A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

Find Luxury Hotels in Mytilene

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Mytilene Luxury Hotels

Tonight
26 Aug - 27 Aug
Tomorrow
27 Aug - 28 Aug
This weekend
28 Aug - 30 Aug
Next weekend
4 Sept - 6 Sept

Our top choices for Mytilene luxury hotels

Breakfast buffet
Front of property – evening/night
Front of property – evening/night
Room

1. Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel
Lesvos
  • Luxuriate in this Lesvos boutique haven where pillowtop beds meet spa indulgences, all within steps of the beach and local art.
S$239
includes taxes & fees
20 Sept - 21 Sept
Theofilos Paradise Boutique Hotel
Outdoor pool
Restaurant
Restaurant
Room

2. Heliotrope Hotels

Heliotrope Hotels
Lesvos
S$203
includes taxes & fees
30 Aug - 31 Aug
Heliotrope Hotels
Exterior
Reception
Room
Terrace/patio

3. Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat
Lesvos
  • Seaside luxury awaits at this Greek retreat, where beachfront bliss meets wellness indulgence with 3 indoor pools and a full-service spa.
S$217
includes taxes & fees
2 Sept - 3 Sept
Mythical Coast Wellness Retreat
Garden
Front of property
Property grounds
Balcony view

4. Loriet Hotel

Loriet Hotel
Lesvos
S$196
includes taxes & fees
20 Sept - 21 Sept
Loriet Hotel
Terrace/patio
Front of property
Terrace/patio
Room

5. Elysion Hotel

Elysion Hotel
Lesvos
  • Experience tranquil luxury and refined comfort at this 5-star seaside retreat with outdoor tennis courts and multiple dining options.
S$280
includes taxes & fees
26 Sept - 27 Sept
Elysion Hotel
View all properties

Top Mytilene Hotel Reviews

Frequently asked questions

Are you looking for a luxury hotel for your Mytilene holiday?
Mytilene has some interesting things to see and do including Port of Mytilene and Mytilini Castle, so you might want to take in the local sights during your visit.
What's the best luxury hotel in Mytilene?
Mythical Coast Wellness Retreat is a luxury hotel with 5 restaurants and 5 bars, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Elysion Hotel and Theofilos Paradise Boutique Hotel are two other upscale options for your stay.
When can I expect good weather in Mytilene?
Planning for the weather is a good way to make your trip to Mytilene relaxing and enjoyable, especially when you're splurging. The hottest months are usually August and July, with an average temperature of 25°C, while the coldest months are January and February, with an average of 11°C. Average annual precipitation for Mytilene is 873 mm.
What's there to see and do in Mytilene?
Take in the sights and attractions that Mytilene offers with a visit to Port of Mytilene, Mytilini Castle and Olive-press Museum of Archipelagos Society. If you have a little extra time during your trip, you might want to make a stop at Roman Aqueduct at Moria and Thermes Gera Hot Springs.