Hotels in Uptown
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Uptown hotels
The Principal Hotel
The Principal Hotel30.7 km from Uptown
9.6 out of 10, Exceptional, (307 reviews)
"Great hotel and nice staff!"
Michelle
The price is S$149
includes taxes & fees
22 Jun - 23 Jun
Seasons Inn & Suites Highland
Seasons Inn & Suites Highland28.5 km from Uptown
8.0 out of 10, Very good, (663 reviews)
"The staff is very friendly and accommodating they took care of us very well. "
Philip
The price is S$143
includes taxes & fees
8 Jul - 9 Jul
Comfort Inn & Suites Saint Louis Lafayette Square
Comfort Inn & Suites Saint Louis Lafayette Square20.9 km from Uptown
8.0 out of 10, Very good, (334 reviews)
"Breakfast was good and the motel is located within easy drive to Busch stadium, Union station and Botanical gardens."
Charles
The price is S$159
includes taxes & fees
12 Jul - 13 Jul
River City Casino & Hotel
River City Casino & Hotel28.2 km from Uptown
9.2 out of 10, Wonderful, (1,622 reviews)
"Would stay again in a heartbeat!"
Austin
The price is S$154
includes taxes & fees
29 Jun - 30 Jun
Bel Air Motel
Bel Air Motel23.6 km from Uptown
8.6 out of 10, Excellent, (218 reviews)
"Clean rooms, good stay"
Tai
The price is S$115
includes taxes & fees
22 Jun - 23 Jun
Indian Mound Motel
Indian Mound Motel9.7 km from Uptown
8.0 out of 10, Very good, (198 reviews)
"Friendly staff, not far from the city. I would definitely stay there again!"
Samantha
The price is S$92
includes taxes & fees
22 Jun - 23 Jun
Comfort Inn Alton near I-255
Comfort Inn Alton near I-25529.1 km from Uptown
7.4 out of 10, Good, (566 reviews)
"Beautiful area!!"
Krystyne
The price is S$136
includes taxes & fees
12 Jul - 13 Jul
Super 8 by Wyndham O'Fallon
Super 8 by Wyndham O'Fallon14.1 km from Uptown
6.8 out of 10, (1,013 reviews)
"Bed was comfy and shower was hot. No complaints as I was passing through and just looking for a place to lay my head! Would stay here again!"
Rebekah
The price is S$88
includes taxes & fees
22 Jun - 23 Jun
Country Hearth Inn & Suites Edwardsville St. Louis
Country Hearth Inn & Suites Edwardsville St. Louis13.6 km from Uptown
8.6 out of 10, Excellent, (715 reviews)
"We had a great stay and the breakfast was really good."
Tonya
The price is S$192
includes taxes & fees
1 Jul - 2 Jul
Best Western Troy Hotel
Best Western Troy Hotel10.1 km from Uptown
8.0 out of 10, Very good, (984 reviews)
"We stayed at the best western in May 2026. The room was very clean, staff was helpful, we had all that we needed. The breakfast was also great. We would definitely stay here again."
Joyce
The price is S$114
includes taxes & fees
23 Jun - 24 Jun
Best Western St. Louis Fairview Heights
Best Western St. Louis Fairview Heights7.3 km from Uptown
7.8 out of 10, Good, (12 reviews)
"The room was clean well kept and a good location!!"
Landra
The price is S$114
includes taxes & fees
23 Jun - 24 Jun
Drury Inn & Suites St. Louis Fairview Heights
Drury Inn & Suites St. Louis Fairview Heights7.2 km from Uptown
9.2 out of 10, Wonderful, (1,006 reviews)
"Great place to stay"
Brad
The price is S$149
includes taxes & fees
5 Jul - 6 Jul
Red Lion Inn & Suites Pontoon Beach
Red Lion Inn & Suites Pontoon Beach12.3 km from Uptown
7.8 out of 10, Good, (682 reviews)
"My room was clean with a comfortable bed at a reasonable price. A better option than other similar hotels in the vicinity."
Jim
The price is S$105
includes taxes & fees
22 Jun - 23 Jun
Best Western Plus MidAmerica Hotel
Best Western Plus MidAmerica Hotel19.9 km from Uptown
9.0 out of 10, Wonderful, (1,005 reviews)
"Super close to mid America airport. Great breakfast and they had complimentary chili in the evening."
Scot
The price is S$168
includes taxes & fees
5 Jul - 6 Jul
Quality Inn O'Fallon IL - St. Louis
Quality Inn O'Fallon IL - St. Louis9 km from Uptown
7.4 out of 10, Good, (1,001 reviews)
"Great place to stay"
Tammy
The price is S$104
includes taxes & fees
24 Jun - 25 Jun
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel17.9 km from Uptown
8.8 out of 10, Excellent, (1,305 reviews)
"The staff could not have been nicer even holding our luggage before and after checkout. The beds were super comfy and the rooms extra spacious with a living room area separate from the sleeping space. And just a short walk to Busch Stadium and the arch!!"
Cherie
The price is S$166
includes taxes & fees
5 Jul - 6 Jul
Comfort Inn Edwardsville - St. Louis
Comfort Inn Edwardsville - St. Louis10.9 km from Uptown
8.4 out of 10, Very good, (873 reviews)
"Enjoyed my stay! Hotel was nice and convenient"
Renita M.
The price is S$150
includes taxes & fees
3 Jul - 4 Jul
Super 8 by Wyndham Troy IL/St. Louis Area
Super 8 by Wyndham Troy IL/St. Louis Area9.9 km from Uptown
8.0 out of 10, Very good, (1,003 reviews)
"Good customer service well put together hotel"
Donta
The price is S$97
includes taxes & fees
30 Jun - 1 Jul
Casino Queen Hotel
Casino Queen Hotel16.7 km from Uptown
7.8 out of 10, Good, (2,079 reviews)
"Nice clean place to stay"
Rajean
The price is S$126
includes taxes & fees
22 Jun - 23 Jun
The Knight Center at Washington University
The Knight Center at Washington University27.9 km from Uptown
9.4 out of 10, Exceptional, (581 reviews)
"Great location, restaurant was good too. Staff was nice."
RICHOO Bijoo
The price is S$181
includes taxes & fees
1 Jul - 2 Jul
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Uptown
Find the best Uptown areas for the activities you enjoy most.
Eastport
While visiting Eastport, you might make a stop by sights like Gateway Conference Center and Splash City Family Waterpark.
Mulberry Hills
Though Mulberry Hills may not have many top sights, you can venture to the surrounding area to see attractions like World's Largest Catsup Bottle and Gateway Conference Center.
Historic Downtown Collinsville
Though Historic Downtown Collinsville may not have many top sights, you can venture to the surrounding area to see attractions like World's Largest Catsup Bottle and Gateway Conference Center.
Top Uptown Hotel Reviews
Pear Tree Inn St. Louis Near Union Station
10/10 Excellent
