Hotels in Santa Ana

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Check prices for these dates

Tonight
25 Dec - 26 Dec
Tomorrow
26 Dec - 27 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

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Our top choices for Santa Ana hotels

Living area
Hostal La Cigarra

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (55)
"Excelente "
Mexico
David
The price is S$32
includes taxes & fees
25 Jan - 26 Jan, 2026
Hostal La Cigarra
Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas, pool loungers
Casco View Apartments

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (56)
"We live this property and stay here whenever we are in town."
United States
chris
Casco View Apartments
View from room
Hotel República

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (182)
"Fantastic customer service"
United States
OLGA
Hotel República
Front of property
ART CASCO The Hotel

ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.0 out of 10, (11)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
ART CASCO The Hotel
Iron/ironing board, free WiFi, bed sheets
La Manzana by Wynwood House

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is S$137
includes taxes & fees
4 Jan - 5 Jan, 2026
La Manzana by Wynwood House
Exterior
Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A
2.0 star property
Santa Ana
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is S$205
includes taxes & fees
14 Jan - 15 Jan, 2026
Room-sofa Bed Stay Rooftop Pool & Gym, A
Outdoor pool
Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina
3.0 star property
El Cangrejo, 3.8 km from Santa Ana
7.4 out of 10, Good, (270)
"Hotel staff and rooms were good , great location "
United States
Cornelly
The price is S$120
includes taxes & fees
4 Jan - 5 Jan, 2026
Ramada Panama Centro Via Argentina
Outdoor pool, pool umbrellas, pool loungers
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
4.0 star property
21.1 km from Santa Ana
8.4 out of 10, Very good, (2331)
"Great breakfast was included and the airport shuttle was conveniently located "
United States
Adrienne
The price is S$155
includes taxes & fees
15 Jan - 16 Jan, 2026
Crowne Plaza Panama Airport by IHG
Exterior
ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport
2.5 star property
20.5 km from Santa Ana
9.0 out of 10, Wonderful, (39)
"It was a cool unique antique place that had modern touches. The staff was very friendly and helpful. Will definitely stay again. "
United States
Clarissa
The price is S$200
includes taxes & fees
5 Jan - 6 Jan, 2026
ORHO HOTEL BOUTIQUE PANAMA Airport
Outdoor pool, open 7:00 AM to 10:30 PM, free pool cabanas
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
19.8 km from Santa Ana
8.6 out of 10, Excellent, (1847)
"Better than expected: Location, transportation to and from airport, pool area tropical and comfortable. "
United States
Marty
The price is S$177
includes taxes & fees
26 Dec - 27 Dec
Riande Aeropuerto Hotel & Casino
Food and drink
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
14.6 km from Santa Ana
8.8 out of 10, Excellent, (1002)
"The hotel is conveniently close to the airport and shopping centres. "
United States
Samantha
The price is S$155
includes taxes & fees
8 Jan - 9 Jan, 2026
Courtyard by Marriott Panama Metromall
View from property
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz, 12.7 km from Santa Ana
9.6 out of 10, Exceptional, (644)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is S$317
includes taxes & fees
25 Jan - 26 Jan, 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este, 10.2 km from Santa Ana
9.4 out of 10, Exceptional, (167)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
The price is S$176
includes taxes & fees
26 Dec - 27 Dec
Arcadia Condo Suites
Outdoor pool, pool umbrellas, pool loungers
The Westin Panama

The Westin Panama

The Westin Panama
4.0 star property
Costa del Este, 9.4 km from Santa Ana
9.0 out of 10, Wonderful, (311)
"Great hotel and services"
United States
Pedro
The price is S$302
includes taxes & fees
24 Jan - 25 Jan, 2026
The Westin Panama
Daily buffet breakfast (PAB 21 per person)
Sheraton Grand Panama

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco, 5.7 km from Santa Ana
8.6 out of 10, Excellent, (996)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is S$189
includes taxes & fees
9 Jan - 10 Jan, 2026
Sheraton Grand Panama
Exterior
Aloft Panama

Aloft Panama

Aloft Panama
3.5 star property
San Francisco, 5.7 km from Santa Ana
8.8 out of 10, Excellent, (896)
"Great staff..warm and welcoming...enjoyed our stay!"
United States
Alystra Marissa Arjoon
The price is S$168
includes taxes & fees
2 Jan - 3 Jan, 2026
Aloft Panama
4 outdoor pools, free pool cabanas, pool umbrellas
JW Marriott Panama

JW Marriott Panama

JW Marriott Panama
5.0 star property
Punta Pacifica, 4.3 km from Santa Ana
9.0 out of 10, Wonderful, (1001)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is S$450
includes taxes & fees
9 Jan - 10 Jan, 2026
JW Marriott Panama
Breakfast, lunch, dinner served; international cuisine
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco, 5.1 km from Santa Ana
9.6 out of 10, Exceptional, (1125)
"The hotel is in a great location in Panama. Great amenities excellent breakfast."
United States
Maria
The price is S$138
includes taxes & fees
2 Jan - 3 Jan, 2026
Ramada Plaza by Wyndham Panama Punta Pacifica
Outdoor pool, open 6:00 AM to 11:00 PM, pool umbrellas, pool loungers
Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City
4.0 star property
Punta Paitilla, 4 km from Santa Ana
9.0 out of 10, Wonderful, (542)
"It's location is close to everything. "
United States
Sharon
The price is S$239
includes taxes & fees
8 Jan - 9 Jan, 2026
Residence Inn by Marriott Panama City
Terrace/patio
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2136)
"Great location of the hotel with a lovely breakfast and friendly staff"
United States
fouad
The price is S$152
includes taxes & fees
16 Jan - 17 Jan, 2026
Plaza Paitilla Inn Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Felipe

While visiting San Felipe, you might make a stop by sights like Interoceanic Canal Museum and National Theater.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Top Santa Ana Hotel Reviews

Decapolis Hotel Panama City

Decapolis Hotel Panama City

10/10 Excellent
"Good"
Mario 2-night trip
Posted 2 days ago
Decapolis Hotel Panama City

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Cinta Costera and Avenida Balboa while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Based on our traveller data, Casco View Apartments is one of the top choices for your stay in Santa Ana. This condo is a short 8-minute walk from Avenida Balboa, and it offers an outdoor pool and in-room kitchens.
How many hotels can I expect to find in Santa Ana?
Expedia has 111 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighbourhood. Albrook Shopping Mall, Amador Theater and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.