S$251 Cheap Flights from Des Moines to San Diego

View S$251 flight on Thu, 18 Dec, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to San Diego Intl. Airport (SAN)

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Cheap Flights from Des Moines to San Diego (DSM-SAN)

Prices were available within the past 7 days and start at S$251 for one-way flights and S$450 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Thu, 18 Dec - Thu, 25 Dec
DSM
Des Moines
SAN
San Diego
S$450 Return, found 5 hours ago
S$450
Return
found 5 hours ago
Select Delta flight, departing Thu, 18 Dec from Des Moines to San Diego, returning Thu, 25 Dec, priced at S$450 found 5 hours ago
United
Thu, 18 Dec - Thu, 25 Dec
DSM
Des Moines
SAN
San Diego
S$501 Return, found 5 hours ago
S$501
Return
found 5 hours ago
Select United flight, departing Thu, 18 Dec from Des Moines to San Diego, returning Thu, 25 Dec, priced at S$501 found 5 hours ago
Delta
Thu, 18 Dec - Thu, 25 Dec
DSM
Des Moines
SAN
San Diego
S$502 Return, found 5 hours ago
S$502
Return
found 5 hours ago
Select Delta flight, departing Thu, 18 Dec from Des Moines to San Diego, returning Thu, 25 Dec, priced at S$502 found 5 hours ago
Delta
Thu, 18 Dec - Thu, 25 Dec
DSM
Des Moines
SAN
San Diego
S$529 Return, found 5 hours ago
S$529
Return
found 5 hours ago
Select Delta flight, departing Thu, 18 Dec from Des Moines to San Diego, returning Thu, 25 Dec, priced at S$529 found 5 hours ago
Delta
Thu, 18 Dec - Thu, 25 Dec
DSM
Des Moines
SAN
San Diego
S$537 Return, found 5 hours ago
S$537
Return
found 5 hours ago
Select Delta flight, departing Thu, 18 Dec from Des Moines to San Diego, returning Thu, 25 Dec, priced at S$537 found 5 hours ago
Delta
Thu, 18 Dec - Thu, 25 Dec
DSM
Des Moines
SAN
San Diego
S$538 Return, found 5 hours ago
S$538
Return
found 5 hours ago
Select Delta flight, departing Thu, 18 Dec from Des Moines to San Diego, returning Thu, 25 Dec, priced at S$538 found 5 hours ago
American Airlines
Thu, 18 Dec - Thu, 25 Dec
DSM
Des Moines
SAN
San Diego
S$542 Return, found 5 hours ago
S$542
Return
found 5 hours ago
Select American Airlines flight, departing Thu, 18 Dec from Des Moines to San Diego, returning Thu, 25 Dec, priced at S$542 found 5 hours ago
American Airlines
Thu, 18 Dec - Thu, 25 Dec
DSM
Des Moines
SAN
San Diego
S$554 Return, found 5 hours ago
S$554
Return
found 5 hours ago
Select American Airlines flight, departing Thu, 18 Dec from Des Moines to San Diego, returning Thu, 25 Dec, priced at S$554 found 5 hours ago
United
Thu, 18 Dec - Thu, 25 Dec
DSM
Des Moines
SAN
San Diego
S$554 Return, found 5 hours ago
S$554
Return
found 5 hours ago
Select United flight, departing Thu, 18 Dec from Des Moines to San Diego, returning Thu, 25 Dec, priced at S$554 found 5 hours ago
United
Thu, 18 Dec - Thu, 25 Dec
DSM
Des Moines
SAN
San Diego
S$581 Return, found 5 hours ago
S$581
Return
found 5 hours ago
Select United flight, departing Thu, 18 Dec from Des Moines to San Diego, returning Thu, 25 Dec, priced at S$581 found 5 hours ago

Find the cheapest month to fly from Des Moines (DSM) to San Diego (SAN)

November is typically the cheapest month to fly

From S$193 - S$735 per traveller.
Des Moines to San Diego route information
Origin airport
Des Moines Intl.
Destination airport
San Diego Intl.
Airlines serving
American Airlines, Delta, United
Return price
S$449
Distance
2282 km

Perfect flights from Des Moines to San Diego

Your Journey from Des Moines to San Diego

Start your unforgettable journey with Expedia. Our broad selection of flights from Des Moines to San Diego caters to every travel need. Whether you're yearning for a romantic escape, a solo adventure, or a cultural immersion, we've got you covered.
 

