Hotels in Medical Center District
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Check prices for these dates
Our top choices for Medical Center District hotels

San Antonio Marriott Northwest Medical Center
San Antonio Marriott Northwest Medical CenterMedical Center District
8.6 out of 10, Excellent, (1008)
The price is S$137
includes taxes & fees
18 Dec - 19 Dec

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NWMedical Center District
8.4 out of 10, Very good, (3121)
The price is S$136
includes taxes & fees
16 Dec - 17 Dec

Fairfield Inn & Suites by Marriott San Antonio Medical Center
Fairfield Inn & Suites by Marriott San Antonio Medical CenterMedical Center District
9.0 out of 10, Wonderful, (1003)
The price is S$125
includes taxes & fees
23 Dec - 24 Dec

Drury Inn & Suites San Antonio Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical CenterMedical Center District
9.2 out of 10, Wonderful, (1292)
The price is S$137
includes taxes & fees
4 Jan - 5 Jan, 2026

SpringHill Suites by Marriott San Antonio Medical Center/NW
SpringHill Suites by Marriott San Antonio Medical Center/NWMedical Center District
8.8 out of 10, Excellent, (1001)
The price is S$154
includes taxes & fees
16 Dec - 17 Dec

Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San AntonioMedical Center District
8.8 out of 10, Excellent, (1003)
The price is S$136
includes taxes & fees
21 Dec - 22 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Medical Center District
Find the best Medical Center District areas for the activities you enjoy most.

Downtown San Antonio
Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

Uptown
If you're spending some time in Uptown, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

Far West Side
While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Stone Oak
Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista while you're in town.

Northwest Side
If you're spending some time in Northwest Side, Huebner Oaks and Convocation Center are top sights worth seeing.
Top Medical Center District Hotel Reviews

Omni La Mansion del Rio
10/10 Excellent
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