A large eye sculpture in a park surrounded by trees.

Find Luxury Hotels in Northeast Missouri

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check availability on Northeast Missouri Luxury Hotels

Tonight
2 Sept - 3 Sept
Tomorrow
3 Sept - 4 Sept
This weekend
4 Sept - 6 Sept
Next weekend
11 Sept - 13 Sept

Our top choices for Northeast Missouri luxury hotels

1. Hermann Hill

Hermann Hill
Hermann
S$515
includes taxes & fees
7 Sept - 8 Sept
Hermann Hill

2. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
Clayton
  • Ritz-Carlton elegance defines this St. Louis retreat with indulgent spa services and dining excellence.
S$816
includes taxes & fees
20 Sept - 21 Sept
The Ritz-Carlton, St. Louis

3. Moonrise Hotel

Moonrise Hotel
Delmar Loop
  • Boutique retreat blends urban charm with luxury, from rooftop views to Egyptian cotton and rainfall showers.
S$226
includes taxes & fees
7 Sept - 8 Sept
Moonrise Hotel

4. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
St. Charles
  • Indulge in lavish comfort at this St. Charles retreat featuring a full-service spa, seasonal pool, and 6 exceptional restaurants.
S$254
includes taxes & fees
21 Sept - 22 Sept
Ameristar Casino Resort and Spa

5. Live by Loews - St.Louis

Live by Loews - St.Louis
Downtown St. Louis
S$241
includes taxes & fees
3 Sept - 4 Sept
Live by Loews - St.Louis

6. Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark
Downtown St. Louis
S$260
includes taxes & fees
9 Sept - 10 Sept
Hilton St. Louis at the Ballpark

7. The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis
Central West End
  • Indulge in historic elegance at this St. Louis gem featuring 3 restaurants, a spectacular pool area, and luxurious rooms near Forest Park.
S$300
includes taxes & fees
8 Sept - 9 Sept
The Royal Sonesta Chase Park Plaza St. Louis

8. The Cheshire

The Cheshire
Richmond Heights
S$224
includes taxes & fees
13 Sept - 14 Sept
The Cheshire

9. Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton
Clayton
S$228
includes taxes & fees
6 Sept - 7 Sept
Le Méridien St. Louis Clayton

10. St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton
Downtown West
  • Experience grandeur in a historic hotel with 7 restaurants, seasonal pool, and concierge services in city centre St. Louis.
S$221
includes taxes & fees
20 Sept - 21 Sept
St. Louis Union Station Hotel, Curio Collection by Hilton
View all properties

Top Northeast Missouri Hotel Reviews

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

8/10 Good
"The front desk people were all helpful The garage for parking was fairly maintained And the breakfast was very good"
Todd 4-night trip
Posted 3 hours ago
Clayton Plaza Hotel & Extended Stay
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

10/10 Excellent
"Great breakfast buffet! Enjoyed the hot tub too!"
Albert 2-night trip
Posted 3 hours ago
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

10/10 Excellent
"All modern amenities with a touch of old world glam! Across from a beautiful walking/biking park and equipped with a beautiful pool, workout facility, comfortable beds, and several restaurants, all you need to have a wonderful travel experience!"
Eileen 1-night trip
Posted 2 days ago
The Royal Sonesta Chase Park Plaza St. Louis

Explore a world of travel with Expedia