Photo by Piccolo Lorenzo

Hotels in Santa Lucia

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
18 Dec - 19 Dec
Tomorrow
19 Dec - 20 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Lucia hotels

Terrace/patio
Caportigia Boutique Hotel

Caportigia Boutique Hotel

Caportigia Boutique Hotel
5.0 star property
Santa Lucia
9.4 out of 10, Exceptional, (257)
"Fine quality hotel with exceptional service. "
United States
Peter
The price is S$180
includes taxes & fees
21 Dec - 22 Dec
Caportigia Boutique Hotel
Aerial view
Grande Albergo Alfeo

Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (651)
"The room was nice the location convenient. No view to speak of but centrally located"
Canada
Eric
Grande Albergo Alfeo
Premium bedding, minibar, desk, soundproofing
B&B Nike

B&B Nike

B&B Nike
Santa Lucia
8.8 out of 10, Excellent, (75)
"Clean, good location. "
United States
Salvatore
B&B Nike
Coffee/tea maker, electric kettle
Nostos rooms & Apartments

Nostos rooms & Apartments

Nostos rooms & Apartments
3.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (273)
"On a main thoroughfare close to Isola di Ortigia. Friendly management and helpful to me."
United States
John
The price is S$92
includes taxes & fees
5 Jan - 6 Jan, 2026
Nostos rooms & Apartments
In-room safe, soundproofing, iron/ironing board, free WiFi
Isonzo Suites

Isonzo Suites

Isonzo Suites
Santa Lucia
8.4 out of 10, Very good, (5)
"."
Italy
Gianluca
The price is S$150
includes taxes & fees
14 Jan - 15 Jan, 2026
Isonzo Suites
View from room
Hotel Mediterraneo

Hotel Mediterraneo

Hotel Mediterraneo
3.0 star property
Santa Lucia
7.8 out of 10, Good, (122)
"Very friendly and helpful staff."
United States
David
Hotel Mediterraneo
Full-sized fridge, oven, stovetop, cookware/dishes/utensils
Gymnasium

Gymnasium

Gymnasium
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (40)
"Nice kitchen area, centrally located."
United States
Richard
Gymnasium
Terrace/patio
Piccolo Hotel Casa Mia

Piccolo Hotel Casa Mia

Piccolo Hotel Casa Mia
3.0 star property
Santa Lucia
8.6 out of 10, Excellent, (373)
"The staff is extremely nice and friendly and you feel welcome. "
Canada
Florentina
Piccolo Hotel Casa Mia
Property entrance
Giuggiulena Villa

Giuggiulena Villa

Giuggiulena Villa
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (126)
"Fantastic stay. Made to feel very welcome and what a lovely relaxing place to stay. Evening meal was exceptional. "
United States
Paul
The price is S$322
includes taxes & fees
4 Jan - 5 Jan, 2026
Giuggiulena Villa
View from room
Calafatari B&B

Calafatari B&B

Calafatari B&B
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (11)
"We had a lovely stay. Anna was very welcoming. We had a lovely large clean room and a nice modern bathroom. She went all out for breakfast. "
United States
Carl and Lina
Calafatari B&B
Premium bedding, desk, cots/infant beds, rollaway beds
B&B Siracusa

B&B Siracusa

B&B Siracusa
Santa Lucia
9.0 out of 10, Wonderful, (59)
"Good location, very modern clean accommodation."
Canada
Malcolm
The price is S$106
includes taxes & fees
27 Dec - 28 Dec
B&B Siracusa
Minibar, in-room safe, desk, soundproofing
Lakkios

Lakkios

Lakkios
3.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (62)
"Nice, central, clean, easy to park, quiet during the night, staff was welcoming, nice breakfast with view - excellent choice!"
Norway
Jon-Kåre
Lakkios
Exterior
AmaCasa Siracusa

