exceptional, (401)
"Great breakfast, clean rooms and beds "
United States
Fabiola B
The price is S$166
includes taxes & fees
31 Dec - 1 Jan, 2026
Hampton Inn & Suites Durham University Medical Center
Garden
Arrowhead Inn

Arrowhead Inn

Arrowhead Inn
4.5 star property
8.9 km from Duke Regional Hospital
9.8 out of 10, Exceptional, (119)
"Bed was very comfortable, breakfast was yummy, and the surroundings were beautiful"
United States
Ronald
The price is S$286
includes taxes & fees
1 Jan - 2 Jan, 2026
Arrowhead Inn
Terrace/patio
JB Duke Hotel

JB Duke Hotel

JB Duke Hotel
4.0 star property
6.2 km from Duke Regional Hospital
9.4 out of 10, Exceptional, (543)
"Excellent on all levels! Will definitely stay here again!"
United States
Cherie Nan
The price is S$217
includes taxes & fees
25 Dec - 26 Dec
JB Duke Hotel
Indoor pool
Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club
4.0 star property
6.6 km from Duke Regional Hospital
9.4 out of 10, Exceptional, (1003)
"Everything fabulous!"
United States
Terri
The price is S$201
includes taxes & fees
18 Jan - 19 Jan, 2026
Washington Duke Inn & Golf Club
Meeting facility
Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center
3.0 star property
9th Street District, 4.1 km from Duke Regional Hospital
9.2 out of 10, Wonderful, (1001)
"Just right for an overnight business trip "
United States
Cody
The price is S$140
includes taxes & fees
4 Jan - 5 Jan, 2026
Hilton Garden Inn Durham/University Medical Center
Courtyard
Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr
3.0 star property
Trinity Park, 4.1 km from Duke Regional Hospital
9.2 out of 10, Wonderful, (460)
"Hotel was great - very friendly staff."
United States
Lisa
The price is S$204
includes taxes & fees
29 Dec - 30 Dec
Residence Inn Durham McPherson/Duke University Medical Cntr
BBQ/picnic Area
AC Hotel Durham

AC Hotel Durham

AC Hotel Durham
3.0 star property
5.4 km from Duke Regional Hospital
9.2 out of 10, Wonderful, (617)
"Room was very clean, staff very helpful and nice. "
United States
Tia
The price is S$172
includes taxes & fees
28 Dec - 29 Dec
AC Hotel Durham
Terrace/patio
SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View
3.5 star property
5.4 km from Duke Regional Hospital
9.2 out of 10, Wonderful, (455)
"Yess the room was spotless and clean the check in was smooth "
United States
Vonisha
The price is S$150
includes taxes & fees
28 Dec - 29 Dec
SpringHill Suites by Marriott Durham City View
Premium bedding, desk, blackout curtains, iron/ironing board
The Durham Hotel

The Durham Hotel

The Durham Hotel
4.0 star property
Downtown Durham, 4.5 km from Duke Regional Hospital
9.0 out of 10, Wonderful, (642)
"Great stay. Very nice boutique hotel. "
United States
nadav
The price is S$271
includes taxes & fees
27 Dec - 28 Dec
The Durham Hotel
Property amenity
Aloft Durham Downtown

Aloft Durham Downtown

Aloft Durham Downtown
3.0 star property
American Tobacco District, 4.9 km from Duke Regional Hospital
9.0 out of 10, Wonderful, (731)
"Very friendly staff, very clean and convenient location"
United States
Robert
The price is S$272
includes taxes & fees
11 Jan - 12 Jan, 2026
Aloft Durham Downtown
Property grounds
Rizzo Center, a Destination by Hyatt Hotel

Rizzo Center, a Destination by Hyatt Hotel

Rizzo Center, a Destination by Hyatt Hotel
4.0 star property
17 km from Duke Regional Hospital
9.6 out of 10, Exceptional, (1001)
"Breakfast was fabulous!"
United States
Cindy
The price is S$198
includes taxes & fees
26 Dec - 27 Dec
Rizzo Center, a Destination by Hyatt Hotel
Front of property – evening/night
University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center
2.0 star property
4.5 km from Duke Regional Hospital
8.8 out of 10, Excellent, (1000)
"Great place"
United States
Chase
The price is S$156
includes taxes & fees
25 Dec - 26 Dec
University Inn Durham next to Duke University Medical Center
Terrace/patio
The Colonial Inn, an Ascend Collection Hotel

