Hotels in Santa Ana

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Check prices for these dates

Tonight
19 Dec - 20 Dec
Tomorrow
20 Dec - 21 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

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Our top choices for Santa Ana hotels

Living area
Hostal La Cigarra

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (55)
"Excelente "
Mexico
David
The price is S$32
includes taxes & fees
6 Jan - 7 Jan, 2026
Hostal La Cigarra
Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas, pool loungers
Casco View Apartments

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (55)
"Great stay, would recommend."
United States
Brooke
Casco View Apartments
View from room
Hotel República

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (182)
"Fantastic customer service"
United States
OLGA
Hotel República
Iron/ironing board, free WiFi, bed sheets
La Manzana by Wynwood House

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is S$139
includes taxes & fees
21 Dec - 22 Dec
La Manzana by Wynwood House
Front of property
ART CASCO The Hotel

ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.0 out of 10, (11)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
ART CASCO The Hotel
Exterior
Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A
2.0 star property
Santa Ana
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is S$208
includes taxes & fees
21 Dec - 22 Dec
Room-sofa Bed Stay Rooftop Pool & Gym, A
Outdoor spa tub
Hilton Garden Inn Panama City Downtown, Panama

Hilton Garden Inn Panama City Downtown, Panama

Hilton Garden Inn Panama City Downtown, Panama
3.5 star property
El Cangrejo, 3.4 km from Santa Ana
8.6 out of 10, Excellent, (1000)
"Stay was ok "
United States
suhail
The price is S$134
includes taxes & fees
26 Dec - 27 Dec
Hilton Garden Inn Panama City Downtown, Panama
Outdoor pool
Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina
3.0 star property
El Cangrejo, 3.8 km from Santa Ana
7.4 out of 10, Good, (268)
"Hotel staff and rooms were good , great location "
United States
Cornelly
The price is S$121
includes taxes & fees
21 Dec - 22 Dec
Ramada Panama Centro Via Argentina
Exterior
Crowne Plaza Panama by IHG

Crowne Plaza Panama by IHG

Crowne Plaza Panama by IHG
4.0 star property
Bella Vista, 3.2 km from Santa Ana
8.2 out of 10, Very good, (212)
"We chose the wrong hotel! We thought we were staying at the crowne plaza near the airport "
United States
Carmen
The price is S$153
includes taxes & fees
21 Dec - 22 Dec
Crowne Plaza Panama by IHG
Terrace/patio
Toscana Inn

Toscana Inn

Toscana Inn
3.5 star property
El Cangrejo, 3.7 km from Santa Ana
9.0 out of 10, Wonderful, (727)
"Friendly staff clean room’s walk able to shops"
United States
Noris
Toscana Inn
Terrace/patio
Tantalo Hotel

Tantalo Hotel

Tantalo Hotel
3.5 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (274)
"My favorite place in Casco Viejo. "
United States
Michael
Tantalo Hotel
In-room safe, desk, soundproofing, free WiFi
Hotel Acapulco

Hotel Acapulco

Hotel Acapulco
3.0 star property
Calidonia, 1.3 km from Santa Ana
7.8 out of 10, Good, (124)
"Excelente"
United States
Alejandro
The price is S$46
includes taxes & fees
18 Jan - 19 Jan, 2026
Hotel Acapulco
Restaurant
Gran Evenia Panama

Gran Evenia Panama

Gran Evenia Panama
4.5 star property
El Cangrejo, 3.8 km from Santa Ana
9.2 out of 10, Wonderful, (194)
"The property was conveniently located near shops, restaurants and casinos. The food at breakfast was good. Although the pancakes could be better. "
United States
Nicole
Gran Evenia Panama
Ecotours
Hotel Pension Corona

Hotel Pension Corona

Hotel Pension Corona
2.5 star property
Calidonia, 1.8 km from Santa Ana
7.8 out of 10, Good, (108)
"Great spot for the price "
United States
frank
Hotel Pension Corona
Reception
Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites
3.5 star property
El Cangrejo, 3.4 km from Santa Ana
8.8 out of 10, Excellent, (483)
"The buffet bar and great customer service. "
United States
Kayhiuska
Torres de Alba Hotel & Suites
Aerial view
Hotel Latino

Hotel Latino

Hotel Latino
3.0 star property
Calidonia, 1.8 km from Santa Ana
6.6 out of 10, (218)
"I was given room key attached to a piece of plastic. It was difficult to tell exactly which room number it was. I unlocked what I thought was my room and saw someone laying in bed unaware I opened the door slightly. I closed the door and asked a housekeeper which room I was in. She told me. When I entered my room the overpowering smell of moth balls was present. I found a room elsewhere and left after an hour. Staff was nice, I didn’t feel the need to go complain but I didn’t feel secure since...
United States
Paul Andrew
Hotel Latino
Lobby
Metro Hotel Panama

Metro Hotel Panama

Metro Hotel Panama
3.5 star property
El Cangrejo, 3.7 km from Santa Ana
7.8 out of 10, Good, (405)
"I like the lady who attended to us in the breakfast area."
United States
Sharon
Metro Hotel Panama
Exterior
Hotel Marparaiso

Hotel Marparaiso

Hotel Marparaiso
3.0 star property
Calidonia, 1.7 km from Santa Ana
7.8 out of 10, Good, (150)
"Pretty clear, some staff speak no English, AC was spot on, breakfast can improve, not fair from public transportation and the free shuttle service was a great aid in getting around to some places "
United States
EVELYN
The price is S$52
includes taxes & fees
21 Dec - 22 Dec
Hotel Marparaiso
Interior detail
Canova

Canova

Canova
3.0 star property
Calidonia, 1.4 km from Santa Ana
8.2 out of 10, Very good, (130)
"Very close place to everything. Very affordable. "
United States
Alex
The price is S$40
includes taxes & fees
20 Jan - 21 Jan, 2026
Canova
Outdoor pool, pool umbrellas, pool loungers
Holiday Inn Panama Canal by IHG

Holiday Inn Panama Canal by IHG

Holiday Inn Panama Canal by IHG
3.5 star property
6 km from Santa Ana
8.6 out of 10, Excellent, (443)
"The staff was so cordial and nice "
United States
Sonny
The price is S$159
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Panama Canal by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Punta Paitilla

Punta Paitilla is known for its abundant dining options, and you can plan a trip to Avenida Balboa and Multicentro Panama while you're in town.

Top Santa Ana Hotel Reviews

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

10/10 Excellent
"The staff were friendly and helpful. Check in was smooth, room was clean and had a nice view of the bay. The included breakfast buffet was great with a wide selection of foods. I would definitely recommend this hotel."
Simon 1-night trip
Posted 2 days ago
Plaza Paitilla Inn Hotel

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Cinta Costera and Avenida Balboa while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Based on our traveller data, Casco View Apartments is one of the top choices for your stay in Santa Ana. This condo is a short 8-minute walk from Avenida Balboa, and it offers an outdoor pool and in-room kitchens.
How many hotels can I expect to find in Santa Ana?
Expedia has 112 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighbourhood. Albrook Shopping Mall, Amador Theater and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.