Medical Center District
San Antonio
Visit Medical Center District
Stay near popular Medical Center District attractions
Things to do
San Antonio Zoo Any Day Ticket
S$38
per adult
96% of travellers recommend
San Antonio: Fredericksburg Wineries Day Trip with Tastings
S$231
per adult
100% of travellers recommend
Dining at Hard Rock Cafe San Antonio
S$52
per traveller
74% of travellers recommend
San Antonio Small Group Premium Night Tour
S$146
per adult
92% of travellers recommend
San Antonio: Botanical Garden Admission Ticket
S$23
per adult
100% of travellers recommend
Top hotels in Medical Center District
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd San Antonio TX
The price is S$136 per night from 14 Jul to 15 Jul
S$136
14 Jul - 15 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very good! (3,494 reviews)
"I got the One Key credit card through Hotels.com because of the offer for $100 off on this reservation and the hotel staff said I could not pay for the room with the card because I didn't physically have it in hand. I had just gotten approved for it that day. How could I have had a physical card? ..."
Reviewed on 13 Jul, 2026
San Antonio Marriott Northwest Medical Center
3233 NW Loop 410 San Antonio TX
The price is S$168 per night from 26 Jul to 27 Jul
S$168
26 Jul - 27 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy room service, a 24-hour fitness centre and Wi-Fi (surcharge). Our guests praise the helpful staff ...
8.6/10 Excellent! (1,120 reviews)
"lRicky was great at the front desk and room service was excellent!"
Reviewed on 12 Jul, 2026
Drury Inn & Suites San Antonio Northwest Medical Center
9806 Interstate Hwy 10 W San Antonio TX
Fully refundableReserve now, pay when you stay
The price is S$137 per night from 21 Jul to 22 Jul
S$137
21 Jul - 22 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,392 reviews)
"Booked for 2 nights and we couldn’t be more pleased. Staff always had a smile on their face , friendly, professional and helpful. Our room looked and smell cleaned. Our rate included breakfast and dinner plus 3 free drinks. We plan on booking the same room next time we’re in town."
Reviewed on 13 Jul, 2026
Courtyard by Marriott Medical Center San Antonio
8585 Marriott Dr San Antonio TX
The price is S$136 per night from 8 Aug to 9 Aug
S$136
8 Aug - 9 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (1,016 reviews)
"Most of the staff were great except the desk clerk onThursday evening. She was quite rude even though I only asked for towels. She made me feels as if I was bothering her. All the other desk clerks were amazing! They were friendly and helpful. Even the maintenance man had superior customer ..."
Reviewed on 11 Jul, 2026
Drury Plaza Hotel San Antonio Riverwalk
105 S Saint Marys Street San Antonio TX
The price is S$195 per night from 20 Jul to 21 Jul
S$195
20 Jul - 21 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and 2 hot tubs. Our guests praise the breakfast and the pool in their reviews. ...
9.4/10 Exceptional! (4,915 reviews)
"Very clean rooms and friendly staff. They even let my kiddos pick out a toy at check in. Valet was super easy and convenient as well. Breakfast was really good. We will be back!! :)"
Reviewed on 13 Jul, 2026
Riverwalk Plaza
100 Villita Street San Antonio TX
The price is S$131 per night from 14 Jul to 15 Jul
S$131
14 Jul - 15 Jul
includes taxes & fees
Stay at this family-friendly hotel in San Antonio. Enjoy free Wi-Fi, room service and a 24-hour fitness centre. Our guests praise the restaurant and the helpful ...
8/10 Very good! (6,501 reviews)
"Clean rooms. Friendly staff"
Reviewed on 12 Jul, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check Medical Center District hotel availability
Where to stay in Medical Center District
Find the best Medical Center District areas for the activities you enjoy most.
Downtown San Antonio
A scenic riverfront great entertainment and top sights from San Antonio River to Alamo – discover Downtown San Antonio, a destination also famous for its historic sites.
Far West Side
While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.
Photo by Sarah C.
Open Photo by Sarah C.
Uptown
If you're spending some time in Uptown, San Antonio Zoo and Aquarium and San Antonio River are top sights worth seeing.
La Cantera District
If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.
Stone Oak
Stone Oak is known for its abundant dining options, and you can plan a trip to Stone Ridge Market and Shops at Hardy Oak while you're in town.
