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Find Greenville Spa Hotels from S$272

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Check availability on Greenville Hotels with Spa

Tonight
6 Dec - 7 Dec
Tomorrow
7 Dec - 8 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Top Hotels with Spa in Greenville

Spa
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (414)
"The staff were really sweet and responsive. The views from the rooms are breathtaking! "
United States
Krystal
The price is S$420
includes taxes & fees
4 Jan - 5 Jan, 2026
Grand Bohemian Lodge Greenville, Autograph Collection
Couples treatment room(s), body treatments, body wraps, body scrubs
Hotel Hartness

Hotel Hartness

4.0 star property
Greenville
9.8 out of 10, Exceptional, (624)
"Beautiful location, friendly staff"
United States
Andrew
The price is S$272
includes taxes & fees
21 Dec - 22 Dec
Hotel Hartness
Bar (on property)
Hotel Domestique

Hotel Domestique

4.0 star property
Travelers Rest
9.6 out of 10, Exceptional, (30)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is S$463
includes taxes & fees
1 Jan - 2 Jan, 2026
Hotel Domestique
Exterior
The Orchard Inn

The Orchard Inn

3.0 star property
Saluda
9.4 out of 10, Exceptional, (139)
"Friendly and helpful staff. Excellent breakfast."
United States
John E
The Orchard Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Greenville Hotel Reviews

Drury Inn & Suites Greenville

Drury Inn & Suites Greenville

10/10 Excellent
"Friendly staff, clean rooms, good food too!"
Jack 2-night trip
Posted 4 days ago
Drury Inn & Suites Greenville

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Frequently asked questions

Looking to holiday at a spa hotel in Greenville?
Treat yourself to some pampering and book a hotel with a spa. Travellers highly recommend Greenville for its array of shops and gourmet restaurants—your day tour starts here. Enjoy the live music and waterfalls during your holiday. Hotels with spas are a great way to take a break from your daily routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Greenville?
Grand Bohemian Lodge Greenville, Autograph Collection is a top spa hotel featuring a 24-hour fitness centre, a bar and a restaurant. Another popular spa hotel in Greenville is Hotel Hartness.
How many spa hotels will I find in Greenville?
Among Expedia's 683 accommodation options in Greenville, there are 2 spa hotels.
What's there to see and do in Greenville?
Take in the sights and attractions that Greenville offers with a visit to The Peace Center, The Children's Museum of the Upstate and Bon Secours Wellness Arena. If you have some spare time during your trip, you might want to check out Greenville Zoo and Fluor Field at the West End.
What is a Greenville spa hotel?
Spa hotels in Greenville have full on-site spas which offer services including facials and a selection of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on holiday.