Guadalupe District

Santa Fe

A great evening visiting the art galleries topped with a stop at a brew pub draft in the Santa Fe Railroad Artisan Museum district.
A great evening visiting the art galleries topped with a stop at a brew pub draft in the Santa Fe Railroad Artisan Museum district.
The church with a moonlit backdrop. #GoldenHour
The Santa Fe Railyard is social place in the center of town where you can grab a bite to eat, access bike and walking trails, and on the weekends explore a great farmer's market. #newmexico #santafe
This is a purely residential area with nothing to offer but great people and amazing Old Santa Fe architecture. It's one of those "only locals know" streets. #CeliaLuzPhotography #BW #architecture #SantaFe #NewMexico #statue #streetart #local #travel #angel

Top hotels in Guadalupe District

Guadalupe Inn

Guadalupe Inn

2 out of 5
604 Agua Fria St. Santa Fe NM
The price is S$146 per night from 1 Mar to 2 Mar
S$146
1 Mar - 2 Mar
includes taxes & fees
Stay at this hotel in Santa Fe. Enjoy free Wi-Fi, parking (surcharge) and a business centre. Our guests praise the helpful staff in their reviews. Popular attractions ...
9.2/10 Wonderful! (1,007 reviews)
The room has great charm and decor. The staff is friendly. The location is very quiet.

Reviewed on 23 Feb, 2026

Guadalupe Inn
La Fonda on the Plaza

La Fonda on the Plaza

4 out of 5
100 E San Francisco St Santa Fe NM
The price is S$274 per night from 8 Mar to 9 Mar
S$274
8 Mar - 9 Mar
includes taxes & fees
Stay at this historic hotel in Santa Fe. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Our guests praise the restaurant and the helpful staff in their ...
9.2/10 Wonderful! (1,101 reviews)
Absolutely fabulous and Expedia saved a ton

Reviewed on 23 Feb, 2026

La Fonda on the Plaza
Drury Plaza Hotel in Santa Fe

Drury Plaza Hotel in Santa Fe

3.5 out of 5
828 Paseo de Peralta Santa Fe NM
The price is S$216 per night from 4 Mar to 5 Mar
S$216
4 Mar - 5 Mar
includes taxes & fees
Stay at this business-friendly hotel in Santa Fe. Enjoy free breakfast, free Wi-Fi and room service. Our guests praise the breakfast and the pool in their reviews. ...
9.6/10 Exceptional! (1,453 reviews)
Beautiful place. Friendly staff. Highly recommend.

Reviewed on 26 Feb, 2026

Drury Plaza Hotel in Santa Fe
Inn and Spa at Loretto

Inn and Spa at Loretto

4 out of 5
211 Old Santa Fe Trail Santa Fe NM
The price is S$348 per night from 15 Mar to 16 Mar
S$348
15 Mar - 16 Mar
includes taxes & fees
Stay at this business-friendly hotel in Santa Fe. Enjoy breakfast (surcharge), a fitness centre and on-site spa services. Our guests praise the restaurant and ...
9/10 Wonderful! (1,002 reviews)
The Hotel was amazing - the rooms, staff and amenities were on point. Plenty of nice shops in the hotel and right next door to the Loretto Chapel.

Reviewed on 16 Feb, 2026

Inn and Spa at Loretto
El Sendero Inn, an Ascend Collection Hotel

El Sendero Inn, an Ascend Collection Hotel

2.5 out of 5
311 Old Santa Fe Trail Santa Fe NM
The price is S$137 per night from 1 Mar to 2 Mar
S$137
1 Mar - 2 Mar
includes taxes & fees
Stay at this business-friendly hotel in Santa Fe. Enjoy free Wi-Fi, an outdoor pool and parking (surcharge). Our guests praise the helpful staff and the convenient ...
9/10 Wonderful! (1,598 reviews)
Clean, hassle-free checkin /out. LOCATION is primo!

Reviewed on 26 Feb, 2026

El Sendero Inn, an Ascend Collection Hotel
The Sage Hotel

The Sage Hotel

3 out of 5
725 Cerrillos Rd Santa Fe NM
The price is S$105 per night from 28 Feb to 1 Mar
S$105
28 Feb - 1 Mar
includes taxes & fees
Stay at this business-friendly hotel in Santa Fe. Enjoy an outdoor pool, room service and a 24-hour fitness centre. Our guests praise the breakfast and the restaurant ...
8/10 Very Good! (2,225 reviews)
Every staff member was very professional, personable, and knowledgeable.

Reviewed on 27 Feb, 2026

The Sage Hotel
See all 1,670 properties in Guadalupe District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

The Annual Holiday Sale

Members save up to 40% on hotels. Plan this year’s big trip and save.
Book now

Other neighbourhoods around Guadalupe District

Default Image

West Manhattan

West Manhattan might not have many top sights, but Santa Fe Railyard and Santuario De Nuestra Senora de Guadalupe are two attractions nearby that you can check out.

West Manhattan
A great evening visiting the art galleries topped with a stop at a brew pub draft in the Santa Fe Railroad Artisan Museum district.

Railyard Arts District

Art galleries, shopping and spas highlight some of the noteworthy features of Railyard Arts District. Make a stop by Santa Fe Railyard or Santa Fe Farmers Market while you're exploring the neighbourhood.

Railyard Arts District
New Mexico Museum of Art which includes a statue or sculpture and art

Downtown Santa Fe

4.5/5(14 area reviews)

Visitors to Downtown Santa Fe rave about its fascinating museums, popular shops and acclaimed art galleries. You might also want to make some time to see Santuario De Nuestra Senora de Guadalupe or Lensic Performing Arts Center while you're exploring the neighbourhood.

Downtown Santa Fe
Delicious vegan and vegetarian options for breakfast and lunch. I had the vegan skillet with green chili and cucumber water #santafe #eats #summer #weekendgetaway

West Guadaloupe

While West Guadaloupe may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Harrell House of Natural Oddities and Bug Museum and Santuario De Nuestra Senora de Guadalupe.

West Guadaloupe
My favorite juice/smoothie/breakfast place in Santa Fe. They also sell general goods and offer lunch. #places #eat #generalgoods #store #goods #flowers #coffee #restaurants #santafe #travel #breakfast #lunch #smoothies #juices #healthy

Don Diego

If you're spending some time in Don Diego, Santa Fe Climbing Gym and Santa Fe Symphony Orchestra and Chorus are top sights worth seeing.

Don Diego
Default Image

Casa Solana

When in Casa Solana, you can plan a visit to Harrell House of Natural Oddities and Bug Museum and Santuario De Nuestra Senora de Guadalupe, some noteworthy sights in the nearby area.

Casa Solana

Guadalupe District