𝗧𝗢𝗣 𝟭𝟬 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 East Prairie (2026)

A tree-lined landscape with a river and fields.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in East Prairie

Pet friendly

Apartment

Pool

Condo

Family friendly

Waterpark

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for East Prairie hotels

1. Drury Inn & Suites Sikeston, MO

Sikeston

Sally

S$138

includes taxes & fees

14 Sept - 15 Sept

2. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

S$143

includes taxes & fees

27 Sept - 28 Sept

3. Hampton Inn Sikeston

Sikeston

Jeffrey

S$147

includes taxes & fees

13 Sept - 14 Sept

4. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

S$146

includes taxes & fees

13 Sept - 14 Sept

5. Best Western Plus Sikeston I-55

Sikeston

Kevin

S$128

includes taxes & fees

3 Sept - 4 Sept

6. The Riverstone Hotel Charleston-Sikeston

Charleston

Bobby

S$94

includes taxes & fees

7 Sept - 8 Sept

7. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

France

S$84

includes taxes & fees

8 Sept - 9 Sept

8. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Sharika West

S$91

includes taxes & fees

1 Sept - 2 Sept

9. TownePlace Suites by Marriott Sikeston

Sikeston

Lauren

S$164

includes taxes & fees

6 Sept - 7 Sept

10. Days Inn and Suites by Wyndham Sikeston

Sikeston

Lori

S$96

includes taxes & fees

2 Sept - 3 Sept

11. Comfort Inn & Suites Sikeston I-55

Sikeston

Lakeysha

S$131

includes taxes & fees

20 Sept - 21 Sept

12. Super 8 By Wyndham Marston

Marston

Rachel

S$134

includes taxes & fees

31 Aug - 1 Sept

13. Eagle Inn Charleston

Charleston

Jackson

S$109

includes taxes & fees

31 Aug - 1 Sept

14. Country Yard Inn and Suite

Sikeston

William

S$88

includes taxes & fees

16 Sept - 17 Sept

15. Quality Inn Cairo I-57

Cairo

Susan

S$96

includes taxes & fees

18 Sept - 19 Sept

16. Sleep Inn at Discovery Park of America

Union City

Ben

S$120

includes taxes & fees

20 Sept - 21 Sept

17. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

Kevin

S$83

includes taxes & fees

7 Sept - 8 Sept

18. Country Hearth Inn & Suites Union City

Union City

Jade

S$90

includes taxes & fees

26 Sept - 27 Sept

19. Hampton Inn Union City

Union City

James

S$154

includes taxes & fees

6 Sept - 7 Sept

20. Quality Inn Union City US 51

Union City

Candace

S$102

includes taxes & fees

20 Sept - 21 Sept

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie

Top East Prairie Hotel Reviews

Reelfoot Lake Inn

10/10 Excellent

"clean room, nice lake view, very quiet area. Just a good decent place to stay. Not a fancy 5 star hotel, but well worth it to me. Great place....Thanks!"

Quality Inn Union City US 51

8/10 Good

"Pros: Excellent staff,Room was very spacious with a comfy bed and very quiet atmosphere Cons:Around edges of room floor was dirty.Wifi is awful and needs to be updated to better Internet service."

Sleep Inn at Discovery Park of America

10/10 Excellent

"The room was clean and had plenty of room for two adults. Breakfast was fine and kitchen staff very helpful. Same with the desk staff at check-in and check-out. We had some questions about the television, which were quickly resolved. Plenty of parking, pretty scenery, and lots of nearby activities that we unfortunately didn't have time to enjoy. Will stay again when we're in the area."

Best Western Plus Sikeston I-55

10/10 Excellent

"This place was very clean. We were given a 2nd floor room. I asked if there was an elevator. Yes. When we brought our things in to go to our room, we found the elevator was temporarily out of order. My friend cannot climb stairs. We were immediately given a 1st floor room close to an entrance near handicap parking. The room was clean. Comfortable beds. Good shower and tub. Excellent breakfast. I've never been to Sikeston before, but if I go again, I'll stay here."

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"Staff were friendly, room was nice and clean, the breakfast was delicious. Of the three hotels on this trip this was the best one."

Hampton Inn Sikeston

10/10 Excellent

"👍"

Hospitality House Union City I 69 / US 51

10/10 Excellent

"The room was very comfortable.. very clean.. needs new curtains through"

More cheap stays in East Prairie