⭐ Top 10 Hotels Near Mississippi River for 2026

A bridge spanning a body of water with a city skyline in the background during sunset.

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Our top choices for Mississippi River hotels

A restaurant with a bar area, wooden flooring, checkered tablecloths, and a brick wall.

A row of multi-story buildings with a variety of storefronts, including a coffee shop and a restaurant.

A bedroom with a brick wall, a wooden bed, two bedside tables with lamps, and a ceiling fan.

A downtown area with a mix of historic and modern buildings, a prominent Mercantile Bank, and a view of a lake.

1. The Eagles Nest Inn

14.2 km from Mississippi River

Gary

S$150

includes taxes & fees

22 Sept - 23 Sept

A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.

A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.

An indoor swimming pool with a lifeguard chair, poolside chairs, and a table with chairs.

A hotel room with a bed, a desk, a chair, a sofa, and a TV mounted on the wall.

2. Sleep Inn & Suites Hannibal West

30.3 km from Mississippi River

Patricia

S$163

includes taxes & fees

11 Oct - 12 Oct

A gazebo with a table and benches, surrounded by trees and a body of water.

A hotel room with a bed, two sofas, a small table, a desk with a chair, a TV, and a potted plant.

A two-story building with a flat roof and a covered entrance. There are two cars parked in front, and a truck is visible on the left.

A hotel room with a bed, a desk, a chair, a television, a microwave, and a lamp.

3. River's Edge Motel

13.6 km from Mississippi River

Paul

S$120

includes taxes & fees

18 Sept - 19 Sept

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

A spacious hotel lobby with a central wooden table, seating, a treadmill, and a large potted plant.

A multi-level indoor pool area with a visible water slide, a towel rack, and a notice board.

A multi-level indoor pool area with a clear pool, multiple balconies, and a covered seating area.

4. Best Western On The River

25.3 km from Mississippi River

Raymond

S$162

includes taxes & fees

20 Sept - 21 Sept

A room with a beige leather sofa, a wooden coffee table, a floor lamp, and a patterned carpet.

A compact kitchen with a refrigerator, microwave, and sink.

A hotel room with a bed, two bedside lamps, a headboard, and a patterned carpet.

A historic building with a stone facade and multiple windows, featuring a sign about Tom Sawyer's fence.

5. Riverside Inn Hannibal

25.1 km from Mississippi River

Jack

S$282

includes taxes & fees

20 Sept - 21 Sept

A hotel room with a large bed, a desk with a computer, a television, and a bathtub.

A bar area with a long counter, multiple bottles, glasses, and a few chairs.

A multi-story hotel with a covered entrance and a sign indicating it is part of the Oak Hill Inn & Suites.

A hotel room with a sofa, armchair, small table, TV, dresser, and a bathtub.

6. Oak Hill Inn & Suites

71.8 km from Mississippi River

Denny

S$147

includes taxes & fees

27 Sept - 28 Sept

An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

A lobby with leather sofas, a fireplace, a flat-screen TV, and a reception desk.

A spacious dining area with wooden flooring and tables, surrounded by glass walls and wooden paneling.

A hotel entrance with a central fountain, large columns, and a clear sky.

7. Quality Inn & Suites Hannibal West

30 km from Mississippi River

Tom

S$122

includes taxes & fees

11 Oct - 12 Oct

A modern kitchen with wooden cabinets, a granite countertop, a coffee machine, a microwave, a toaster, and a refrigerator.

A compact living space with a dining table, two chairs, a sofa, a desk, and a kitchenette.

A lobby with a reception desk, seating area, and a staircase.

8. Heritage Hotel Quincy

47.8 km from Mississippi River

Dustine

S$105

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.

A hotel room with a bed, a dresser, a nightstand with a lamp, a framed map on the wall, and a carpeted floor.

An indoor swimming pool with clear blue water, a tiled floor, and a ceiling with square vents.

