⭐ Top 10 Hotels Near Sikeston Depot Museum for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Sikeston Depot Museum hotels

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

1. Fairfield Inn & Suites by Marriott Sikeston

2.4 km from Sikeston Depot Museum

Allen

S$146

includes taxes & fees

1 Oct - 2 Oct

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

2. TownePlace Suites by Marriott Sikeston

2.3 km from Sikeston Depot Museum

Stacy

S$145

includes taxes & fees

4 Oct - 5 Oct

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

3. Hampton Inn Sikeston

2.3 km from Sikeston Depot Museum

John

S$147

includes taxes & fees

11 Oct - 12 Oct

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A kitchenette with a coffee machine, a kettle, and storage shelves.

A buffet with various food items, including omelets and baked goods, served in metal containers.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

4. Holiday Inn Express & Suites Sikeston Southwest by IHG

2.1 km from Sikeston Depot Museum

michael

S$138

includes taxes & fees

25 Oct - 26 Oct

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

5. Drury Inn & Suites Sikeston, MO

5.1 km from Sikeston Depot Museum

Scott

S$157

includes taxes & fees

29 Sept - 30 Sept

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

6. Best Western Plus Sikeston I-55

5.4 km from Sikeston Depot Museum

Shelley

S$127

includes taxes & fees

27 Sept - 28 Sept

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

A Travel Inn and Suites building with a prominent illuminated sign, a brick facade, and a parking lot.

7. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

5 km from Sikeston Depot Museum

Sharika West

S$94

includes taxes & fees

27 Sept - 28 Sept

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A living room with two sofas, a coffee table, a TV, and a cabinet.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

8. Comfort Inn & Suites Sikeston I-55

4.9 km from Sikeston Depot Museum

Starlette

S$130

includes taxes & fees

20 Oct - 21 Oct

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

9. Days Inn and Suites by Wyndham Sikeston

5.4 km from Sikeston Depot Museum

David

S$97

includes taxes & fees

27 Sept - 28 Sept

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

10. Super 8 by Wyndham Sikeston/Miner Area

4.7 km from Sikeston Depot Museum

William

S$83

includes taxes & fees

1 Oct - 2 Oct

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.

A reception area with a counter, a coffee machine, and seating.

11. Country Yard Inn and Suite

5.5 km from Sikeston Depot Museum

William

S$87

includes taxes & fees

16 Oct - 17 Oct

View all properties

Compare popular hotels close to Sikeston Depot Museum

Property	Property class	Guest rating
Fairfield Inn & Suites by Marriott Sikeston	9.4 Exceptional 112 reviews	View
TownePlace Suites by Marriott Sikeston	9.4 Exceptional 26 reviews	View
Hampton Inn Sikeston	9.0 Wonderful 624 reviews	View
Holiday Inn Express & Suites Sikeston Southwest by IHG	8.8 Excellent 508 reviews	View
Drury Inn & Suites Sikeston, MO	9.6 Exceptional 1,001 reviews	View

Top Sikeston Depot Museum Hotel Reviews

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Clean room and perfect stay. We have come to consistently appreciate Drury brand for a quality stay. We would definitely recommend this location for clean comfortable accommodations."

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"The hall ways smelled so good but we did get dirty blankets . They have many restaurants and stores options really closed by so if you have children it is a great spot to stop specifically since is just in the entry or exit of the hwy ."

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"."

Hampton Inn Sikeston

10/10 Excellent

"Staff was great"

Super 8 by Wyndham Charleston/Sikeston East MO

10/10 Excellent

"Súper affordable pricing, and the property was clean and comfortable! Complimentary breakfast was a plus!"

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"This was a very good value. It has been the best hotel I've stayed at in awhile."

TownePlace Suites by Marriott Sikeston

10/10 Excellent

"My overall experience was amazing from the time I checked in until I left. The staff were super pleasant and incredible. My room was clean and spacious. I never been in an extended stay room before. I definitely will be booking a suite like this one again."

Hampton Inn By Hilton Dexter

8/10 Good

"Very nice hotel - our favorite when we visit the grandkids! Our only issue this time was with housekeeping. We arrived Friday afternoon, asked that our room be serviced on Sunday, (they only do it every other day), and it was not done. Also, in the shower were the usual shampoo and shower gel, but instead of conditioner, the 3rd dispenser was body lotion! I asked if the lotion could be replaced with conditioner - didn’t happen. Disappointed!"

