What is Midtown like?

Travellers are sure to enjoy a stay in St. Louis's Midtown neighbourhood. Make sure that you visit Chaifetz Arena and Washington Avenue Historic District as part of your Midtown travel plans.

Where is the best place to stay in Midtown?

Based on our traveller data, Element by Marriott St. Louis Midtown is one of the top choices for your stay in Midtown. This hotel is a short 6-minute walk from St. Louis University, and it offers free breakfast and an indoor pool.

How many hotels will I be able to find in the Midtown area?

If you're searching for places to stay in St. Louis, Expedia has something to meet your needs with 36 Midtown hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in Midtown, will I receive a refund?

Yes! Most hotel room reservations are refundable if you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of check in. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of booking. Add dates, click "Search", then use the filter option "fully refundable" to get top deals in Midtown.

What are the top things to see and do in Midtown?

Sights like Red Flag, Scott Joplin House State Historic Site and Museum of Contemporary Religious Art can be part of your cultural tour of Midtown. Chaifetz Arena and Washington Avenue Historic District are also a couple of places to visit in the neighbourhood. St. Louis Union Station, Hermann Stadium and .ZACK Theater are just a few of the places to visit in and around Midtown. While you're out sightseeing, Fubar and The Sovereign - St. Louis are a couple of additional sights to visit in St. Louis.

How can I get around Midtown and the greater St. Louis area?

Ready to get out and explore the city? Grand Station is the closest metro station.

Top 10 Midtown Hotels of 2026 | Expedia Singapore

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Our top choices for Midtown hotels

An outdoor patio area with seating, planters, and a grill.

1. Element by Marriott St. Louis Midtown

Midtown

Julie

includes taxes & fees

6 Dec - 7 Dec

An outdoor patio area with seating, a fire pit, and a grill.

2. Residence Inn by Marriott St Louis Downtown

Midtown

Kirsten

includes taxes & fees

22 Nov - 23 Nov

A rooftop terrace with outdoor seating, string lights, and a city skyline view.

3. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

0.8 km from Midtown

Stephanie

includes taxes & fees

22 Nov - 23 Nov

An indoor pool area with a hot tub, seating, and a stone wall.

4. Drury Plaza Hotel St. Louis Union Station

Downtown West, 1.5 km from Midtown

gina

includes taxes & fees

22 Nov - 23 Nov

A modern bar area with a wooden bar counter, black bar stools, and a large wall with city names.

5. Fairfield Inn & Suites by Marriott St. Louis Downtown

Downtown West, 1.3 km from Midtown

Pamela

includes taxes & fees

22 Nov - 23 Nov

A modern outdoor seating area with a fire pit, surrounded by wicker furniture and a landscaped garden.

6. Courtyard by Marriott St. Louis Downtown West

Downtown West, 1.1 km from Midtown

nadia

includes taxes & fees

24 Nov - 25 Nov

An indoor swimming pool with a hot tub, lounge chairs, and a brick wall with artwork.

7. Pear Tree Inn St. Louis Near Union Station

Downtown West, 1.2 km from Midtown

Samuwel

includes taxes & fees

29 Nov - 30 Nov

An outdoor dining area with a glass table and chairs, a neon sign, and a city view.

8. Aloft by Marriott St Louis Central West End

Central West End, 2.2 km from Midtown

Brittany

includes taxes & fees

22 Nov - 23 Nov

A Comfort Inn & Suites hotel with a modern design, featuring a covered entrance and a brick facade.

9. Comfort Inn & Suites Saint Louis Lafayette Square

The Gate, 2 km from Midtown

Michelle

includes taxes & fees

13 Dec - 14 Dec

A modern kitchen with a hexagonal tile backsplash, built-in appliances, and a central island.

10. Tru By Hilton St. Louis Downtown

Downtown West, 2.5 km from Midtown

Arthur

includes taxes & fees

11 Dec - 12 Dec

A bar area with high wooden ceilings, a large mural, and a variety of seating options including tables and bar stools.

11. 21C Museum Hotel St Louis

Downtown West, 2.1 km from Midtown

A.R.

includes taxes & fees

6 Dec - 7 Dec

A modern living room with a fireplace, sofas, a coffee table, and a bookshelf.

12. AC Hotel St. Louis Central West End

Central West End, 3.4 km from Midtown

Janice

includes taxes & fees

22 Nov - 23 Nov

An outdoor seating area with a fire pit, cushioned benches, and a covered patio with string lights.

13. Home2 Suites by Hilton St. Louis/Forest Park

The Grove, 3 km from Midtown

Ruth

includes taxes & fees

7 Dec - 8 Dec

A multi-story hotel with a prominent corner location, large windows, and a well-lit facade.

14. Embassy Suites by Hilton St. Louis Downtown

Downtown St. Louis, 3.1 km from Midtown

Megan

includes taxes & fees

10 Dec - 11 Dec

A spacious lobby with high arched ceilings, ornate columns, and a central fountain.

