Medical Center District

San Antonio

Photo by Linda Cronan

Popular places to visit

Things to do


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is S$134 per night from 29 Jan to 30 Jan
S$134
29 Jan - 30 Jan
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (3,158 reviews)
Great breakfast and very clean

Reviewed on 7 Jan, 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is S$167 per night from 16 Jan to 17 Jan
S$167
16 Jan - 17 Jan
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy a free local area shuttle, room service and a 24-hour fitness centre. Our guests praise the helpful ...
8.6/10 Excellent! (1,001 reviews)
Awesome

Reviewed on 5 Jan, 2026

San Antonio Marriott Northwest Medical Center
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
The price is S$256 per night from 18 Jan to 19 Jan
S$256
18 Jan - 19 Jan
includes taxes & fees
Stay at this luxury hotel in San Antonio. Enjoy free Wi-Fi, a full-service spa and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (2,342 reviews)
The hotel was great, however, I didn’t receive my free wine, was not offered upgrades nor any “perks” I was supposed to receive as part of my gold status.

Reviewed on 4 Jan, 2026

Hotel Valencia Riverwalk
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive San Antonio TX
The price is S$161 per night from 8 Feb to 9 Feb
S$161
8 Feb - 9 Feb
includes taxes & fees
Stay at this family-friendly hotel in San Antonio. Enjoy free Wi-Fi, free parking and 2 hot tubs. Our guests praise the pool and the helpful staff in their reviews. ...
8.8/10 Excellent! (1,357 reviews)
Great room, all the resort amenities were excellent especially the heated pool. Enjoyed the walking trails too. All the people staying there were respectful of others.

Reviewed on 8 Jan, 2026

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free Wi-Fi, room service and a 24-hour fitness centre. Our guests praise the restaurant and the ...
8/10 Very Good! (6,286 reviews)
Windows needed cleaning. Did not have a balcony but could see the river walk thru the smudged windows

Reviewed on 6 Jan, 2026

Riverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3 out of 5
303 Blum Street San Antonio TX
The price is S$137 per night from 14 Jan to 15 Jan
S$137
14 Jan - 15 Jan
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (3,816 reviews)
Good

Reviewed on 3 Jan, 2026

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

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Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Convocation Center are top sights worth seeing.

Northwest Side
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Shearer Hills - Ridgeview

While visiting Shearer Hills - Ridgeview, you might make a stop by sights like North Star Mall and San Pedro Driving Range & Par 3 Course.

Shearer Hills - Ridgeview
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Midtown

Unique features of Midtown include the river views and bars. Make a stop by San Antonio River or The DoSeum while you're exploring the area.

Midtown
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La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

La Cantera District
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Tobin Hill

Tobin Hill might not have many top sights, but San Antonio River and San Antonio Museum of Art are two attractions nearby that you can check out.

Tobin Hill
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Uptown

If you're spending some time in Uptown, San Antonio River and Marion Koogler McNay Art Museum are top sights worth seeing.

Uptown


Medical Center District