⭐ Top 10 Hotels Near Mayo Clinic Florida for 2026

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Our top choices for Mayo Clinic Florida hotels

A modern restaurant with a bar area, wooden ceiling, and large windows.

A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.

A modern lobby with a curved sofa, round coffee tables, and a large pillar.

A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

1. Hilton Jacksonville at Mayo Clinic near Beaches

0.8 km from Mayo Clinic Florida

Patricia

S$246

includes taxes & fees

17 Oct - 18 Oct

An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

2. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

Patricia

S$220

includes taxes & fees

17 Oct - 18 Oct

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

A modern kitchen with a bar area, seating, and a view of the outdoors.

A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.

A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

3. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

Michaelanne

S$213

includes taxes & fees

23 Oct - 24 Oct

A spacious lobby with a glass floor, a reception desk, and a view of the ocean.

A bar area with a view of the beach, wooden bar stools, and a counter with a menu display.

A multi-story hotel with a beach view, parking lot, and a nearby restaurant.

A cafe with a tropical mural, a coffee menu, and a variety of seating options.

4. Margaritaville Jacksonville Beach

5.9 km from Mayo Clinic Florida

Keisha

S$200

includes taxes & fees

1 Nov - 2 Nov

A covered entrance with a dark tiled floor, white columns, and a green bench.

A snack area with shelves stocked with various snacks and a sign reading "Welcome to Jacksonville Beach."

A gym with treadmills, elliptical machines, and dumbbells.

A large, multi-story hotel with a prominent entrance, a covered area with lights, and a star-shaped design on the facade.

5. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

4.2 km from Mayo Clinic Florida

Robert

S$171

includes taxes & fees

29 Oct - 30 Oct

A hotel room with a bed, a desk with a flat-screen TV, a chair, a window, and an air conditioning unit.

A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.

A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

A golf course with a water hazard and a bridge.

6. Holiday Inn Express Jacksonville Beach by IHG

4.6 km from Mayo Clinic Florida

Bobby

S$160

includes taxes & fees

18 Oct - 19 Oct

A lobby with a reception desk, seating area, and a staircase.

An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.

A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

A modern kitchen with a refrigerator, coffee machine, and a bakery display.

7. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

frances

S$139

includes taxes & fees

25 Oct - 26 Oct

A pool with a waterfall feature, surrounded by large rock formations.

A bar with a tiled roof, outdoor seating, and a view of the ocean.

A beachfront hotel with multiple balconies, a sandy beach, and ocean views.

A balcony with a view of the ocean, a chair, and a railing.

8. Hampton Inn Jacksonville Beach/Oceanfront

6.3 km from Mayo Clinic Florida

Hope

S$245

includes taxes & fees

27 Oct - 28 Oct

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.

An outdoor patio with a pool, wooden pergola, and seating area.

A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

9. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

gregory

S$179

includes taxes & fees

18 Oct - 19 Oct

A hotel lobby with a bar area, seating arrangements, and a reception desk.

A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.

A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.

An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

10. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Patsy

S$159

includes taxes & fees

11 Oct - 12 Oct

A terrace with wooden tables and chairs, overlooking a beach and a pier.

A modern living room with a sectional sofa, two round coffee tables, wicker chairs, and large windows with sheer curtains.

A spacious outdoor dining area with wooden tables and chairs, a bar with stools, and large windows offering a view of the ocean.

A bar area with wooden beams, wicker hanging lights, and a bar stocked with bottles.

11. Springhill Suites By Marriott Jacksonville Beach Oceanfront

5.8 km from Mayo Clinic Florida

MELISSA

S$252

includes taxes & fees

25 Oct - 26 Oct

A beach view with a long stretch of sand, a pier, and a residential area with houses and a swimming pool.

A hotel room with a bed, a sofa, a table with a vase, a lamp, a dresser, and a view of the beach.

A street with palm trees and a building with a sign for 'Pete's Bar'.

A room with a balcony, a sofa, a table with a vase, and a hanging light fixture.

12. Dune House Hotel & Spa

8 km from Mayo Clinic Florida

Kelly

S$350

includes taxes & fees

1 Nov - 2 Nov

A balcony with a view of the beach, a wooden walkway, and a chair.

A swimming pool with a curved design, surrounded by lounge chairs and umbrellas, with palm trees and a building in the background.

A modern dining area with a large island, multiple seating options, and large windows offering a view of the beach.

A hotel with a large building, multiple balconies, and beach chairs with umbrellas.

13. Courtyard by Marriott Jacksonville Beach Oceanfront

6.4 km from Mayo Clinic Florida

John

S$240

includes taxes & fees

14 Oct - 15 Oct

A beach with a sandy shore, waves, and buildings in the background.

A balcony with two green chairs and a small table, overlooking a beach and a boardwalk.

A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.

A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.

14. Best Western Oceanfront

5.7 km from Mayo Clinic Florida

Stephanie

S$190

includes taxes & fees

8 Oct - 9 Oct

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.4 Exceptional 604 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 662 reviews	View
Hilton Jacksonville at Mayo Clinic near Beaches	9.2 Wonderful 368 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,003 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,003 reviews	View

Top Mayo Clinic Florida Hotel Reviews

TownePlace Suites by Marriott Jacksonville East

10/10 Excellent

"Staff were very nice and helpful."

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent

"Chris at front desk check-in was most pleasant and professional. She offered very good suggestions regarding the area and best routes for getting to and from our business location. She’s a great brand representative."

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

8/10 Good

"Missed coffee in the room. Bad idea."

Best Western Oceanfront

8/10 Good

"Front staff kind.Out gate right to beach"

Hilton Jacksonville at Mayo Clinic near Beaches

10/10 Excellent

"The room was very clean and the staff was great. I truly enjoyed my stay!!"

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

10/10 Excellent

"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.

Where is the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels are there near Mayo Clinic Florida?

Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.

What can I see and do near Mayo Clinic Florida?

You can catch a show at SeaWalk Pavillion, Players by the Sea and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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Our top choices for Mayo Clinic Florida hotels

1. Hilton Jacksonville at Mayo Clinic near Beaches

2. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches