South Carolina Midlands Hotels from S$81

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for South Carolina Midlands hotels

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
2.5 star property
Florence
8.6 out of 10, Excellent, (1,001 reviews)
"The stay was great"
United States
Dianne
The price is S$178
includes taxes & fees
3 May - 4 May
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
3.0 star property
Santee
9.8 out of 10, Exceptional, (1,002 reviews)
"Excellent hotel, clean rooms, great breakfast "
United States
Roberta
The price is S$189
includes taxes & fees
26 Apr - 27 Apr
Fairfield Inn & Suites by Marriott Santee

Hampton Inn & Suites Lexington Columbia

Hampton Inn & Suites Lexington Columbia
2.5 star property
Lexington
9.8 out of 10, Exceptional, (636 reviews)
"Wonderful stay! Room was very clean and staff was super friendly and welcoming. "
United States
Laura
The price is S$178
includes taxes & fees
3 May - 4 May
Hampton Inn & Suites Lexington Columbia

Lexington Expo Hotel by IHG

Lexington Expo Hotel by IHG
3.0 star property
Lexington
9.0 out of 10, Wonderful, (1,001 reviews)
"clean and staff very nice"
United States
Denard
The price is S$155
includes taxes & fees
19 Apr - 20 Apr
Lexington Expo Hotel by IHG

Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (791 reviews)
"Great stay!"
United States
Preston
The price is S$160
includes taxes & fees
4 May - 5 May
Tru By Hilton Santee

Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1,001 reviews)
"Very clean & the breakfast staff was very courteous."
United States
Helen
The price is S$177
includes taxes & fees
10 May - 11 May
Hampton Inn Santee-I-95

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence
2.0 star property
Florence
8.6 out of 10, Excellent, (2,618 reviews)
"Very comfortable room and the hotel was close to the Interstate and many good trestaurants."
United States
Charles
The price is S$95
includes taxes & fees
26 Apr - 27 Apr
Howard Johnson by Wyndham Florence

Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1,000 reviews)
"Great breakfast bar - beautiful location in golf course and easy parking. "
United States
Nicole
The price is S$168
includes taxes & fees
3 May - 4 May
Best Western Plus Santee Inn

Inn on the Square, an Ascend Collection Hotel

Inn on the Square, an Ascend Collection Hotel
3.0 star property
Uptown Greenwood
9.2 out of 10, Wonderful, (730 reviews)
"Near to historic district. "
United States
Sandra
The price is S$167
includes taxes & fees
10 May - 11 May
Inn on the Square, an Ascend Collection Hotel

Holiday Inn Express & Suites Latta by IHG

Holiday Inn Express & Suites Latta by IHG
2.5 star property
Latta
9.6 out of 10, Exceptional, (572 reviews)
"Great visit to this site...convenient to food, gas, and the staff was so pleasant. Breakfast was very good and I would not hesitate to stay there again"
United States
Cheryl
The price is S$158
includes taxes & fees
3 May - 4 May
Holiday Inn Express & Suites Latta by IHG

Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area
2.5 star property
Florence
9.0 out of 10, Wonderful, (1,260 reviews)
"Clean room, good breakfast...very nice overnight stay."
United States
Gerry
The price is S$141
includes taxes & fees
3 May - 4 May
Comfort Inn & Suites Florence Center Area

Best Western Executive Inn

Best Western Executive Inn
2.5 star property
Latta
8.2 out of 10, Very good, (980 reviews)
"The staff at check in and the staff at check out was wonderful "
United States
Jackieann
The price is S$147
includes taxes & fees
11 May - 12 May
Best Western Executive Inn

Hampton Inn & Suites Fort Mill

Hampton Inn & Suites Fort Mill
2.5 star property
Fort Mill
9.2 out of 10, Wonderful, (863 reviews)
"Room was exceptionally clean. We will definitely stay here again!"
United States
Cynthia
The price is S$158
includes taxes & fees
3 May - 4 May
Hampton Inn & Suites Fort Mill

Springhill Suites by Marriott Columbia near Fort Jackson

Springhill Suites by Marriott Columbia near Fort Jackson
2.0 star property
Columbia
9.4 out of 10, Exceptional, (662 reviews)
"Property was excellent, breakfast was just okay"
United States
JAMES
The price is S$156
includes taxes & fees
3 May - 4 May
Springhill Suites by Marriott Columbia near Fort Jackson

Hampton Inn & Suites Florence-North-I-95

Hampton Inn & Suites Florence-North-I-95
2.5 star property
Florence
9.0 out of 10, Wonderful, (893 reviews)
"Busy hotel. Nice rooms awesome free breakfast "
United States
Ken
The price is S$173
includes taxes & fees
27 Apr - 28 Apr
Hampton Inn & Suites Florence-North-I-95

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
7.8 out of 10, Good, (1,443 reviews)
"Location was great for a one night stay over "
Canada
Silvana
The price is S$113
includes taxes & fees
12 Apr - 13 Apr
Baymont by Wyndham Santee

Tru by Hilton Orangeburg

Tru by Hilton Orangeburg
2.5 star property
Orangeburg
9.2 out of 10, Wonderful, (1,008 reviews)
"Great stay! "
Canada
Julie
The price is S$161
includes taxes & fees
28 Apr - 29 Apr
Tru by Hilton Orangeburg

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown
3.0 star property
Florence
9.0 out of 10, Wonderful, (1,004 reviews)
"Mostly a pleasant day, there must be a reason that microwaves are not in the rooms but having at least 1 on the floor with rooms for physical challenges would nice. Warming up food in the kitchen microwave and you are onthe 5th floor means a trek."
United States
Tynell
The price is S$174
includes taxes & fees
30 Apr - 1 May
Hyatt Place Florence Downtown

Holiday Inn Express & Suites Newberry by IHG

Holiday Inn Express & Suites Newberry by IHG
2.5 star property
Newberry
9.0 out of 10, Wonderful, (670 reviews)
"Clean room, comfy bed and great breakfast"
United States
Ronald
The price is S$139
includes taxes & fees
9 May - 10 May
Holiday Inn Express & Suites Newberry by IHG

SpringHill Suites by Marriott Orangeburg

SpringHill Suites by Marriott Orangeburg
2.5 star property
Orangeburg
8.8 out of 10, Excellent, (736 reviews)
"Fabulous hotel you will enjoy you stay and love the staff "
United States
Cordasha
The price is S$185
includes taxes & fees
22 Apr - 23 Apr
SpringHill Suites by Marriott Orangeburg
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Holiday Rentals in South Carolina Midlands

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Southeastern United States attractions

Learn more about South Carolina Midlands

With Revolutionary War sites, a charming capital city and lots of kayaking opportunities, this southern region is sure to delight.

Top South Carolina Midlands Hotel Reviews

More cheap stays in South Carolina Midlands

Hotels in South Carolina Midlands with star rating

Explore a world of travel with Expedia