The Riverstone Hotel Charleston-Sikeston

8/10 Good

"Overall it was excellant, other then the toilet running constantly... Pool could have been cleaner, considering the heat-wave they were having............."

Other attractions near Sikeston Depot Museum

Central Park

7.2/10 (56 reviews)

Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this family-friendly area, you can savour the top-notch restaurants.

See properties

City of Miner Convention Center

Learn about the events happening in City of Miner Convention Center during your trip to Miner. While in this relaxing area, you can savour the top-notch restaurants.

See properties

Front Street Studio & Art Gallery

8.6/10 (15 reviews)

You can spend time browsing the exhibits at Front Street Studio & Art Gallery during your travels in Blodgett. While in this relaxing area, you can savour the top-notch restaurants.

See properties

Hunter-Dawson State Historic Site

7.6/10 (13 reviews)

You can browse the exhibits at Hunter-Dawson State Historic Site, a museum with a story of its own, during your trip to New Madrid. Amble around the area's parks or experience its museums.

See properties

River Ridge Winery

8.4/10 (15 reviews)

You can enjoy a tasting or tour at River Ridge Winery during your travels to New Madrid. Amble around the area's parks or experience its museums.

See properties

New Madrid Historical Museum

8.2/10 (36 reviews)

You can study the exhibits at New Madrid Historical Museum, a museum with a storied past, during your travels to New Madrid. Amble around the area's parks or experience its museums.

See properties

Dexter Welcome Center Depot and Museum

7.6/10 (12 reviews)

You can study the exhibits at Dexter Welcome Center Depot and Museum, a museum with a story of its own, during your holiday in Dexter. While in this family-friendly area, you can enjoy the restaurants.

See properties

The Heritage House

8.4/10 (7 reviews)

Learn about the local history of Dexter with a stop at The Heritage House. While in this family-friendly area, you can enjoy the restaurants.

See properties

Frequently asked questions

What's the area like around Sikeston Depot Museum?

Sikeston Depot Museum is located in a welcoming area of Sikeston known for its array of dining options. If you're looking for a convenient place to stay, take a look at the 5 hotels and other accommodation options you'll find within a mile.

What's the best place to stay near Sikeston Depot Museum?

Drury Inn & Suites Sikeston, MO is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an outdoor pool. It's located 3.2 mi (5.1 km) from Sikeston Depot Museum. Other good choices within 5 miles include Hampton Inn Sikeston and Days Inn and Suites by Wyndham Sikeston.

How many hotels will I find close to Sikeston Depot Museum?

Expedia has 5 hotels and other accommodation options within a mile from Sikeston Depot Museum.

If I need to cancel the hotel reservation for my stay near Sikeston Depot Museum, will I receive a refund?

Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and get a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best options available near Sikeston Depot Museum.

Hotels near Sikeston Depot Museum

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Sikeston Depot Museum hotels

1. Fairfield Inn & Suites by Marriott Sikeston

2. TownePlace Suites by Marriott Sikeston

3. Hampton Inn Sikeston

4. Holiday Inn Express & Suites Sikeston Southwest by IHG

5. Drury Inn & Suites Sikeston, MO

6. Best Western Plus Sikeston I-55

7. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8. Comfort Inn & Suites Sikeston I-55

9. Days Inn and Suites by Wyndham Sikeston

10. Super 8 by Wyndham Sikeston/Miner Area

11. Country Yard Inn and Suite

Compare popular hotels close to Sikeston Depot Museum

Top Sikeston Depot Museum Hotel Reviews

Drury Inn & Suites Sikeston, MO

Super 8 by Wyndham Sikeston/Miner Area

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Hampton Inn Sikeston

Super 8 by Wyndham Charleston/Sikeston East MO

Days Inn and Suites by Wyndham Sikeston

TownePlace Suites by Marriott Sikeston

Hampton Inn By Hilton Dexter

The Riverstone Hotel Charleston-Sikeston

Other attractions near Sikeston Depot Museum

Central Park

City of Miner Convention Center

Front Street Studio & Art Gallery

Hunter-Dawson State Historic Site

River Ridge Winery

New Madrid Historical Museum

Dexter Welcome Center Depot and Museum

The Heritage House

Frequently asked questions