Photo by Southernmost Illinois Tourism Bureau
Find Luxury Hotels in Southern Illinois
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Southern Illinois Luxury Hotels
Our top choices for Southern Illinois luxury hotels
8.4 out of 10, Very good, (868 reviews)
- Plush beds and serene pool define luxury at Mt. Vernon retreat where spa awaits after exploration.
The price is S$186
includes taxes & fees
25 Jul - 26 Jul
9.4 out of 10, Exceptional, (482 reviews)
- Indulge in a luxurious retreat featuring a full-service spa, indoor pool, and casino gaming in the heart of Carterville.
The price is S$176
includes taxes & fees
21 Jul - 22 Jul
8.2 out of 10, Very good, (1,004 reviews)
- Upscale St. Louis hotel offers steakhouse, indoor pool, and 24-hour fitness centre.
The price is S$148
includes taxes & fees
20 Aug - 21 Aug
10.0 out of 10, Exceptional, (12 reviews)
The price is S$148
includes taxes & fees
22 Jul - 23 Jul
9.4 out of 10, Exceptional, (1,002 reviews)
- Lavish riverside luxury awaits at the Four Seasons St. Louis with spa indulgences and poolside bliss.
The price is S$566
includes taxes & fees
22 Jul - 23 Jul
9.2 out of 10, Wonderful, (575 reviews)
- Ritz-Carlton elegance defines this St. Louis retreat with indulgent spa services and dining excellence.
The price is S$752
includes taxes & fees
26 Jul - 27 Jul
The price is S$270
includes taxes & fees
19 Aug - 20 Aug
9.0 out of 10, Wonderful, (1,998 reviews)
- Boutique retreat blends urban charm with luxury, from rooftop views to Egyptian cotton and rainfall showers.
The price is S$231
includes taxes & fees
2 Aug - 3 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southern Illinois Hotel Reviews
Comfort Suites Mount Vernon
10/10 Excellent
Explore a world of travel with Expedia
- 3 Star Hotels in Odin
- 4 Star Hotels in Sims
- 5 Star Hotels in Sims
- Albion Hotels
- Altamont Hotels
- Ava Hotels
- Baldwin Hotels
- Carbondale Hotels
- Carlyle Hotels
- Carterville Hotels
- Centralia Hotels
- Chester Hotels
- Fairfield Hotels
- Farina Hotels
- Flora Hotels
- Grayville Hotels
- Hotels near Grayville Memorial Park
- Greenville Hotels
- Herald Hotels
- Herod Hotels
- Herrin Hotels
- Highland Hotels
- Ina Hotels
- Kinmundy Hotels
- Lebanon Hotels
- Makanda Hotels
- Gay friendly Hotels in Marion
- Marissa Hotels
- Mount Vernon Hotels
- Hotels near Mount Vernon Outland
- Muddy Hotels
- Mulberry Grove Hotels
- Murphysboro Hotels
- Nashville Hotels
- New Athens Hotels
- Noble Hotels
- Odin Hotels
- Hotels with Swimming Pools in Olney
- Pinckneyville Hotels
- Pocahontas Hotels
- Pulleys Mill Hotels
- Saint Elmo Hotels
- Salem Hotels
- Sims Hotels
- Hotels with Restaurants in Southeast Illinois
- Hotels with connecting rooms in Southwest Illinois
- Motels in Southwest Illinois
- Sparta Hotels
- St. Jacob Hotels
- Steeleville Hotels
- Guest Houses in Tunnel Hill
- Walsh Hotels
- Waltonville Hotels
- Wertenberg Hotels
- Flights to Marion
- Flights to Sparta
- Flights to West Frankfort
- Flights from Chicago (MDW) to Carbondale (MDH)
- Flights from Masirah (MSH) to Marion (MWA)
- Flights from St. Petersburg (PIE) to Carbondale (MDH)
- Flights from Pittsburgh (PIT) to Carbondale (MDH)
- Flights from Singapore (SIN) to Marion (MWA)