AmaCasa Siracusa

AmaCasa Siracusa
Santa Lucia
10.0 out of 10, Exceptional, (1)
"Siamo stati molto bene, la struttura internamente è abbastanza ammodernata e l'accesso è stato"
Italy
Alessandro
The price is S$138
includes taxes & fees
19 Dec - 20 Dec
AmaCasa Siracusa
Soundproofing, free WiFi
Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri
4.0 star property
Santa Lucia
8.8 out of 10, Excellent, (39)
"The location of this hotel is ideal! Directly between the train station and Ortigia. Easy walking to many different restaurants. We very much enjoyed our short stay here and the daily activities hosted by the Hotel. My only iffy thing was the tiles in the bathroom (the shower specifically) seemed a bit older and maybe not as cleanly as it could be, but all in all the room was quite nice. "
Canada
Lindsay
The price is S$162
includes taxes & fees
13 Jan - 14 Jan, 2026
Hotel Palazzo Cavalieri
Water view
Re Dionisio Luxury Suites

Re Dionisio Luxury Suites

Re Dionisio Luxury Suites
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (57)
"Spacious room, dated but comfortable."
United States
Kenneth
The price is S$378
includes taxes & fees
28 Dec - 29 Dec
Re Dionisio Luxury Suites
Desk, laptop workspace, free WiFi
Agorà

Agorà

Agorà
Santa Lucia
10.0 out of 10, Exceptional, (1)
"Carlo was great. He wanted to help in any way. The room was excellent except for Friday night music and traffic. You want to party it is near there. Would stay there again. Walkable to most places. Good restaurants near by."
United States
Bryce
The price is S$118
includes taxes & fees
19 Dec - 20 Dec
Agorà
Memory-foam beds, in-room safe, individually furnished, desk
Fortaleza Charme House

Fortaleza Charme House

Fortaleza Charme House
Santa Lucia
10.0 out of 10, Exceptional, (27)
"Great central location."
United States
Craig
The price is S$216
includes taxes & fees
19 Dec - 20 Dec
Fortaleza Charme House
Terrace/patio
Populus

Populus

Populus
1.0 star property
Santa Lucia
7.8 out of 10, Good, (74)
"Just stay somewhere else, plain and simple."
United States
Thomas
The price is S$117
includes taxes & fees
18 Jan - 19 Jan, 2026
Populus
Egyptian cotton sheets, premium bedding, down duvets, blackout curtains
Fortuna Guest House

Fortuna Guest House

Fortuna Guest House
1.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (16)
"It was easy to register, clean and a good location. Not to mention the free croissant in the morning!"
Australia
Barbara
The price is S$170
includes taxes & fees
5 Jan - 6 Jan, 2026
Fortuna Guest House
Exterior
Hotel dei Coloniali

Hotel dei Coloniali

Hotel dei Coloniali
3.0 star property
Santa Lucia
7.4 out of 10, Good, (166)
"Convenient location for Syracuse town, but in a scruffy area and the whole property is looking tired. Breakfast was adequate. The owner was charming and happy to help."
United Kingdom
Rod
Hotel dei Coloniali
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Lucia

Find the best Santa Lucia areas for the activities you enjoy most.

Ortigia

Ortigia is popular for its seaside views, and if you're looking for more to see and do, you might think about a trip to Cathedral of Syracuse or Piazza del Duomo.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider stopping by Ionian Sea while you're exploring the neighbourhood.

Neapolis

While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

Grottasanta

Grottasanta is noteworthy for its historical sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

Top Santa Lucia Hotel Reviews

Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

10/10 Excellent
"Overall, an excellent hotel in a great location. Beautiful building, comfortable bed, wonderful breakfast in the morning. Really can’t complain about anything. "
Charlie 4-night trip
Posted 11 days ago
Algila' Ortigia Charme Hotel

Frequently asked questions

What is Santa Lucia like?
Santa Lucia is a neighbourhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Make sure that you visit Porto Piccolo and Ionian Sea while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Lucia?
Based on Expedia customer reviews, Fortaleza Charme House is the highest ranked property in Santa Lucia. This inn offers a beach bar and free WiFi. Other top choices in the neighbourhood include Giuggiulena Villa and Caportigia Boutique Hotel.
How many hotels will I find in Santa Lucia?
Expedia has 292 hotels and other accommodation options in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.
If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review the best options available in Santa Lucia.
What are the top things to see and do in Santa Lucia?
Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops worth a visit in the neighbourhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.

Explore a world of travel with Expedia