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Hotels near Mississippi River

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Check prices for these dates

Next weekend
6 Nov - 8 Nov
In two weeks
13 Nov - 15 Nov

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Our top choices for Mississippi River hotels

A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.

1. Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1,001 reviews)
"Great stay- within walking distance of good restaurant and coffee shop. Breakfast included hot items with adequate seating."
United States
ELAINE
The price is S$176
includes taxes & fees
29 Nov - 30 Nov
Sleep Inn & Suites Hannibal West
A restaurant with a bar area, wooden flooring, checkered tablecloths, and a brick wall.

2. The Eagles Nest Inn

The Eagles Nest Inn
3.0 star property
14.2 km from Mississippi River
9.6 out of 10, Exceptional, (28 reviews)
"Cutest place to stay in Louisiana Missouri"
United States
Kimberly
The price is S$165
includes taxes & fees
2 Dec - 3 Dec
The Eagles Nest Inn
A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

3. Best Western On The River

Best Western On The River
2.5 star property
25.3 km from Mississippi River
8.8 out of 10, Excellent, (1,007 reviews)
"fun town to stay and visit"
United States
Wei
The price is S$162
includes taxes & fees
6 Nov - 7 Nov
Best Western On The River
A gazebo with a table and benches, surrounded by trees and a body of water.

4. River's Edge Motel

River's Edge Motel
2.0 star property
13.6 km from Mississippi River
8.8 out of 10, Excellent, (395 reviews)
"Nice location."
United States
Jeff
The price is S$128
includes taxes & fees
2 Nov - 3 Nov
River's Edge Motel
A room with a beige leather sofa, a wooden coffee table, a floor lamp, and a patterned carpet.

5. Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
25.1 km from Mississippi River
9.6 out of 10, Exceptional, (204 reviews)
"Very nice room and great view of the river. Very comfortable bed and very nice shower. Walking distance to so many restaurants and shops. We enjoyed our stay very much!"
United States
Christina
The price is S$268
includes taxes & fees
10 Nov - 11 Nov
Riverside Inn Hannibal
A modern kitchen with wooden cabinets, a granite countertop, a coffee machine, a microwave, a toaster, and a refrigerator.

6. Heritage Hotel Quincy

Heritage Hotel Quincy
2.0 star property
47.8 km from Mississippi River
8.6 out of 10, Excellent, (479 reviews)
"Clean room. Quiet and comfortable"
United States
GARY
The price is S$106
includes taxes & fees
2 Dec - 3 Dec
Heritage Hotel Quincy
A hotel room with a large bed, a desk with a computer, a television, and a bathtub.

7. Oak Hill Inn & Suites

Oak Hill Inn & Suites
2.5 star property
71.8 km from Mississippi River
9.2 out of 10, Wonderful, (1,000 reviews)
"It’s a great place to spend the night."
United States
Regina
The price is S$127
includes taxes & fees
2 Dec - 3 Dec
Oak Hill Inn & Suites
An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

8. Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
30 km from Mississippi River
8.0 out of 10, Very good, (1,001 reviews)
"Our go to hotel for years when we visit Hannibal."
United States
Gayle
The price is S$120
includes taxes & fees
29 Nov - 30 Nov
Quality Inn & Suites Hannibal West
A hot tub with a rocky backdrop and a mural.

9. Stoney Creek Inn Quincy

Stoney Creek Inn Quincy
2.0 star property
46.5 km from Mississippi River
8.6 out of 10, Excellent, (1,004 reviews)
"The hotel was rustic, clean, and a great place to stay."
United States
Kent
The price is S$142
includes taxes & fees
8 Nov - 9 Nov
Stoney Creek Inn Quincy
A hotel room with a bed, a sofa, a desk, and a lamp.

10. Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (771 reviews)
"Front desk helpful Clean rooms Great breakfast and lady fixing our breakfast was helpful and kept plenty of food ready for all"
United States
Jerry
The price is S$122
includes taxes & fees
16 Nov - 17 Nov
Comfort Inn & Suites - Hannibal
A modern reception area with a marble counter, a wooden panel with a light fixture, a fireplace, and a seating area with a sofa and chairs.

11. Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
3.0 star property
46.1 km from Mississippi River
8.8 out of 10, Excellent, (697 reviews)
"The hotel was in a great location with clean rooms."
United States
Colleen
The price is S$162
includes taxes & fees
29 Nov - 30 Nov
Holiday Inn Quincy East by IHG
A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

12. Lighthouse Inn & Suites

Lighthouse Inn & Suites
4.0 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (47 reviews)
"The room was very clean. It had a hot tub in it and it was also very clean and worked properly. We enjoyed our stay there."
United States
Connie
The price is S$249
includes taxes & fees
2 Nov - 3 Nov
Lighthouse Inn & Suites
A hotel lobby with a dining area, a bar, and a fireplace.