Choosing Your Ideal Flight

With Expedia, you have access to a wide range of airlines, including Delta, American Airlines, United. Our selection of flights from Des Moines Intl. to San Diego Intl. caters to every traveler's requirements, ensuring your journey aligns with your schedule. With options from 20 airlines, you're bound to find the perfect flight.
 

Maximizing Value with Des Moines to San Diego Flights

Experience the joy of finding cheap flights from Des Moines Intl. to San Diego Intl. that fit your budget. Keep an eye out for our special deals and discounts, and check our flexible one-way fares from S$251 and roundtrip prices from S$450*.
 

Pre-Flight Essentials

Ensure a smooth journey from Des Moines to San Diego with Expedia. From information about check-in times and in-flight amenities to guidance on baggage policies, we provide all the essentials to prepare you for your flight.
 

Experience the Vibrant San Diego

Picture yourself stepping off the plane in San Diego and immersing yourself in the unique atmosphere of . From local markets to cultural festivals, each city offers its distinct charm. Make the most of your trip by exploring local attractions and indulging in the local cuisine. With Expedia, explore all this and more, tailored to your budget.
 

Added Convenience on Your Des Moines to San Diego Flight

Traveling with Expedia is more than just a flight. We offer details about in-flight amenities, baggage policies, and more to ensure a smooth and hassle-free journey. Choose from our variety of airlines and embark on a memorable journey from Des Moines to San Diego.
 

Beyond the Flight – Exploring San Diego

With Expedia, your adventure extends beyond the flight. Explore San Diego at your own pace by renting a car or booking a hotel. Discover hidden gems off the beaten path and create unforgettable memories.
 

Book Your Flight from Des Moines to San Diego with Confidence

Planning your next great adventure is a breeze with Expedia. Our user-friendly platform, unbeatable prices, and round-the-clock customer support make your travel experience seamless and stress-free. Embark on your journey from Des Moines to San Diego with confidence. Book your travel arrangements with Expedia today.
 
*Note: Prices may vary based on availability and are subject to change.

Frequently asked questions

How much is a flight from DSM to SAN?
Within the past 7 days on Expedia, for flights departing within the next year, the lowest price listed for a round-trip journey between Des Moines Intl. Airport (DSM) and San Diego Intl. Airport (SAN) was S$450. Fares this cheap don't last long, so make sure you book yours ASAP. Prices and availability are subject to change. Additional terms apply.
Do I need to pay a cancellation fee if I cancel my flight from Des Moines Intl. Airport to San Diego Airport?
This can vary from airline to airline, as each one has its own set of terms and conditions. Visit the Customer Service Portal, where you'll find simple instructions on how to cancel online.
How do I find cheap flights from Des Moines Intl. Airport to San Diego Intl. Airport (SAN) that have flexible change policies?
Many airlines offer the option to reschedule your flight without a change fee. All you pay is the difference between the original flight and the new flight. When you're searching for Des Moines Intl. Airport (DSM) to San Diego Intl. Airport (SAN) flights, you'll see a "no change fees" filter for you to select.
How far is the flight from DSM to San Diego Airport?
You'll be cruising at altitude for a while, as the flight distance from Des Moines to San Diego is 2,300 kilometres. Put together a playlist of your favourite songs before you leave home to keep yourself entertained during your journey.
Which airlines fly direct from Des Moines Intl. Airport (DSM) to San Diego Airport?
Operating 8 flights each month, Allegiant Air (G4) is a top choice when flying directly from DSM to San Diego Airport.
Are DSM to SAN flight tickets cheaper when they're purchased at the last minute?
Booking your trip from Des Moines Intl. Airport to San Diego Airport at the last minute could be your ticket to a great deal. However, it might cost you a whole lot more! If you'd prefer not to take the risk, book well ahead of your departure date. In fact, Expedia has some of the best bargains as far ahead as 12 months in advance. If your preferred air carrier hasn't released tickets yet, check back frequently as deals are updated all the time on Expedia.

Explore a world of travel with Expedia

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