A spacious lobby with a blue sofa, round coffee table, and blue chairs. There is a reception desk and a seating area with a high ceiling and large windows.

9. Drury Inn & Suites St. Louis St. Peters

95.3 km from Mississippi River

Melanie

S$161

includes taxes & fees

4 Oct - 5 Oct

A modern lobby with orange seating, a flat-screen TV, and a stone accent wall.

A hotel pool area with a hot tub, lounge chairs, and a 'No Diving Allowed' sign.

A gym with treadmills, stationary bikes, and a weight machine.

A hotel room with two beds, a headboard, bedside lamps, a clock, and a window with curtains.

10. Drury Plaza Hotel St. Louis St. Charles

104 km from Mississippi River

Robert

S$214

includes taxes & fees

27 Sept - 28 Sept

A Holiday Inn Express & Suites building with a modern design, featuring a covered entrance and a landscaped area with trees.

A modern indoor space with a long white table, blue and orange chairs, a sofa with patterned cushions, and a coffee station.

A modern hotel corridor with a wooden reception desk, a staircase, and a snack bar with various packaged foods.

Two reception desks with a modern design, a blue geometric wall in the background, and a sign indicating the hotel name.

11. Holiday Inn Express and Suites Alton St Louis Area by IHG

110.6 km from Mississippi River

Chris

S$162

includes taxes & fees

18 Oct - 19 Oct

A hotel room with a bed, a desk with a computer, a TV, and a bathroom with a shower.

A hotel room with a bed, a desk with a chair, a television, and a dining area with chairs.

A hotel entrance with a sign reading "Quality Inn & Suites by Choice Hotels".

A modern kitchen with dark cabinets, a central island with bar stools, and pendant lighting.

12. Quality Inn & Suites Quincy - Downtown

47.8 km from Mississippi River

Steve

S$161

includes taxes & fees

18 Oct - 19 Oct

A modern dining area with a long table, colorful chairs, and decorative hanging lights.

A Hampton Inn & Suites hotel with a modern design, featuring a large entrance and a well-lit facade.

A hotel reception area with a counter, a poster, and a patterned carpet.

A hotel room with two beds, a flat-screen TV, a microwave, and a desk with a chair.

13. Hampton Inn & Suites St. Louis/Alton

110.3 km from Mississippi River

Kristen

S$189

includes taxes & fees

27 Sept - 28 Sept

A hot tub with a rocky backdrop and a mural.

A cozy log cabin interior with a fireplace, wooden furniture, and a television mounted on the wall.

An outdoor patio area with wooden furniture, string lights, and umbrellas.

A restaurant with wooden walls, a bar area, and multiple seating arrangements.

14. Stoney Creek Inn Quincy

46.5 km from Mississippi River

Kent

S$152

includes taxes & fees

20 Sept - 21 Sept

A hotel room with a bed, a sofa, a desk, and a lamp.

An indoor swimming pool with wooden walls, a tiled floor, and a sign indicating no diving is allowed.

A restaurant with multiple tables and chairs, an exit sign, and a counter area.

A hotel reception area with a wooden reception desk, a red chair, and a carpeted floor.

15. Comfort Inn & Suites - Hannibal

26.2 km from Mississippi River

Melanie

S$117

includes taxes & fees

20 Sept - 21 Sept

A brick building with a sign reading "Country Inn & Suites."

A spacious living room with a blue sofa, a white coffee table, and a striped armchair. There is a bookshelf filled with decorative items and a television on a wooden stand.

A modern kitchen with blue cabinetry, a central island with stools, pendant lighting, and a variety of kitchen appliances and utensils.

An indoor swimming pool with a tiled floor, a central window, and multiple chairs around the pool.

16. Country Inn & Suites by Radisson, St. Charles Historic District

103.7 km from Mississippi River

Susan Greening.

S$182

includes taxes & fees

11 Oct - 12 Oct

A wooden staircase with a handrail, a small table with a lamp, and a chair in a room with a door and windows.

