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Top Cities in Mississippi County

A sunset over a calm lake with tall trees reflected in the water.
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Charleston

Charleston
A tree-lined landscape with a river and fields.
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East Prairie

East Prairie

Check prices for these dates

This weekend
30 Oct - 1 Nov
Next weekend
6 Nov - 8 Nov

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Our top choices for Mississippi County hotels

A building with a fountain and flower beds in front.

1. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (443 reviews)
"Everything was great clean helpful Everything friendly."
United States
Kathleen
The price is S$95
includes taxes & fees
30 Oct - 31 Oct
The Riverstone Hotel Charleston-Sikeston
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (680 reviews)
"Breakfast was light but good"
United States
zandra
The price is S$85
includes taxes & fees
2 Nov - 3 Nov
Super 8 by Wyndham Charleston/Sikeston East MO
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

3. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (107 reviews)
"Great"
United States
Jackson
The price is S$94
includes taxes & fees
28 Oct - 29 Oct
Eagle Inn Charleston
A hotel lobby with a reception desk, seating area, and a large window.

4. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (296 reviews)
"Good service,nice stuff and no complaints"
United States
Santiago
The price is S$98
includes taxes & fees
15 Nov - 16 Nov
Quality Inn Cairo I-57
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi County Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

8/10 Good
"We had a two-room room king suite. The only complaint I had was that it took 5-10 minutes for the hot water to get hot. They did offer to give me points for a free stay if I wanted to sign-up for their rewards program. We will there next year when we go through Sikeston MO."
Byron E. Shryock 1-night trip
Posted 13 hours ago
Drury Inn & Suites Sikeston, MO

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