Top 10 Santa Lucia Hotels of 2026

The Sanctuary of the Madonna delle Lacrime was erected in memory of the miraculous lacrimation of the effigy depicting the Immaculate Heart of Mary, placed to the bedside of the spouses Lannuso at their humble home in Via degli Orti in Syracuse, in 1953.

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Compare popular hotels in Santa Lucia

Property	Property class	Guest rating
Giuggiulena Villa	3.0 star property	10.0 Exceptional 126 reviews	View
Caportigia Boutique Hotel	5.0 star property	9.4 Exceptional 268 reviews	View
Nostos rooms & Apartments	3.0 star property	9.0 Wonderful 275 reviews	View
Lakkios	3.0 star property	9.0 Wonderful 64 reviews	View
Gymnasium	3.0 star property	8.8 Excellent 40 reviews	View

Where to stay in Santa Lucia

Find the best Santa Lucia areas for the activities you enjoy most.

Ortigia

Ortigia is popular for its seaside views, and if you're looking for more to see and do, you might think about a trip to Cathedral of Syracuse or Piazza del Duomo.

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The Roman amphitheatre of Syracuse is one of the best preserved structures in the city of Syracuse, Sicily, from the early Imperial period.

Between the arch and the amphitheatre, there was a monumental fountain, fed by a large cistern which has not yet been identified. A separate cistern provided water to the amphitheatre itself - it is preserved under the nearby church of San Nicola.

Neapolis

While visiting Neapolis, you might make a stop by sights like Archaeological Park of Neapolis and Greek Theatre of Syracuse.

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Grotta degli innamorati - Kayak a Siracusa - Santa Panagia

Grottasanta

Grottasanta is noteworthy for its historical sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

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Syracuse, panoramic phot of the Roman Amphitheatre at Syracuse (Siracusa), UNESCO World Heritage Site, Sicily, Italy, Europe

Tiche

Gardens and restaurants are notable features of Tiche. You might consider stopping by Ionian Sea while you're exploring the neighbourhood.

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Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

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Top Santa Lucia Hotel Reviews

Maniace Boutique Hotel Ortigia UNA Esperienze

10/10 Excellent

"My husband and I had an amazing time. The location was ideal. Very close to shopping and restaurants but very quiet. Everyone there was so nice and helpful and the breakfast was perfect for a day of roaming around. We will stay here every time we visit Ortigia"

Grand Hotel Ortigia Siracusa

6/10 Okay

"Superb staff, Emanuel at front desk went above and beyond printing out maps and providing suggestions for day trips. Hotel and rooms are very dated and lack a cohesive look. Bathroom smelled of sewage and the entire hotel had the smell of grandma’s awful perfume. Rooms are small, location is superb and right on the water. Amazing views from the top floor restaurant. Wait staff fantastic and very attentive."

Hotel Palazzo Cavalieri

10/10 Excellent

"Staff was very friendly and helpful. Loved that the front desk was open 24/7 and the location and walk ability was perfect. Room was clean and spacious. The bathroom could use some updating but all worked well and we enjoyed the provided shampoos, soaps, lotions, etc. Very impressed by the included breakfast each morning. Lots of options and all was fresh and tasty. "

Frequently asked questions

What is Santa Lucia like?

Santa Lucia is a neighbourhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Make sure that you visit Porto Piccolo and Ionian Sea while you're in the neighbourhood.

Where is the best hotel for a stay in Santa Lucia?

Based on Expedia customer reviews, Lakkios is the highest ranked property in Santa Lucia. This B&B offers a marina and a bar. Other top choices in the neighbourhood include La casa di Aneupe and Grande Albergo Alfeo.

How many hotels will I find in Santa Lucia?

Expedia has 301 hotels and other accommodation options in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.

If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?

Yes! You'll find that most hotel room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review the best options available in Santa Lucia.

What are the top things to see and do in Santa Lucia?

Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops worth a visit in the neighbourhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.

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Hotels in Santa Lucia

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Our top choices for Santa Lucia hotels

Calafatari B&B

Caportigia Boutique Hotel

Eos Serenity Suites

Fortaleza Charme House

Eos Sea View Apartment

Nostos rooms & Apartments

AmaCasa Siracusa

San Nicola Rooms Siracusa

Agorà

Melody rooms

Casa Miranda Boutique

Hotel Palazzo Cavalieri

B&B Siracusa

B&B Nike

Lakkios

Giuggiulena Villa

Re Dionisio Luxury Suites

Le Camere Luxsury Rooms

Grande Albergo Alfeo

Hotel Le Muse

Compare popular hotels in Santa Lucia

Where to stay in Santa Lucia

Ortigia

Neapolis

Grottasanta

Tiche

Acradina

Top Santa Lucia Hotel Reviews

Maniace Boutique Hotel Ortigia UNA Esperienze

Frequently asked questions

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