Mississippi County Holidays

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    Save up to S$1,300 when you book a flight and hotel together*

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Top hotels in Mississippi County

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

2.5 out of 5
102 Drake St Charleston MO
Fully refundable
The price is S$95 per night from 30 Oct to 31 Oct
S$95
30 Oct - 31 Oct
includes taxes & fees
The Riverstone Hotel Charleston-Sikeston
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St Charleston MO
Fully refundableReserve now, pay when you stay
The price is S$85 per night from 2 Nov to 3 Nov
S$85
2 Nov - 3 Nov
includes taxes & fees
6.8/10 (680 reviews)
"Disappointing Experience with Bed Quality and Breakfast Needs improvement—noisy bed and very basic breakfast options I recently stayed at this property, and unfortunately, my experience fell short of expectations. The Room: The main issue during my stay was the quality of the bed. The bed frame and ..."

Reviewed on 24 Oct, 2026

Super 8 by Wyndham Charleston/Sikeston East MO
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is S$138 per night from 1 Nov to 2 Nov
S$138
1 Nov - 2 Nov
includes taxes & fees
9.6/10 Exceptional! (1,003 reviews)
"We had a two-room room king suite. The only complaint I had was that it took 5-10 minutes for the hot water to get hot. They did offer to give me points for a free stay if I wanted to sign-up for their rewards program. We will there next year when we go through Sikeston MO."

Reviewed on 27 Oct, 2026

Drury Inn & Suites Sikeston, MO
See all 112 properties in Mississippi County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Mississippi County holiday package cost?
The most affordable Mississippi County package is , so your dream getaway can become a reality — without spending an arm and a leg. Bundle flights, hotels, car rentals and more to create a package that matches your travelling style.
How do I get a cheap travel package to Mississippi County?
You'll save piles of cash if you bundle your flights, hotels and car rentals into a Mississippi County holiday package. Sometimes cheap means fewer options. But not with Expedia. We offer more than 550 partner airlines and 1,000,000 hotels across the world, so you'll always have plenty of variety to choose from. Want to save even more? Add some interesting activities to your package deal to unlock even more bargains! After all, travel is about more than simply getting to your destination.
What are the top hotels in Mississippi County?
East Prairie is one destination that most visitors to Mississippi County put on their itinerary. For a comfortable stay here, look up Super 8 by Wyndham Charleston MO and Quality Inn Charleston I-57.
How far in advance should I book my Mississippi County holiday?
Browse Expedia to compare airfares as soon as possible. In many cases, you can purchase a ticket up to 12 months prior to departure. If you don't see your preferred carrier, or you have to book last minute, fear not. Cheap fares to Mississippi County occasionally appear just weeks before the date of departure.
What does an Expedia Mississippi County travel package include?
That depends on what you're looking for. If you're travelling alone, you might decide to combine hotels and flights. Bringing the whole crew to Mississippi County? A travel package including rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility to build your own travel package.
What should I know before booking a Mississippi County travel package?
You'll enjoy amazing savings when you combine your flights, hotels and rental cars into a package. Plus, booking everything together will make your trip planning easier. So why waste your money or time? Whether you're organising a luxury romantic escape or a budget solo adventure, explore our holiday packages today.
Can I choose my airline with a Mississippi County Expedia holiday package?
Yes — that's the beauty of an Expedia package. You're the boss! We have access to more than 550 airline partners around the world, so you have loads of choice when organising your Mississippi County adventure.
If I'm not able to travel, can I cancel my Mississippi County holiday package?
Yes, you can. We totally understand that even the best-laid plans can fail, so we're happy to help if you have to make changes to your Mississippi County holiday package. It may be possible to cancel or amend your itinerary at no cost if you've booked within 24 hours. Your airline, hotel or car rental company may impose a fee if your booking was made more than 24 hours ago. Head to our Customer Service Portal for further information. Also, be sure to check your itinerary for the nitty-gritty on change fees.

Stay near popular Mississippi County attractions

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.