Main Street

Liam Maguire's Irish Pub & Restaurant with outdoor seating and flower pots.
A restaurant named Martha's with outdoor seating and potted plants.
A large cruise ship on a calm sea with a person sitting on a bench in the foreground.
A marina with several boats docked, a person rowing a boat, and a house in the background.
A large house by the water with several boats.

Top Main Street Hotel Deals

Margaritaville Resort Cape Cod

Margaritaville Resort Cape Cod

4 out of 5
1225 Iyannough Rd Hyannis MA
Margaritaville Resort Cape Cod
Craigville Beach Inn

Craigville Beach Inn

2 out of 5
1338 Craigville Beach Rd Centerville MA
Craigville Beach Inn
Hyannis Plaza Hotel

Hyannis Plaza Hotel

2.5 out of 5
662 Main Street Hyannis MA
Hyannis Plaza Hotel
The Ocean View

The Ocean View

2.5 out of 5
966 Craigville Beach Road Centerville MA
The Ocean View
Hyannis Harbor Hotel

Hyannis Harbor Hotel

3.5 out of 5
213 Ocean St Hyannis MA
Hyannis Harbor Hotel
Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection

4 out of 5
135 Route 28 West Yarmouth MA
Uncommoner Hotel by Reverie Boutique Collection
Cape Sands Inn

Cape Sands Inn

2.5 out of 5
149 Main St - RT 28 West Yarmouth MA
Cape Sands Inn
Heritage House Inn on Cape Cod, an Ascend Collection Hotel

Heritage House Inn on Cape Cod, an Ascend Collection Hotel

2.5 out of 5
540 Old Colony Rd Hyannis MA
Heritage House Inn on Cape Cod, an Ascend Collection Hotel
Hyannis Travel Inn

Hyannis Travel Inn

2.5 out of 5
18 North St Hyannis MA
Hyannis Travel Inn
See all 5,938 properties in Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.