𝗧𝗢𝗣 𝟭𝟬 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 East Prairie (2026)

A tree-lined landscape with a river and fields.

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Our top choices for East Prairie hotels

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

1. Drury Inn & Suites Sikeston, MO

Sikeston

Tim

S$138

includes taxes & fees

29 Oct - 30 Oct

A building with a fountain and flower beds in front.

A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.

A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.

2. The Riverstone Hotel Charleston-Sikeston

Charleston

Kathleen

S$95

includes taxes & fees

17 Oct - 18 Oct

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

3. Hampton Inn Sikeston

Sikeston

Lori

S$153

includes taxes & fees

18 Oct - 19 Oct

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

4. Best Western Plus Sikeston I-55

Sikeston

Shelley

S$121

includes taxes & fees

15 Oct - 16 Oct

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

A kitchenette with a coffee machine, a kettle, and storage shelves.

A buffet with various food items, including omelets and baked goods, served in metal containers.

5. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

S$135

includes taxes & fees

18 Oct - 19 Oct

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

6. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

S$147

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

7. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Craig

S$90

includes taxes & fees

15 Oct - 16 Oct

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

8. TownePlace Suites by Marriott Sikeston

Sikeston

Rubin

S$159

includes taxes & fees

29 Oct - 30 Oct

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.

A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

9. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

William

S$85

includes taxes & fees

15 Oct - 16 Oct

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

10. Days Inn and Suites by Wyndham Sikeston

Sikeston

David

S$97

includes taxes & fees

1 Nov - 2 Nov

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

11. Comfort Inn & Suites Sikeston I-55

Sikeston

Kathryn

S$116

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A kitchen with wooden cabinets, a granite countertop, a built-in microwave, and a window with a view.

A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

12. Eagle Inn Charleston

Charleston

Jackson

S$95

includes taxes & fees

15 Oct - 16 Oct

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A reception area with a counter, a coffee machine, and seating.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.

13. Country Yard Inn and Suite

Sikeston

William

S$82

includes taxes & fees

9 Nov - 10 Nov

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.

A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.

A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.

14. Super 8 By Wyndham Marston

Marston

Brenda

S$82

includes taxes & fees

24 Oct - 25 Oct

A reception area with a reception desk, two blue armchairs, a round table, and a glass door leading outside.

A modern building with a covered entrance, a nameplate, and a landscaped area with shrubs and a street lamp.

A large indoor swimming pool with a tiled floor, surrounded by seating areas and tables.

A corridor with a vending machine displaying various beverages and a wall with hanging products.

15. Sleep Inn at Discovery Park of America

Union City

Ben

S$110

includes taxes & fees

8 Nov - 9 Nov

A modern hotel lobby with a reception desk, seating areas, and a large abstract art piece on the wall.

A hotel room with two beds, a desk, and a large window offering a view.

A modern office space with a long desk, two chairs, and a computer. There are multiple tables and chairs in the background, and a colorful striped artwork on the wall.

An indoor swimming pool with clear water, safety signs, and chairs around the pool.

16. Holiday Inn Express & Suites Union City by IHG

Union City

Kevin

S$179

includes taxes & fees

18 Oct - 19 Oct

A hotel lobby with a reception desk, seating area, and a large window.

A hotel room with a desk, chair, television, and a lamp.

A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

17. Quality Inn Cairo I-57

Cairo

Santiago

S$98

includes taxes & fees

2 Nov - 3 Nov

An outdoor seating area with a fire pit, cushioned chairs, and a metal fence.

A Hampton Inn hotel with a modern design, featuring a well-lit entrance and a clear signage.

A hotel lobby with a long counter, multiple seating areas, and a modern chandelier.

An indoor swimming pool with a no diving sign, lounge chairs, and a no diving sign at the bottom.

18. Hampton Inn Union City

Union City

Debra

S$155

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

19. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

Laura

S$83

includes taxes & fees

21 Oct - 22 Oct

A hotel dining area with a long counter, multiple tables, and chairs. There are curtains on the windows, a lamp, and a view of the outdoors.

