Piazza Santo Spirito
Visit Piazza Santo Spirito
Tours & day trips
See all 379 activities
Florence Day Trip from Rome by Train, with Optional Uffizi Gallery
Private & custom tours
See all 125 activities
Road Trip in Tuscany
Shows & concerts
See all 19 activities
Florence: Pasta and Tiramisu Class with Unlimited Wine
Adventure & outdoor
See all 19 activities
Cinque Terre and Pisa Day Trip with optional Leaning Tower Ticket
Holiday & seasonal tours
See all 14 activities
From Florence: Small Group Wine Tasting Tour to Tuscany
Popular places to visit
Palatine Gallery
You can study the exhibits at Palatine Gallery, a museum with a story of its own, during your holiday in Florence. Amble around this vibrant area's riverfront or experience its acclaimed art galleries.
Pitti Palace
Head to the south bank of the Arno River to immerse yourself in some of the finest art galleries in Florence.
Brancacci Chapel
A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.
Santo Spirito Basilica
Learn about the local history of Florence when you take a trip to Santo Spirito Basilica. Stroll along the riverfront or visit the churches in this vibrant area.
Pitti Vintage
You can browse for the perfect souvenirs at Pitti Vintage during your trip to Florence. Stroll along the riverfront or visit the churches in this vibrant area.
Casa Guidi Museum
You can browse the exhibits at Casa Guidi Museum, a museum with a story of its own, during your trip to Florence. Discover the acclaimed art galleries and stunning cathedral in this vibrant area.
Top Piazza Santo Spirito Hotel Deals
Check availability on hotels close to Piazza Santo Spirito
The Social Hub Florence Lavagnini
Hotel Paris
The Social Hub Florence Belfiore
Hotel Calimala Florence
25hours Hotel Florence Piazza San Paolino
Palazzo Mannaioni Suites
B&B Hotel Firenze Pitti Palace al Ponte Vecchio
Hotel La Scaletta Al Ponte Vecchio
Grand Hotel Baglioni
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.