The Colonial Inn, an Ascend Collection Hotel

The Colonial Inn, an Ascend Collection Hotel
4.0 star property
18.6 km from Duke Regional Hospital
9.6 out of 10, Exceptional, (265)
"The room was great. Very clean. The staff was absolutely amazing! 10 out of 10! "
United States
Stuart
The price is S$196
includes taxes & fees
14 Jan - 15 Jan, 2026
The Colonial Inn, an Ascend Collection Hotel
Premium bedding, desk, blackout curtains, iron/ironing board
Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University
2.5 star property
Croasdaile Farm Master, 3.3 km from Duke Regional Hospital
8.6 out of 10, Excellent, (1000)
"Friendly staff, clean room, nice breakfast"
United States
Jessica
The price is S$136
includes taxes & fees
2 Jan - 3 Jan, 2026
Comfort Inn & Suites Durham near Duke University
Outdoor pool, pool loungers
Hyatt Place Durham Southpoint

Hyatt Place Durham Southpoint

Hyatt Place Durham Southpoint
3.0 star property
16.1 km from Duke Regional Hospital
9.4 out of 10, Exceptional, (1003)
"Beautiful room and very clean. Staff were extremely nice on each shift. Will stay here again!"
United States
Jacoby
The price is S$178
includes taxes & fees
31 Dec - 1 Jan, 2026
Hyatt Place Durham Southpoint
Minibar, desk, blackout curtains, iron/ironing board
Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek
2.5 star property
18.2 km from Duke Regional Hospital
9.4 out of 10, Exceptional, (1000)
"Wonderful hotel "
United States
Robert
The price is S$160
includes taxes & fees
4 Jan - 5 Jan, 2026
Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek
Meeting facility
The Westin Raleigh-Durham Airport

The Westin Raleigh-Durham Airport

The Westin Raleigh-Durham Airport
4.0 star property
18.1 km from Duke Regional Hospital
9.4 out of 10, Exceptional, (280)
"Besides the last day of no electricity for the most part good stay"
United States
Chandra
The price is S$300
includes taxes & fees
2 Jan - 3 Jan, 2026
The Westin Raleigh-Durham Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Duke Regional Hospital Hotel Reviews

Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG

10/10 Excellent
"We arrived at 12:25am. We were welcomed warmly and it was a very nice and pleasant check-in. The staff member that checked us in was so great. "
Timothy 1-night trip
Posted 1 day ago
Holiday Inn Express Durham by IHG

Hotels near other Duke Regional Hospital attractions

Sennett's hole is a swimming hole accessed from the west point outpost on the eno river. There are lots of rocks to lounge on on one side, and a rope swing on the other. It's great spot to hang out!
Photo by Nikki Benson
Open Photo by Nikki Benson

West Point on the Eno

Explore the great outdoors at West Point on the Eno, a lovely green space in Durham. Attend a sporting event or visit the stunning cathedral in this family-friendly area.
See properties
Brightleaf is part of downtown Durham, NC's renaissance. Old tobacco warehouses have found new life as shops and restaurants.
Photo by Jeff Bechtel
Open Photo by Jeff Bechtel

Brightleaf Square

You can do some window-shopping at Brightleaf Square during your visit to Durham. Discover the lively festivals and stunning cathedral in this family-friendly area.
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Frequently asked questions

What's the area like around Duke Regional Hospital?
Duke Regional Hospital is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, take a look at the 11 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay close to Duke Regional Hospital?
Hampton Inn & Suites Durham/North I-85 is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. It's located 1.3 mi (2.2 km) from Duke Regional Hospital. Other good choices within a few miles include Comfort Inn & Suites Durham near Duke University and Holiday Inn Express Durham by IHG.
How many hotels can I expect to find near Duke Regional Hospital?
Expedia has 11 hotels and other accommodation options within a mile from Duke Regional Hospital.
If I need to cancel the hotel reservation for my stay near Duke Regional Hospital, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If your reservation is non-refundable, you may still be able to cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the filter option "fully refundable" to view the best deals near Duke Regional Hospital.
What can I see and do near Duke Regional Hospital?
You might want to spend some time browsing the exhibits at Museum of Life and Science, Nasher Museum of Art at Duke University or Bennett Place. While you're exploring, swing by American Tobacco Campus, Cameron Indoor Stadium and Wallace Wade Stadium to learn a bit about the area. You can watch performances at Carolina Theatre, Durham Performing Arts Center and Manbites Dog Theater if you're interested in local theatre.