What's it like in Santa Ana?

Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Avenida Balboa and El Machetazo Santa Ana while you're in the neighbourhood.

Where is the best hotel for a stay in Santa Ana?

Based on our traveller data, Hotel Caracas - Casco Viejo is one of the top choices for your stay in Santa Ana. This hotel is a short 7-minute walk from Avenida Balboa, and it offers a restaurant and a bar. Another good choice for your stay in the area is Casco View Life Residences .

How many hotels can I expect to find in Santa Ana?

Expedia has 135 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.

If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.

What is there to do in this Panama City neighbourhood?

If you're looking forward to a day of shopping in Santa Ana, consider El Machetazo Santa Ana or Avenida Balboa, and pick out the perfect souvenir. When you're sightseeing in Panama City, Albrook Shopping Mall and Avenida Central are also worth a stop.

Top 10 Santa Ana Hotels of 2026

A gazebo with columns, a large tree with hanging roots, and a building in the background.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Santa Ana hotels

A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.

1. Casco View Life Residences

Santa Ana

Ruben

includes taxes & fees

1 Oct - 2 Oct

A hotel corridor with wooden doors, a central white reception desk, and a staircase leading to an upper level.

2. Hotel Caracas - Casco Viejo

Santa Ana

Keith

includes taxes & fees

8 Oct - 9 Oct

A restaurant with a long counter, chairs, and tables. There are plants and lights decorating the space.

3. Hostal La Cigarra

Santa Ana

Mark

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a large bed, a window with curtains, a city view, and a lamp.

4. Hotel República

Santa Ana

Danilo

includes taxes & fees

31 Oct - 1 Nov

A hotel entrance with a green facade and a metal fence.

5. ART CASCO The Hotel

Santa Ana

Eldris

includes taxes & fees

8 Oct - 9 Oct

A modern hotel room with a large bed, a sofa, a TV, and a view of the city.

6. La Manzana Barrio Vivo by Wynwood

Santa Ana

Javier Alberto Lindauer

includes taxes & fees

3 Oct - 4 Oct

A bar area with a curved counter, multiple seating options, and a variety of bottles and glasses on display.

7. Hotel Riazor

Santa Ana

Del

includes taxes & fees

1 Oct - 2 Oct

8. Room-sofa Bed Stay Rooftop Pool & Gym, A

Santa Ana

Cristian Camilo Betancur

includes taxes & fees

31 Oct - 1 Nov

A modern lobby with a chandelier, seating area, reception desk, and a staircase.

9. The Executive Hotel

Campo Alegre, 3.2 km from Santa Ana

Sandra

includes taxes & fees

21 Oct - 22 Oct

A spacious living room with blue sofas, a marble coffee table, and framed pictures on the walls.

10. Hotel Magnolia Boutique

San Felipe, 0.7 km from Santa Ana

Boris

includes taxes & fees

4 Oct - 5 Oct

A hotel named PRINCIPE with a modern facade and large glass windows.

11. Principe Hotel and Suites

El Cangrejo, 3.9 km from Santa Ana

Dayami

includes taxes & fees

11 Oct - 12 Oct

A rooftop pool with sun loungers and a city skyline in the background.

12. Waymore Hotel Spa & Casino

El Cangrejo, 3.5 km from Santa Ana

kevin

includes taxes & fees

24 Oct - 25 Oct

A restaurant with booths, a neon-lit red wall, hanging plants, and pendant lights.

13. Hotel Mio Panama

Campo Alegre, 3.5 km from Santa Ana

Shari

includes taxes & fees

16 Oct - 17 Oct

A rooftop bar with a city skyline view, outdoor seating, and a bar area with bottles and glasses.

14. Tantalo Hotel

San Felipe, 0.7 km from Santa Ana

Cassondra

includes taxes & fees

6 Oct - 7 Oct

A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.

15. Hotel Riu Plaza Panama

Campo Alegre, 3.6 km from Santa Ana

Sandrelly

includes taxes & fees

27 Oct - 28 Oct

A modern lobby with seating areas, large windows, and a visible exit sign.

16. Holiday Inn Panama Distrito Financiero by IHG

Campo Alegre, 3.7 km from Santa Ana

Douglas R Ng

includes taxes & fees

6 Oct - 7 Oct

A balcony with wicker chairs and a view of the cityscape.