13. Fairfield Inn & Suites Quincy

Fairfield Inn & Suites Quincy
3.0 star property
46 km from Mississippi River
8.6 out of 10, Excellent, (364 reviews)
"Room was clean, the breakfast buffet had a lot options."
United States
Chris
The price is S$154
includes taxes & fees
8 Nov - 9 Nov
Fairfield Inn & Suites Quincy
A hotel room with a bed, a desk with a computer, a TV, and a bathroom with a shower.

14. Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown
2.5 star property
47.8 km from Mississippi River
8.8 out of 10, Excellent, (498 reviews)
"Great stay for a wedding in the area."
United States
Bryan
The price is S$186
includes taxes & fees
8 Nov - 9 Nov
Quality Inn & Suites Quincy - Downtown
A spacious lobby with a black leather sofa, a matching armchair, a coffee table, and a chandelier.

15. Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1,001 reviews)
"Excellent place to stay"
United States
Jared
The price is S$85
includes taxes & fees
3 Nov - 4 Nov
Motel 6 Hannibal, MO
A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.

16. Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
95.3 km from Mississippi River
9.6 out of 10, Exceptional, (1,004 reviews)
"All the people were very nice and talkative. The happy hour food was good and so were the cocktails. The hotel was clean and comfortable."
United States
Michael
The price is S$162
includes taxes & fees
22 Nov - 23 Nov
Drury Inn & Suites St. Louis St. Peters
A modern hotel with a flat roof, multiple windows, and a sign indicating it is a Super 8 hotel.

17. Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
2.0 star property
26.3 km from Mississippi River
7.2 out of 10, Good, (1,002 reviews)
"Clean, safe hotel and friendly staff"
United States
Julie
The price is S$92
includes taxes & fees
3 Nov - 4 Nov
Super 8 by Wyndham Hannibal
A hotel room with two beds, a wooden headboard, a nightstand with a phone, and a wall-mounted lamp.

18. Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal
2.0 star property
26.4 km from Mississippi River
7.4 out of 10, Good, (294 reviews)
"Pretty good place to stay at with a great price !!"
United States
Christian
The price is S$83
includes taxes & fees
10 Nov - 11 Nov
Days Inn by Wyndham Hannibal
A large indoor swimming pool with a lifeguard chair, poolside chairs, and a view of the outside through large windows.

19. Hampton Inn Keokuk

Hampton Inn Keokuk
2.5 star property
98.9 km from Mississippi River
8.8 out of 10, Excellent, (701 reviews)
"Great stay, clean rooms great breakfast"
United States
Ryan
The price is S$145
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn Keokuk
A modern lobby with orange seating, a flat-screen TV, and a stone accent wall.

20. Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
104 km from Mississippi River
9.6 out of 10, Exceptional, (1,003 reviews)
"Wonderful place to stay and great location!"
United States
Robert
The price is S$215
includes taxes & fees
15 Nov - 16 Nov
Drury Plaza Hotel St. Louis St. Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels close to Mississippi River

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.
Sleep Inn & Suites Hannibal West
2.5 star property
9.6
Exceptional
1,001 reviews
View
A restaurant with a bar area, wooden flooring, checkered tablecloths, and a brick wall.
The Eagles Nest Inn
3.0 star property
9.6
Exceptional
28 reviews
View
A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.
Best Western On The River
2.5 star property
8.8
Excellent
1,007 reviews
View
A gazebo with a table and benches, surrounded by trees and a body of water.
River's Edge Motel
2.0 star property
8.8
Excellent
395 reviews
View
A room with a beige leather sofa, a wooden coffee table, a floor lamp, and a patterned carpet.
Riverside Inn Hannibal
2.5 star property
9.6
Exceptional
204 reviews
View

Top Mississippi River Hotel Reviews

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

8/10 Good
"It was a lovely room, great location and I have no complaints. I would stay there again."
Margaretta 1-night trip
Posted 5 hours ago
Hyatt Regency St. Louis at The Arch

Other attractions near Mississippi River

Mark Twain Cave

8.8/10 (89 reviews)
You can find out about the history of Hannibal with a visit to Mark Twain Cave. While in this trendy area, you can savour the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best hotel to stay close to Mississippi River?
Hollywood Casino & Hotel St. Louis is one of the top choices for your stay based on our traveller data, and this hotel offers a casino and 7 restaurants. You'll find it 65.7 mi (105.7 km) from Mississippi River. Other good options around the area include Hyatt Regency St. Louis at The Arch and Clayton Plaza Hotel & Extended Stay.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.