A fireplace with decorative elements, framed pictures, and a vase of red flowers.

A cozy living room with a fireplace, a red armchair, a globe, and various framed pictures on the mantel.

A large, two-story house with a porch and a sign indicating 'ONE WAY'.

17. Garden House Bed and Breakfast

25.2 km from Mississippi River

Edward

S$131

includes taxes & fees

26 Sept - 27 Sept

A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

A compact kitchen with white cabinets, a microwave, a coffee maker, and a sink.

A modern living room with a grey sofa, a white armchair, a coffee table, and a patterned rug. There is a kitchen in the background with white cabinets and a black door.

A spacious bathroom with a large bathtub, a walk-in shower, and a vanity with a mirror.

18. Lighthouse Inn & Suites

25.8 km from Mississippi River

Connie

S$264

includes taxes & fees

20 Sept - 21 Sept

A staircase on a grassy hill with a sunset in the background.

A kitchen with white cabinetry, a central island, stainless steel appliances, and decorative items on shelves.

A two-story building with a porch, a sign reading 'Green Tree Inn,' and an American flag.

A wooden deck with outdoor furniture, a small table, and a view of a red building and trees.

19. The Green Tree Inn

95 km from Mississippi River

Karen

S$285

includes taxes & fees

23 Sept - 24 Sept

A modern reception area with a marble counter, a wooden panel with a light fixture, a fireplace, and a seating area with a sofa and chairs.

A Holiday Inn hotel with a modern facade, a covered entrance, and landscaped areas with shrubs.

A spacious lobby with a fireplace, seating area, and large windows.

An outdoor patio with tables and chairs, green umbrellas, and string lights.

20. Holiday Inn Quincy East by IHG

46.1 km from Mississippi River

Charles

S$178

includes taxes & fees

27 Sept - 28 Sept

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Compare popular hotels close to Mississippi River

Property	Property class	Guest rating
The Eagles Nest Inn	9.4 Exceptional 26 reviews	View
Sleep Inn & Suites Hannibal West	9.6 Exceptional 1,002 reviews	View
River's Edge Motel	9.0 Wonderful 387 reviews	View
Best Western On The River	8.8 Excellent 1,000 reviews	View
Riverside Inn Hannibal	9.6 Exceptional 196 reviews	View

Top Mississippi River Hotel Reviews

The Cheshire

8/10 Good

"Charming and quaint alternative to a Holiday Inn. It was renovated 10-15 years ago but not much care since then. The pool was allegedly open still (mid September) but when we looked out to go use it, there was debris in it and it wasn’t very inviting. The price was affordable and it was pet friendly, I only wish we could have experienced it during its heyday years ago when it was properly maintained and cleaned."

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

10/10 Excellent

"The ice/microwave rooms are weird and only on every other floor. The rooftop bar is excellent, as is the art!"

Drury Plaza Hotel St. Louis Union Station

8/10 Good

"The staff was stellar, answered questions before I thought of them, knew the area and were efficient, housekeeping staff offered help and suggestions and were a highlight but front desk staff was great too. The parking garage was adequate, but parking before you checked in wasn't great (they offered a few 15 minute stalls and most folks clogged up the entrance area after that, so a bit cramped), but the garage itself wasn't bad. Room was clean, was were the public areas. Overall a nice stay!."

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent

"Great location, very clean. Highly recommend!"

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

10/10 Excellent

"We will stay here again. Good bkfst, convenient. Nice pool & spa."

Clayton Plaza Hotel & Extended Stay

10/10 Excellent

"We enjoyed the hotel. Lobby was beautiful and staff was helpful."

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

10/10 Excellent

"Room was clean and comfy. Breakfast was Delicious 😋"

Ameristar Casino Resort and Spa

10/10 Excellent

"We only spent one night but the room was gorgeous the checking was easy and the employees were great. The food at the restaurants were also good and of course we did enjoy our time at the casino"

21C Museum Hotel St Louis

10/10 Excellent

"Great location, spacious room."

