Mississippi River
Visit Mississippi River
The Chemists’ Club Hotel
Reviewed on 24 Oct, 2025
INNSiDE by Meliá New York Nomad
Reviewed on 30 Oct, 2025
Grayson Hotel in the Unbound Collection by Hyatt
Reviewed on 31 Oct, 2025
Tours & day trips
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Evening Riverboat Jazz Cruise
Private & custom tours
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Airboat Adventures: Semi-Private Airboat Experience
Food, drink & nightlife
See all 88 activitiesEvening Riverboat Jazz Cruise
Adventure & outdoor
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Small-Group Manchac Swamp Kayak Tour
Holiday & seasonal tours
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New Orleans: French Quarter Ghost and Haunted House Tour
Popular places to visit
Bluff City Theater
Get tickets for a show at Bluff City Theater, a theatre with a story to tell in Hannibal. While in this family-friendly area, you can savour the top-notch restaurants.
Mark Twain Boyhood Home and Museum
Find out about the history of Hannibal with a stop at Mark Twain Boyhood Home and Museum. While in this family-friendly area, you can savour the top-notch restaurants.
Mark Twain Memorial Lighthouse
You can find out about the history of Hannibal with a trip to Mark Twain Memorial Lighthouse. While in this family-friendly area, you can savour the top-notch restaurants.
Mark Twain Cave
Explore the great outdoors at Mark Twain Cave, a lovely green space in Hannibal. While in this family-friendly area, you can savour the top-notch restaurants.
Mark Twain Cave and Cameron Cave
You can find out about the history of Hannibal with a visit to Mark Twain Cave and Cameron Cave. While in this trendy area, you can savour the top-notch restaurants.
Sawyer's Creek Fun Park
Explore the great outdoors at Sawyer's Creek Fun Park, a lovely green space in Hannibal. While in this walkable area, you can savour the top-notch restaurants.
Top Mississippi River Hotel Deals
Check availability on hotels close to Mississippi River
Renaissance St. Louis Airport Hotel
Clayton Plaza Hotel & Extended Stay
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Drury Plaza Hotel St. Louis at the Arch
Hyatt Regency St. Louis at The Arch
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Hollywood Casino & Hotel St. Louis
Motel 6 Hazelwood, MO
Pear Tree Inn St. Louis Airport
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