17. Ramada Plaza by Wyndham Panama Punta Pacifica

San Francisco, 5.1 km from Santa Ana

Maria

includes taxes & fees

2 Oct - 3 Oct

A hotel room with a bed, a desk with a computer, a chair, a mirror, and a staircase.

18. Hotel Bardot Boutique

San Felipe, 1.1 km from Santa Ana

Gary

includes taxes & fees

4 Oct - 5 Oct

A hotel entrance with a covered walkway, large windows, and a well-maintained garden area.

19. Hotel Milan

El Cangrejo, 3.6 km from Santa Ana

Arshak Andrew

includes taxes & fees

8 Oct - 9 Oct

A covered outdoor seating area with a view of a city skyline and water.

20. Plaza Paitilla Inn Hotel

Punta Paitilla, 3.4 km from Santa Ana

Jennifer

includes taxes & fees

26 Oct - 27 Oct

View all properties

Compare popular hotels in Santa Ana

Property	Property class	Guest rating
Casco View Life Residences	4.0 star property	9.0 Wonderful 106 reviews	View
Hotel Caracas - Casco Viejo	3.0 star property	8.0 Very good 19 reviews	View
Hostal La Cigarra	2.0 star property	7.6 Good 75 reviews	View
La Manzana Barrio Vivo by Wynwood	3.0 star property	7.6 Good 19 reviews	View
Hotel República	2.0 star property	6.8 197 reviews	View

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

A coastal cityscape with a prominent church tower, a river, and distant mountains.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

See properties

A harbor with several boats docked in the foreground and a city skyline in the background.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

See properties

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

See properties

A bridge over a body of water with several boats.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

See properties

A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

See properties

Top Santa Ana Hotel Reviews

Crowne Plaza Panama Airport by IHG

10/10 Excellent

"Super convenient location"

Central Hotel Panama Casco Viejo

10/10 Excellent

"Beautiful hotel, amazing food, and even better staff. Everyone went above and beyond to genuinely make us feel welcome, and you could tell they took a lot of pride in the hotel and their roles. A special thank you to Jose Luis, Victor, Felix, and the rest of the restaurant staff. They were excellent and a big part of what made our stay so enjoyable. We will definitely be staying at Central Hotel again when we’re back in Panama next year. Highly recommend!"

Casco View Apartments

10/10 Excellent

"We really enjoyed our stay at Casco View. It was an easy walk into Casca Viejo and centrally located. The host uses a guesty app to provide room details, apartment codes, etc, so it was a really easy and smooth process to get checked in. The room itself was very clean and well appointed. We stayed on the 6th floor, which is also the floor with the pool, which offered really great views of the surrounding areas. Honestly, the hotel is a very sleek and modern building, surrounded by some rougher buildings. Don't let that deter you though - we felt very safe coming and going, even late at night, and it's only a block or so Santa Ana square. It was a great stay and we'd definitely consider it again next time we stay in Casco Viejo area."

Hotels in Santa Ana

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Santa Ana hotels

1. Casco View Life Residences

2. Hotel Caracas - Casco Viejo

3. Hostal La Cigarra

4. Hotel República

5. ART CASCO The Hotel

6. La Manzana Barrio Vivo by Wynwood

7. Hotel Riazor

8. Room-sofa Bed Stay Rooftop Pool & Gym, A

9. The Executive Hotel

10. Hotel Magnolia Boutique

11. Principe Hotel and Suites

12. Waymore Hotel Spa & Casino

13. Hotel Mio Panama

14. Tantalo Hotel

15. Hotel Riu Plaza Panama

16. Holiday Inn Panama Distrito Financiero by IHG

17. Ramada Plaza by Wyndham Panama Punta Pacifica

18. Hotel Bardot Boutique

19. Hotel Milan

20. Plaza Paitilla Inn Hotel

Compare popular hotels in Santa Ana

Where to stay in Santa Ana

Casco Viejo

Bella Vista

El Cangrejo

San Francisco

San Felipe

Top Santa Ana Hotel Reviews

Crowne Plaza Panama Airport by IHG

Frequently asked questions