Hotels in Medical Center District

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Our top choices for Medical Center District hotels

San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center
3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1008)
"Clean rooms Staff very nice "
United States
Yolanda
The price is S$137
includes taxes & fees
18 Dec - 19 Dec
San Antonio Marriott Northwest Medical Center

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
Medical Center District
8.4 out of 10, Very good, (3121)
"The hotel is clean and the staff are great "
United States
mazen t
The price is S$136
includes taxes & fees
16 Dec - 17 Dec
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center
2.5 star property
Medical Center District
9.0 out of 10, Wonderful, (1003)
"Staff was super nice! "
United States
Fredric
The price is S$125
includes taxes & fees
23 Dec - 24 Dec
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1292)
"Great place to stay and visit "
United States
Harry
The price is S$137
includes taxes & fees
4 Jan - 5 Jan, 2026
Drury Inn & Suites San Antonio Northwest Medical Center

SpringHill Suites by Marriott San Antonio Medical Center/NW

SpringHill Suites by Marriott San Antonio Medical Center/NW
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1001)
"good staff. good stay"
United States
Divya
The price is S$154
includes taxes & fees
16 Dec - 17 Dec
SpringHill Suites by Marriott San Antonio Medical Center/NW

Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1003)
"Room was clean, staff was very friendly!!"
United States
Ray
The price is S$136
includes taxes & fees
21 Dec - 22 Dec
Courtyard by Marriott Medical Center San Antonio

Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3.0 star property
Medical Center District
6.8 out of 10, (1002)
"Easy check in"
United States
Violet
The price is S$88
includes taxes & fees
4 Jan - 5 Jan, 2026
Country Inn & Suites by Radisson, San Antonio Medical Center, TX

OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio
2.0 star property
Medical Center District
7.2 out of 10, Good, (225)
"Always great stay"
United States
Juan
The price is S$85
includes taxes & fees
31 Dec - 1 Jan, 2026
OYO Inn & Suites Medical Center San Antonio

Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center
2.0 star property
Medical Center District
7.2 out of 10, Good, (215)
"Clean, and accommodating room was very a very good Choice!!"
United States
Jessica
The price is S$80
includes taxes & fees
16 Dec - 17 Dec
Studio 6 San Antonio, Tx - Northwest Medical Center

Park Inn by Radisson

Park Inn by Radisson
2.0 star property
Medical Center District
7.2 out of 10, Good, (1005)
"Staff were amazing, and everything else was great too. "
United States
Maximilian
The price is S$95
includes taxes & fees
28 Dec - 29 Dec
Park Inn by Radisson

Studio 6 San Antonio, TX - Medical Center

Studio 6 San Antonio, TX - Medical Center
2.0 star property
Medical Center District
6.6 out of 10, (787)
"Staff and amenities "
United States
Keyshia
The price is S$77
includes taxes & fees
16 Dec - 17 Dec
Studio 6 San Antonio, TX - Medical Center

Atria Inn & Suites

Atria Inn & Suites
2.0 star property
Medical Center District
7.6 out of 10, Good, (276)
"Check-in was smooth, and the room was clean. It needs some repairs and the blanket was as thin as the sheet, but no complaints otherwise."
United States
Rachel
Atria Inn & Suites

Flex Studios

Flex Studios
2.5 star property
Medical Center District
6.0 out of 10, (497)
"heb is nearby. "
United States
Sayeed
The price is S$63
includes taxes & fees
16 Dec - 17 Dec
Flex Studios

Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center
2.0 star property
Medical Center District
6.0 out of 10, (1002)
"Staff courteous."
United States
Kathleeen
The price is S$65
includes taxes & fees
1 Jan - 2 Jan, 2026
Motel 6 San Antonio, TX - Northwest Medical Center

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3.0 star property
Downtown San Antonio, 13 km from Medical Center District
7.8 out of 10, Good, (3762)
"Had an amazing time at the hotel "
United States
Uriel
The price is S$131
includes taxes & fees
17 Dec - 18 Dec
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

Riverwalk Plaza

Riverwalk Plaza
4.0 star property
12.3 km from Medical Center District
8.2 out of 10, Very good, (6198)
"Very clean super friendly staff"
United States
Jenifer
Riverwalk Plaza

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
3.5 star property
Far West Side, 11.3 km from Medical Center District
9.0 out of 10, Wonderful, (1297)
"Beautiful location and great staff"
United States
Miguel
The price is S$162
includes taxes & fees
14 Jan - 15 Jan, 2026
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hotel Valencia Riverwalk

Hotel Valencia Riverwalk
4.5 star property
Downtown San Antonio, 12.1 km from Medical Center District
9.4 out of 10, Exceptional, (2244)
"Beautful hotel would definitely recommend "
United States
Christina Ashley
The price is S$187
includes taxes & fees
13 Jan - 14 Jan, 2026
Hotel Valencia Riverwalk

Hyatt Regency San Antonio Riverwalk

Hyatt Regency San Antonio Riverwalk
4.0 star property
Downtown San Antonio, 12.4 km from Medical Center District
9.2 out of 10, Wonderful, (1927)
"Great stay overall "
United States
Melissa
The price is S$278
includes taxes & fees
17 Dec - 18 Dec
Hyatt Regency San Antonio Riverwalk

Menger Hotel

Menger Hotel
3.5 star property
Downtown San Antonio, 12.6 km from Medical Center District
9.0 out of 10, Wonderful, (3580)
"Best little hotel in San Antonio "
United States
Michael
The price is S$153
includes taxes & fees
29 Dec - 30 Dec
Menger Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

Uptown

If you're spending some time in Uptown, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista while you're in town.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Convocation Center are top sights worth seeing.

Top Medical Center District Hotel Reviews

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Frequently asked questions

What is Medical Center District like?
Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighbourhood.
What's a favourite hotel to stay in Medical Center District?
Based on Expedia customer reviews, Drury Inn & Suites San Antonio Northwest Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and an indoor pool. Other favourite options in the area include SpringHill Suites by Marriott San Antonio Medical Center/NW and Fairfield Inn & Suites by Marriott San Antonio Medical Center.
How many hotels will I be able to find in Medical Center District?
Expedia has 122 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.
What can I see and do in this San Antonio neighbourhood?
USAA Corporate Office Headquarters, The San Antonio Art Institute and Cinemark San Antonio 16 are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.