A hotel room with a dining area, a sofa set, a TV mounted on the wall, and a patterned carpet.

A gym with treadmills, elliptical machines, and stationary bikes.

A hotel room with a large bed, a desk, a chair, and a bedside table.

20. Quality Inn Union City US 51

Union City

Terrence Peter

S$102

includes taxes & fees

8 Nov - 9 Nov

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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie

Top East Prairie Hotel Reviews

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"good, clean, affordable :)"

Sleep Inn at Discovery Park of America

8/10 Good

"Everything was nice. Bed very comfortable."

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Everything perfect. Drury Inns sweat the details."

Reelfoot Lake Inn

8/10 Good

"Dated but descent."

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"Easy parking, our bathroom sink was leaning forward and we had to place our soap in the sink so it didn't slide on the floor."

Holiday Inn Express & Suites Union City by IHG

10/10 Excellent

"It was the perfect stay."

Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent

"Clean, comfortable room. Nice staff and good breakfast choices."

Hampton Inn Union City

10/10 Excellent

"The room was pretty spacious and very clean with updated furniture. Breakfast was great!"

Quality Inn Union City US 51

8/10 Good

"No comments"

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO

S$83

21 Oct - 22 Oct

includes taxes & fees

7/10 Good! (687 reviews)

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO

S$85

21 Oct - 22 Oct

includes taxes & fees

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

S$97

1 Nov - 2 Nov

includes taxes & fees

Sleep Inn at Discovery Park of America

1111 BLue Heron Lane Union City TN

S$110

8 Nov - 9 Nov

includes taxes & fees

9.2/10 Wonderful! (438 reviews)

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

S$121

15 Oct - 16 Oct

includes taxes & fees

8.4/10 Very good! (1,000 reviews)

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

S$153

18 Oct - 19 Oct

includes taxes & fees

Frequently asked questions

What's the best place for a stay in East Prairie?

Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Days Inn and Suites by Wyndham Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.

If I need to cancel my hotel reservation in East Prairie, will I receive a refund?

Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.

How is it staying in East Prairie?

Visitors will definitely enjoy all that East Prairie has to offer. There are 36 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.

What are the top places to visit in East Prairie?

The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Columbus-Belmont State Park and Fort Defiance State Park in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.

What's the weather like in East Prairie?

The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

East Prairie Hotels from S$82

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in East Prairie

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for East Prairie hotels

1. Drury Inn & Suites Sikeston, MO

2. The Riverstone Hotel Charleston-Sikeston

3. Hampton Inn Sikeston

4. Best Western Plus Sikeston I-55

5. Holiday Inn Express & Suites Sikeston Southwest by IHG

6. Fairfield Inn & Suites by Marriott Sikeston

7. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8. TownePlace Suites by Marriott Sikeston

9. Super 8 by Wyndham Charleston/Sikeston East MO

10. Days Inn and Suites by Wyndham Sikeston

11. Comfort Inn & Suites Sikeston I-55

12. Eagle Inn Charleston

13. Country Yard Inn and Suite

14. Super 8 By Wyndham Marston

15. Sleep Inn at Discovery Park of America

16. Holiday Inn Express & Suites Union City by IHG

17. Quality Inn Cairo I-57

18. Hampton Inn Union City

19. Super 8 by Wyndham Sikeston/Miner Area

20. Quality Inn Union City US 51

Stay near popular East Prairie attractions

Big Oak Tree State Park

Learn more about East Prairie

Top East Prairie Hotel Reviews

Super 8 by Wyndham Sikeston/Miner Area

Sleep Inn at Discovery Park of America

Drury Inn & Suites Sikeston, MO

Reelfoot Lake Inn

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Hampton Inn Union City

Quality Inn Union City US 51

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Charleston/Sikeston East MO

Days Inn and Suites by Wyndham Sikeston

Sleep Inn at Discovery Park of America

Best Western Plus Sikeston I-55

Hampton Inn Sikeston

Frequently asked questions

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