Hotels in Santa Ana

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Our top choices for Santa Ana hotels

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (68 reviews)
"We live this property and stay here whenever we are in town."
United States
chris
Casco View Apartments

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (59 reviews)
"Excelente "
Mexico
David
Hostal La Cigarra

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15 reviews)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is S$128
includes taxes & fees
4 Feb - 5 Feb
La Manzana by Wynwood House

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (183 reviews)
"Super outdated. Looks dangerous in the area"
United States
Nina Kristine
Hotel República

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (4,921 reviews)
" Nice hotel and great location "
United States
Wajdi
The price is S$192
includes taxes & fees
1 Mar - 2 Mar
Hotel Riu Plaza Panama

Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina
3.0 star property
El Cangrejo, 3.8 km from Santa Ana
7.4 out of 10, Good, (285 reviews)
"Good room - clean and quiet, Hotel location is on a commercial street with many restaurants and bars nearby and within walking distance to a metro station. "
Canada
P
The price is S$101
includes taxes & fees
5 Feb - 6 Feb
Ramada Panama Centro Via Argentina

Hospedium Princess Hotel Panama

Hospedium Princess Hotel Panama
3.5 star property
Obarrio, 3.6 km from Santa Ana
7.4 out of 10, Good, (754 reviews)
"Very polite staff and great service "
United States
Scot Da
The price is S$71
includes taxes & fees
8 Feb - 9 Feb
Hospedium Princess Hotel Panama

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
19.8 km from Santa Ana
8.6 out of 10, Excellent, (1,858 reviews)
"Very nice staff and confortable stay"
United States
MARIA
The price is S$175
includes taxes & fees
11 Feb - 12 Feb
Riande Aeropuerto Hotel & Casino

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
4.5 star property
Obarrio, 4.1 km from Santa Ana
8.8 out of 10, Excellent, (1,004 reviews)
"Great hotel"
United States
Hugh
The price is S$222
includes taxes & fees
22 Feb - 23 Feb
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Riande Urban Hotel

Riande Urban Hotel
3.5 star property
El Cangrejo, 3.8 km from Santa Ana
8.8 out of 10, Excellent, (1,055 reviews)
"Clean spacious room and friendly staff"
United States
Leslie
The price is S$118
includes taxes & fees
5 Feb - 6 Feb
Riande Urban Hotel

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
4.0 star property
21.1 km from Santa Ana
8.6 out of 10, Excellent, (2,409 reviews)
"Very nice hotel and good restaurant "
United States
Allen
The price is S$162
includes taxes & fees
23 Feb - 24 Feb
Crowne Plaza Panama Airport by IHG

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
4.0 star property
Punta Paitilla, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (1,005 reviews)
"excellent room and location"
United States
Jon
The price is S$216
includes taxes & fees
9 Feb - 10 Feb
Las Americas Golden Tower Panama

Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
Punta Paitilla, 3.5 km from Santa Ana
8.4 out of 10, Very good, (1,403 reviews)
"Clean room,helpful staff around the hotel,good food options"
United States
Umar
Megapolis Hotel Panamá

MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel
3.5 star property
Amador, 4.8 km from Santa Ana
8.2 out of 10, Very good, (219 reviews)
"Great rooms, pleasant staff, lovely location, lots of eats and drinks options"
United States
Rajiv Sachin
The price is S$97
includes taxes & fees
4 Feb - 5 Feb
MARINN Tropical Vibes Hotel

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2,163 reviews)
"Breakfast buffet was great. "
United States
Carol
The price is S$129
includes taxes & fees
5 Feb - 6 Feb
Plaza Paitilla Inn Hotel

JW Marriott Panama

JW Marriott Panama
5.0 star property
Punta Pacifica, 4.3 km from Santa Ana
9.0 out of 10, Wonderful, (1,006 reviews)
"Beautiful hotel, great service. Breakfast buffet is amazing. "
United States
Tamara
The price is S$390
includes taxes & fees
6 Mar - 7 Mar
JW Marriott Panama

ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport
2.5 star property
20.5 km from Santa Ana
9.0 out of 10, Wonderful, (63 reviews)
"Clean room, friendly staff."
United States
Richard
The price is S$198
includes taxes & fees
5 Feb - 6 Feb
ORHO HOTEL BOUTIQUE PANAMA Airport

The Executive Hotel

The Executive Hotel
3.5 star property
Campo Alegre, 3.2 km from Santa Ana
9.2 out of 10, Wonderful, (1,012 reviews)
"Breakfast was excellent, Rooms are lovely "
United States
Kera Michele Naomi
The Executive Hotel

Victoria Hotel and Suites Panama

Victoria Hotel and Suites Panama
3.5 star property
El Cangrejo, 3.5 km from Santa Ana
8.2 out of 10, Very good, (1,002 reviews)
"Staff was amazing, my second time staying at the hotel and I'll definitely be back "
United States
Paula
The price is S$101
includes taxes & fees
4 Feb - 5 Feb
Victoria Hotel and Suites Panama

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este, 10.2 km from Santa Ana
9.4 out of 10, Exceptional, (204 reviews)
"Excellent space, great layout, friendly staff, responsive staff. Will stay there again. "
United States
Nick
The price is S$174
includes taxes & fees
2 Mar - 3 Mar
Arcadia Condo Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Cinta Costera and Avenida Balboa while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Expedia customers rank Hostal La Cigarra the highest for a stay in Santa Ana.
How many hotels can I expect to find in Santa Ana?
Expedia has 110 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighbourhood. Albrook Shopping Mall, Amador Theater and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.