Santa Ana Holidays

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  • Better together

    Save up to S$1,300 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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    Plan, book, and manage your trip all in one place

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
A waterfront cityscape with historic buildings and a prominent clock tower.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

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A cityscape with modern skyscrapers, including a distinctive twisting tower.

Bella Vista

1 out of top 10 points of interest in this area

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

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A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

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A bridge over a body of water with several boats.

San Francisco

1 out of top 10 points of interest in this area

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

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A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

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Top hotels in Santa Ana

Hotel Caracas - Casco Viejo

Hotel Caracas - Casco Viejo

Plaza De Santa Ana Panama City Provincia di Panama
Fully refundableReserve now, pay when you stay
S$55
8 Oct - 9 Oct
includes taxes & fees
8/10 Very good! (19 reviews)
"Good location but basic otherwise. Staff not overly helpful on the whole."

Reviewed on 27 Sept, 2026

Hotel Caracas - Casco Viejo
Casco View Apartments

Casco View Apartments

C. 16 Oeste Panama City Provincia de Panamá
S$149
1 Oct - 2 Oct
includes taxes & fees
9/10 Wonderful! (106 reviews)
"We really enjoyed our stay at Casco View. It was an easy walk into Casca Viejo and centrally located. The host uses a guesty app to provide room details, apartment codes, etc, so it was a really easy and smooth process to get checked in. The room itself was very clean and well appointed. We stayed ..."

Reviewed on 8 Sept, 2026

Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
S$193
27 Oct - 28 Oct
includes taxes & fees
Hotel Riu Plaza Panama
See all 1,792 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Ana holiday package cost?
From as little as . Yes, you read that correctly. Our Santa Ana holiday packages are an easy way to stretch your budget further. Combine your favourite hotels, flights and rental car and explore this destination your way.
How do I get a cheap travel package to Santa Ana?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Flights, hotels, activities and rental cars — we've got it all. Pick and choose the combination that best fits you and see your savings grow. We know a package deal is never a one-size-fits-all. That's why Expedia offers over 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Ana holiday.
Where should I stay in Santa Ana?
Most who travel to Santa Ana include both Miraflores Locks and Metropolitan Cathedral of Panama on their bucket lists. Why not go for a hotel right near these great attractions?
What are the top hotels in Santa Ana?
If it's your first time in Santa Ana, make a reservation at Hotel Riazor or Hotel Doral. Both hotels will make you feel at home and are favourites among lots of travellers.
How far in advance should I book my Santa Ana holiday?
While prices change from time to time, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to a year in advance. If circumstances have left you booking late, you might still be in luck. Low prices to Santa Ana sometimes occur only weeks before departure.
What does an Expedia Santa Ana travel package include?
That mostly depends on you. You can select from a range of Santa Ana packages, such as a rental car, flight and hotel. You can also book a hotel and a flight, or a rental car and a flight. Once you've made your booking, you can add on the fun stuff like tours and activities. Whatever your perfect Santa Ana break looks like, get set to save!
What should I know before booking a Santa Ana travel package?
Discover deals to suit your budget with an Expedia package. Hotels, airfares, rental cars — we've got everything you need to plan your getaway. You'll save big dollars just for bundling your bookings. Whether you're taking off on a ski trip or getting some sun on a warm beach, your ideal getaway is only clicks away.
Can I choose my airline with a Santa Ana Expedia holiday package?
Definitely. Expedia has more than 550 airline partners to pick from globally. With all that choice at your fingertips, finding the right carrier to get you to Santa Ana shouldn't be hard.
If I'm not able to travel, can I cancel my Santa Ana holiday package?
We totally get it — life can throw you the odd curveball. If you've booked a Santa Ana holiday package and have to amend or cancel it, we're here to help. It's always worth visiting our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary at no cost. If it's been longer than 24 hours, your hotel, airline or car rental company may charge a fee.

Stay near popular Santa Ana attractions

El Machetazo Santa Ana

You can browse for the perfect souvenirs at El Machetazo Santa Ana during your visit to Panama City. Amble around the area's parks or visit its shops.
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Things to do

Picture 3 for Activity Panama City: All-Inclusive Catamaran Cruise to Taboga Island

Panama City: All-Inclusive Catamaran Cruise to Taboga Island

S$126
per adult
94% of travellers recommend
Panama City: All-Inclusive Catamaran Cruise to Taboga Island
Panama Canal: The Most Complete Monkey Island Experience

Panama Canal: The Most Complete Wildlife Experience

S$61
per adult
98% of travellers recommend
Panama Canal: The Most Complete Wildlife Experience
Panama: Monkey and Sloth Jungle Habitat Panama Tour

Panama: Monkey and Sloth Jungle Habitat Panama Tour

S$77
per adult
100% of travellers recommend
Panama: Monkey and Sloth Jungle Habitat Panama Tour
See all activities in Panama City

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.