15. St. Louis Union Station Hotel, Curio Collection by Hilton

Downtown West, 1.7 km from Midtown

William

includes taxes & fees

26 Nov - 27 Nov

The exterior of the Clark & Bourbon hotel with a well-lit entrance, a marquee sign, and a landscaped planter area.

16. Live by Loews - St.Louis

Downtown St. Louis, 3 km from Midtown

brandon

includes taxes & fees

22 Nov - 23 Nov

A hot tub with a wooden deck, surrounded by a bamboo fence, and string lights.

17. The West End

Central West End, 2.2 km from Midtown

Adam

includes taxes & fees

15 Nov - 16 Nov

A multi-story building with a classic architectural style, featuring numerous windows and a brick facade.

18. Courtyard by Marriott St. Louis Downtown/Convention Center

Downtown St. Louis, 2.9 km from Midtown

Jackson

includes taxes & fees

23 Nov - 24 Nov

A rooftop terrace with wicker furniture, offering a city view.

19. Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis, 3.4 km from Midtown

Nicole

includes taxes & fees

13 Dec - 14 Dec

A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.

20. The Royal Sonesta Chase Park Plaza St. Louis

Central West End, 3.6 km from Midtown

Sara

includes taxes & fees

22 Nov - 23 Nov

View all properties

Compare popular hotels in Midtown

Property	Property class	Guest rating
Element by Marriott St. Louis Midtown	3.0 star property	8.8 Excellent 860 reviews	View
Residence Inn by Marriott St Louis Downtown	3.0 star property	7.6 Good 1,000 reviews	View
Drury Plaza Hotel St. Louis Union Station	3.0 star property	9.4 Exceptional 1,620 reviews	View
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton	4.0 star property	8.8 Excellent 1,168 reviews	View
Fairfield Inn & Suites by Marriott St. Louis Downtown	3.0 star property	9.2 Wonderful 1,000 reviews	View

Where to stay in Midtown

Find the best Midtown areas for the activities you enjoy most.

The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Old Courthouse to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

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A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

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A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

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A historic building with a green dome and adjacent modern high-rise buildings.

Central West End

Enjoy this relaxed area, the ultimate destination for a lazy afternoon. Browse unique stores, admire artworks and sip coffee at sidewalk tables shaded by trees.

See properties

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

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Top Midtown Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent

"This hotel is in walking distance to the Arch and to the Cardinals stadium. The staff are amazing- both professional and helpful."

Forest Park Hotel by MDR

10/10 Excellent

"Great location for the price. Conveniently close to incredible Italian restaurants on the Hill. The rooms were spacious and accommodating. Enjoyed being there. Comfortable and satisfying stay. One small thing-those coffee cups in the reception lounge were awfully small. Ha. But we'd do it again."

21C Museum Hotel St Louis

10/10 Excellent

"This is by far my favorite hotel. It is always clean, the staff is very kind and helpful, the gym and hot tub is SO COOL and huge. One of the most unique hotels I’ve ever stayed in. Rooms are very comfortable, they leave water, chocolates, and a robe for you. Sometimes they even give you a complimentary whiskey. The dinner menu isn’t as good as it used to be and breakfast is overpriced but the atmosphere truly makes up for it. Theres a museum on the second floor, a pool table, a really cool stairwell of colors and art. I would recommend this hotel 100x."

Ameristar Casino Resort and Spa

8/10 Good

"We were here for a wedding. Our room was very nice but my son’s bathroom was disgusting and not clean, they had to switch rooms and the only compensation they gave them was a food voucher. Not acceptable with blood and vomit not cleaned from previous guest. We expected more for this caliber of hotel."

Hotels in Midtown

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Our top choices for Midtown hotels

1. Element by Marriott St. Louis Midtown

2. Residence Inn by Marriott St Louis Downtown

3. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4. Drury Plaza Hotel St. Louis Union Station

5. Fairfield Inn & Suites by Marriott St. Louis Downtown

6. Courtyard by Marriott St. Louis Downtown West

7. Pear Tree Inn St. Louis Near Union Station

8. Aloft by Marriott St Louis Central West End

9. Comfort Inn & Suites Saint Louis Lafayette Square

10. Tru By Hilton St. Louis Downtown

11. 21C Museum Hotel St Louis

12. AC Hotel St. Louis Central West End

13. Home2 Suites by Hilton St. Louis/Forest Park

14. Embassy Suites by Hilton St. Louis Downtown

15. St. Louis Union Station Hotel, Curio Collection by Hilton

16. Live by Loews - St.Louis

17. The West End

18. Courtyard by Marriott St. Louis Downtown/Convention Center

19. Drury Plaza Hotel St. Louis at the Arch

20. The Royal Sonesta Chase Park Plaza St. Louis

Compare popular hotels in Midtown

Where to stay in Midtown

Downtown St. Louis

Clayton

St. Charles Historic District

Central West End

Creve Coeur

Top Midtown Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

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