There are several airlines that operate frequent flights from Sioux Falls (FSD) to Singapore (SIN) including

• United Airlines with 9 flights a week
• American Airlines with 1 flights a week

The earliest flight leaves Sioux Falls Regional Airport at 07:50 and arrives at Changi Airport at 00:15. The last flight of the day departs Sioux Falls at 11:15 and arrives at Singapore at 01:40.

The flight distance from Sioux Falls to Singapore is about 15876 km, the shortest flight is 00 hours with United Airlines."

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