Other attractions near Mississippi River

Mark Twain Cave

8.8/10 (89 reviews)

You can find out about the history of Hannibal with a visit to Mark Twain Cave. While in this trendy area, you can savour the top-notch restaurants.

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Sawyer's Creek Fun Park

7.8/10 (16 reviews)

Explore the great outdoors at Sawyer's Creek Fun Park, a lovely green space in Hannibal. While in this walkable area, you can savour the top-notch restaurants.

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Lovers Leap

8.8/10 (171 reviews)

Find out about the history of Hannibal when you spend time at Lovers Leap. While in this walkable area, you can savour the top-notch restaurants.

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Sodalis Nature Preserve

Explore the great outdoors at Sodalis Nature Preserve, a lovely green space in Hannibal. While in this family-friendly area, you can savour the top-notch restaurants.

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Bluff City Theater

7.6/10 (5 reviews)

Get tickets for a show at Bluff City Theater, a theatre with a story to tell in Hannibal. While in this family-friendly area, you can savour the top-notch restaurants.

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Planters Barn Theater

8.8/10 (22 reviews)

Get tickets for a show at Planters Barn Theater, a popular theatre in Hannibal. While in this walkable area, you can savour the top-notch restaurants.

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Mark Twain Boyhood Home and Museum

9.0/10 (278 reviews)

Find out about the history of Hannibal with a stop at Mark Twain Boyhood Home and Museum. While in this family-friendly area, you can savour the top-notch restaurants.

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Jim's Journey: The Huck Finn Freedom Center

8.4/10 (33 reviews)

You can browse the exhibits at Jim's Journey: The Huck Finn Freedom Center, a museum with a story of its own, during your holiday in Hannibal. While in this family-friendly area, you can savour the top-notch restaurants.

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Frequently asked questions

What's the area like around Mississippi River?

Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.

What's the best hotel to stay close to Mississippi River?

Hollywood Casino & Hotel St. Louis is one of the top choices for your stay based on our traveller data, and this hotel offers a casino and 7 restaurants. You'll find it 65.7 mi (105.7 km) from Mississippi River. Other good options around the area include Hyatt Regency St. Louis at The Arch and Clayton Plaza Hotel & Extended Stay.

If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?

Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.

Hotels near Mississippi River

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Our top choices for Mississippi River hotels

1. The Eagles Nest Inn

2. Sleep Inn & Suites Hannibal West

3. River's Edge Motel

4. Best Western On The River

5. Riverside Inn Hannibal

6. Oak Hill Inn & Suites

7. Quality Inn & Suites Hannibal West

8. Heritage Hotel Quincy

9. Drury Inn & Suites St. Louis St. Peters

10. Drury Plaza Hotel St. Louis St. Charles

11. Holiday Inn Express and Suites Alton St Louis Area by IHG

12. Quality Inn & Suites Quincy - Downtown

13. Hampton Inn & Suites St. Louis/Alton

14. Stoney Creek Inn Quincy

15. Comfort Inn & Suites - Hannibal

16. Country Inn & Suites by Radisson, St. Charles Historic District

17. Garden House Bed and Breakfast

18. Lighthouse Inn & Suites

19. The Green Tree Inn

20. Holiday Inn Quincy East by IHG

Compare popular hotels close to Mississippi River

Top Mississippi River Hotel Reviews

The Cheshire

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis at the Arch

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Clayton Plaza Hotel & Extended Stay

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Ameristar Casino Resort and Spa

21C Museum Hotel St Louis

Other attractions near Mississippi River

Mark Twain Cave

Sawyer's Creek Fun Park

Lovers Leap

Sodalis Nature Preserve

Bluff City Theater

Planters Barn Theater

Mark Twain Boyhood Home and Museum

Jim's Journey: The Huck Finn Freedom Center

Frequently asked questions