There are several airlines that operate frequent flights from Detroit (DTW) to Istanbul (IST) including

• Delta Air Lines with 100 flights a week
• KLM with 45 flights a week
• Air France with 35 flights a week
• United Airlines with 33 flights a week
• American Airlines with 15 flights a week

The earliest flight leaves Detroit Metropolitan Wayne County Airport at 13:55 and arrives at Ataturk Intl. Airport at 09:25. The last flight of the day departs Detroit at 23:14 and arrives at Istanbul at 23:15.

The flight distance from Detroit to Istanbul is about 9036 km, the shortest flight is 11 hours 20 minutes with WestJet.

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